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- W2003806342 abstract "Construction of simple models is an integral part of any scientific investigation, yet it almost never makes it even to the college science curriculum. We developed a series of 4 lessons that uses protein dynamics as a platform to introduce modeling to students at the high school and undergraduate levels. These lessons guide students from a textbook picture of a protein as a rigid crystal structure to a more realistic view: proteins are highly dynamic entities in the crowded environment inside the living cells. Methods of statistics and physical chemistry are employed along the way to investigate a flexible version of a protein that can sample various conformations within the folded ensemble and ultimately unfold into a random coil. Simple mechanical and computer models that evolve in their complexity are at the core of this lesson." @default.
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- W2003806342 date "2012-01-01" @default.
- W2003806342 modified "2023-09-26" @default.
- W2003806342 title "A Simple Model of Protein Folding: From Crystal Structure to the Living Cell" @default.
- W2003806342 doi "https://doi.org/10.1016/j.bpj.2011.11.1150" @default.
- W2003806342 hasPublicationYear "2012" @default.
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