FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003804790> ?p ?o ?g. }

• W2003804790 abstract "Agonist treatment causes desensitization of many G protein-coupled receptor systems. Recent advances have delineated changes in receptors in the desensitization response; however, the role of G proteins remains unclear. We investigated the role of phosphorylation of Galpha q/11 proteins in agonist-induced desensitization of serotonin 2A (5-HT2A) receptors. In an embryonic rat cortical cell line (A1A1v), 24-h treatment with 100 nM (-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI), a 5-HT(2A/2C) receptor agonist, decreased DOI-stimulated inositol phosphate accumulation and increased the phosphorylation of Galpha q/11 proteins, as demonstrated by immunoprecipitation of Galpha q/11 and both incorporation of 32P phosphate and labeling with a S/T/Y phosphorylation-dependent antibody. Treatment with DOI for 30 min induced desensitization but did not increase phosphorylation of Galpha q/11 proteins, suggesting that different mechanisms are involved in desensitization after short- and long-term treatments. Mutation of S154A in a protein kinase C (PKC) and calcium/calmodulin dependent kinase (CaMK) consensus site in Galpha11 significantly reduced DOI-stimulated phosphorylation of Galpha11 and DOI-induced desensitization of 5-HT2A receptor signaling. Inhibition of PKC and CaMK attenuated phosphorylation of Galpha q/11 proteins and DOI-induced desensitization of 5-HT2A receptors. Expression of Galpha11 S154D, a phosphorylation mimic, reduced DOI-stimulated inositol phosphate accumulation. DOI treatment for 24 h also produced heterologous desensitization, as indicated by decreased bradykinin-stimulated inositol phosphate accumulation. These data suggest that phosphorylation of Galpha11 protein by PKC and CaMK contributes to agonist-induced homologous desensitization of 5-HT2A receptor signaling as well as heterologous desensitization. The phosphorylation of Galpha protein represents a novel mechanism involved in regulation of receptor signaling and agonist-induced desensitization of G protein-coupled receptors." @default.
• W2003804790 created "2016-06-24" @default.
• W2003804790 creator A5054146755 @default.
• W2003804790 creator A5069178407 @default.
• W2003804790 creator A5082211612 @default.
• W2003804790 date "2006-10-20" @default.
• W2003804790 modified "2023-09-23" @default.
• W2003804790 title "Phosphorylation of Gα11Protein Contributes to Agonist-Induced Desensitization of 5-HT2AReceptor Signaling" @default.
• W2003804790 cites W1530078108 @default.
• W2003804790 cites W1577717052 @default.
• W2003804790 cites W1983653588 @default.
• W2003804790 cites W1998596192 @default.
• W2003804790 cites W2010364329 @default.
• W2003804790 cites W2018680292 @default.
• W2003804790 cites W2021282200 @default.
• W2003804790 cites W2026107282 @default.
• W2003804790 cites W2029402031 @default.
• W2003804790 cites W2032707530 @default.
• W2003804790 cites W2034419085 @default.
• W2003804790 cites W2036507117 @default.
• W2003804790 cites W2039541786 @default.
• W2003804790 cites W2041181082 @default.
• W2003804790 cites W2059121005 @default.
• W2003804790 cites W2066228306 @default.
• W2003804790 cites W2077222459 @default.
• W2003804790 cites W2087295746 @default.
• W2003804790 cites W2087773298 @default.
• W2003804790 cites W2100175023 @default.
• W2003804790 cites W2106627591 @default.
• W2003804790 cites W2121499374 @default.
• W2003804790 cites W2148606192 @default.
• W2003804790 cites W2166918203 @default.
• W2003804790 cites W2185537993 @default.
• W2003804790 doi "https://doi.org/10.1124/mol.106.028241" @default.
• W2003804790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17056873" @default.
• W2003804790 hasPublicationYear "2006" @default.
• W2003804790 type Work @default.
• W2003804790 sameAs 2003804790 @default.
• W2003804790 citedByCount "21" @default.
• W2003804790 countsByYear W20038047902012 @default.
• W2003804790 countsByYear W20038047902013 @default.
• W2003804790 countsByYear W20038047902014 @default.
• W2003804790 countsByYear W20038047902015 @default.
• W2003804790 countsByYear W20038047902016 @default.
• W2003804790 countsByYear W20038047902017 @default.
• W2003804790 countsByYear W20038047902018 @default.
• W2003804790 countsByYear W20038047902020 @default.
• W2003804790 crossrefType "journal-article" @default.
• W2003804790 hasAuthorship W2003804790A5054146755 @default.
• W2003804790 hasAuthorship W2003804790A5069178407 @default.
• W2003804790 hasAuthorship W2003804790A5082211612 @default.
• W2003804790 hasConcept C11960822 @default.
• W2003804790 hasConcept C134018914 @default.
• W2003804790 hasConcept C170493617 @default.
• W2003804790 hasConcept C185592680 @default.
• W2003804790 hasConcept C195794163 @default.
• W2003804790 hasConcept C2777427919 @default.
• W2003804790 hasConcept C2778618036 @default.
• W2003804790 hasConcept C2778938600 @default.
• W2003804790 hasConcept C2779779143 @default.
• W2003804790 hasConcept C55493867 @default.
• W2003804790 hasConcept C62478195 @default.
• W2003804790 hasConcept C66135807 @default.
• W2003804790 hasConcept C80631254 @default.
• W2003804790 hasConcept C86803240 @default.
• W2003804790 hasConcept C87325107 @default.
• W2003804790 hasConcept C92759361 @default.
• W2003804790 hasConcept C95444343 @default.
• W2003804790 hasConcept C97029542 @default.
• W2003804790 hasConceptScore W2003804790C11960822 @default.
• W2003804790 hasConceptScore W2003804790C134018914 @default.
• W2003804790 hasConceptScore W2003804790C170493617 @default.
• W2003804790 hasConceptScore W2003804790C185592680 @default.
• W2003804790 hasConceptScore W2003804790C195794163 @default.
• W2003804790 hasConceptScore W2003804790C2777427919 @default.
• W2003804790 hasConceptScore W2003804790C2778618036 @default.
• W2003804790 hasConceptScore W2003804790C2778938600 @default.
• W2003804790 hasConceptScore W2003804790C2779779143 @default.
• W2003804790 hasConceptScore W2003804790C55493867 @default.
• W2003804790 hasConceptScore W2003804790C62478195 @default.
• W2003804790 hasConceptScore W2003804790C66135807 @default.
• W2003804790 hasConceptScore W2003804790C80631254 @default.
• W2003804790 hasConceptScore W2003804790C86803240 @default.
• W2003804790 hasConceptScore W2003804790C87325107 @default.
• W2003804790 hasConceptScore W2003804790C92759361 @default.
• W2003804790 hasConceptScore W2003804790C95444343 @default.
• W2003804790 hasConceptScore W2003804790C97029542 @default.
• W2003804790 hasLocation W20038047901 @default.
• W2003804790 hasLocation W20038047902 @default.
• W2003804790 hasOpenAccess W2003804790 @default.
• W2003804790 hasPrimaryLocation W20038047901 @default.
• W2003804790 hasRelatedWork W1975333746 @default.
• W2003804790 hasRelatedWork W1997721198 @default.
• W2003804790 hasRelatedWork W2003265762 @default.
• W2003804790 hasRelatedWork W2003804790 @default.
• W2003804790 hasRelatedWork W2030579890 @default.
• W2003804790 hasRelatedWork W2051484048 @default.
• W2003804790 hasRelatedWork W2065091962 @default.
• W2003804790 hasRelatedWork W2079041972 @default.
• W2003804790 hasRelatedWork W2091080704 @default.

• next