Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003806812> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2003806812 abstract "Summary: Felbamate (FBM, Felbatol/Taloxa) has been the object of several trials that are innovative and unique. First, FBM is the first antiepileptic drug (AED) to have been submitted to a controlled efficacy study in patients with the Len‐nox‐Gastaut syndrome (LGS) before being submitted for regulatory approval. Second, FBM was tested in patients discontinued from other AEDs for presurgical monitoring. Third, FBM was the first experimental AED to have been tested in controlled monotherapy trials. Overall, these studies succeeded in demonstrating that FBM is relatively safe and effective against both partial‐onset seizures and the generalized seizures occurring in the LGS. The results of some of these studies could not always be expressed by using the more familiar concept of percent seizure reduction because, for ethical reasons, the efficacy variable had to be defined in terms of time to the n lh seizure or in terms of escape criteria. This may make it more difficult to evaluate just how effective FBM is in comparison with other AEDs. Another reason why the efficacy of FBM cannot yet be fully assessed is that in all the studies the FBM dosage was limited to a maximum of 3,600 mg/day or 45 mg/kg/day. At this dosage, FBM produced no toxicity in the majority of patients, and its full therapeutic effect may have to be re‐evaluated in the future at higher dosages." @default.
- W2003806812 created "2016-06-24" @default.
- W2003806812 creator A5026925261 @default.
- W2003806812 date "1994-10-01" @default.
- W2003806812 modified "2023-10-06" @default.
- W2003806812 title "Felbamate in the Treatment of Partial-Onset Seizures" @default.
- W2003806812 cites W1992469827 @default.
- W2003806812 cites W1999374340 @default.
- W2003806812 cites W2124279185 @default.
- W2003806812 cites W2139617051 @default.
- W2003806812 cites W2158638175 @default.
- W2003806812 cites W2596598505 @default.
- W2003806812 doi "https://doi.org/10.1111/j.1528-1157.1994.tb05970.x" @default.
- W2003806812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8039474" @default.
- W2003806812 hasPublicationYear "1994" @default.
- W2003806812 type Work @default.
- W2003806812 sameAs 2003806812 @default.
- W2003806812 citedByCount "8" @default.
- W2003806812 countsByYear W20038068122015 @default.
- W2003806812 countsByYear W20038068122020 @default.
- W2003806812 countsByYear W20038068122022 @default.
- W2003806812 crossrefType "journal-article" @default.
- W2003806812 hasAuthorship W2003806812A5026925261 @default.
- W2003806812 hasConcept C118552586 @default.
- W2003806812 hasConcept C126322002 @default.
- W2003806812 hasConcept C162156334 @default.
- W2003806812 hasConcept C2775858608 @default.
- W2003806812 hasConcept C2778186239 @default.
- W2003806812 hasConcept C2779307984 @default.
- W2003806812 hasConcept C2781011581 @default.
- W2003806812 hasConcept C42219234 @default.
- W2003806812 hasConcept C71924100 @default.
- W2003806812 hasConceptScore W2003806812C118552586 @default.
- W2003806812 hasConceptScore W2003806812C126322002 @default.
- W2003806812 hasConceptScore W2003806812C162156334 @default.
- W2003806812 hasConceptScore W2003806812C2775858608 @default.
- W2003806812 hasConceptScore W2003806812C2778186239 @default.
- W2003806812 hasConceptScore W2003806812C2779307984 @default.
- W2003806812 hasConceptScore W2003806812C2781011581 @default.
- W2003806812 hasConceptScore W2003806812C42219234 @default.
- W2003806812 hasConceptScore W2003806812C71924100 @default.
- W2003806812 hasIssue "s5" @default.
- W2003806812 hasLocation W20038068121 @default.
- W2003806812 hasLocation W20038068122 @default.
- W2003806812 hasOpenAccess W2003806812 @default.
- W2003806812 hasPrimaryLocation W20038068121 @default.
- W2003806812 hasRelatedWork W1991564821 @default.
- W2003806812 hasRelatedWork W2003806812 @default.
- W2003806812 hasRelatedWork W2010763797 @default.
- W2003806812 hasRelatedWork W2021551507 @default.
- W2003806812 hasRelatedWork W2058033216 @default.
- W2003806812 hasRelatedWork W2086360825 @default.
- W2003806812 hasRelatedWork W2119240134 @default.
- W2003806812 hasRelatedWork W2133518076 @default.
- W2003806812 hasRelatedWork W2152534985 @default.
- W2003806812 hasRelatedWork W2395771522 @default.
- W2003806812 hasVolume "35" @default.
- W2003806812 isParatext "false" @default.
- W2003806812 isRetracted "false" @default.
- W2003806812 magId "2003806812" @default.
- W2003806812 workType "article" @default.