FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003808139> ?p ?o ?g. }

• W2003808139 endingPage "365" @default.
• W2003808139 startingPage "355" @default.
• W2003808139 abstract "A double-blind randomized comparative phase II study of flutrimazole site-release vaginal cream (1, 2 and 4%) with placebo site-release vaginal cream was undertaken in patients with acute vulvovaginal candidosis. Vaginitis was demonstrated by both positive findings on microscopic examination of vaginal smears and positive culture as well as by the presence of clinical signs and symptoms. The vaginal monodose treatment was inserted in the evening at bedtime using a vaginal applicator and, in addition, all four groups of patients received additional topical external cream for application to the vulva twice-daily for 7 days; the placebo group received a placebo cream and the active therapy groups all received a 2% flutrimazole cream. A total of 133 patients who were seen over a 10-month period were screened and randomized: five patients did not take the allocated medication, and four patients whose menstrual period began shortly after study entry were excluded from the study, leaving 124 patients who were randomly allocated to receive a monodose vaginal 1% cream (regimen A, 28 patients), a monodose vaginal 2% cream (regimen B, 32 patients), a monodose vaginal 4% cream (regimen C, 31 patients) or a monodose vaginal placebo cream (regimen D, 33 patients). At the assessment 9 days after the end of therapy the proportion of patients who were cured was 82% in group A, 87.4% in group B, 83.8% in group C and 63.5% in group D. Three patients (10.7%) in group A, four (12.5%) in group B, one (3.2%) in group C and 12 (36.36%) in group D did not respond to the treatment. One patient (3.5%) in group A, and two patients (6.4%) in group C terminated the treatment prematurely due to intolerance. There was a significant association between Candida glabrata and treatment failure (P < 0.04) and C. glabrata and carrier state (P = 0.01) in vagina (chi 2 test, P = 0.01) and vulvovagina (chi 2 test, P = 0.00001). At the assessment 4 weeks after the end of therapy the proportion of cured patients was 60.6% in group A, 78% in group B, 80.6% in group C and 48.4% in group D. Group D (placebo) versus group B (2%) and group C (4%) showed a significant difference (P = 0.01 and P = 0.007, respectively). Although there were no significant differences in clinical and mycological activity between the three active groups, group B (flutrimazole 2% site-release vaginal cream) was chosen for clinical use due to its tolerance profile. Seven patients (25%) in group A, three (9.3%) in group B, two (6.4%) in group C and five (15.1%) in group D relapsed 4 weeks after the end of therapy; the relapse rate was not significantly associated with positive culture results 9 days after treatment. There was a significant association between C. glabrata and the carrier state (P < 0.01). The overall ineffective treatment (includes failures at control 1, relapses at control 2 and premature terminations) was 39% in group A, 21.7% in group B, 16% in group C and 51.3% in group D. There was a significant difference in the overall ineffective treatment when C and D groups were compared with placebo (P = 0.01 and P = 0.003, respectively)." @default.
• W2003808139 created "2016-06-24" @default.
• W2003808139 creator A5007432383 @default.
• W2003808139 creator A5023054925 @default.
• W2003808139 creator A5030373099 @default.
• W2003808139 creator A5045453819 @default.
• W2003808139 creator A5046392735 @default.
• W2003808139 creator A5065326750 @default.
• W2003808139 creator A5087474415 @default.
• W2003808139 creator A5088754419 @default.
• W2003808139 creator A5089143026 @default.
• W2003808139 date "2000-10-02" @default.
• W2003808139 modified "2023-09-27" @default.
• W2003808139 title "Double-blind randomized dose-finding study in acute vulvovaginal candidosis. Comparison of flutrimazole site-releaseR cream (1, 2 and 4%) with placebo site-releaseR vaginal cream" @default.
• W2003808139 cites W142178609 @default.
• W2003808139 cites W1565412662 @default.
• W2003808139 cites W1868667984 @default.
• W2003808139 cites W1975115559 @default.
• W2003808139 cites W1975170504 @default.
• W2003808139 cites W1985261132 @default.
• W2003808139 cites W1988790508 @default.
• W2003808139 cites W1994897656 @default.
• W2003808139 cites W2004252271 @default.
• W2003808139 cites W2007388866 @default.
• W2003808139 cites W2067090728 @default.
• W2003808139 cites W2090202463 @default.
• W2003808139 cites W2094445263 @default.
• W2003808139 cites W2099245364 @default.
• W2003808139 cites W2122543063 @default.
• W2003808139 cites W2143839871 @default.
• W2003808139 cites W2148869257 @default.
• W2003808139 cites W2161531503 @default.
• W2003808139 cites W4248282437 @default.
• W2003808139 doi "https://doi.org/10.1046/j.1439-0507.2000.00575.x" @default.
• W2003808139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11105539" @default.
• W2003808139 hasPublicationYear "2000" @default.
• W2003808139 type Work @default.
• W2003808139 sameAs 2003808139 @default.
• W2003808139 citedByCount "12" @default.
• W2003808139 countsByYear W20038081392014 @default.
• W2003808139 countsByYear W20038081392015 @default.
• W2003808139 countsByYear W20038081392016 @default.
• W2003808139 countsByYear W20038081392019 @default.
• W2003808139 crossrefType "journal-article" @default.
• W2003808139 hasAuthorship W2003808139A5007432383 @default.
• W2003808139 hasAuthorship W2003808139A5023054925 @default.
• W2003808139 hasAuthorship W2003808139A5030373099 @default.
• W2003808139 hasAuthorship W2003808139A5045453819 @default.
• W2003808139 hasAuthorship W2003808139A5046392735 @default.
• W2003808139 hasAuthorship W2003808139A5065326750 @default.
• W2003808139 hasAuthorship W2003808139A5087474415 @default.
• W2003808139 hasAuthorship W2003808139A5088754419 @default.
• W2003808139 hasAuthorship W2003808139A5089143026 @default.
• W2003808139 hasConcept C121332964 @default.
• W2003808139 hasConcept C126322002 @default.
• W2003808139 hasConcept C1276947 @default.
• W2003808139 hasConcept C141071460 @default.
• W2003808139 hasConcept C142724271 @default.
• W2003808139 hasConcept C168563851 @default.
• W2003808139 hasConcept C204787440 @default.
• W2003808139 hasConcept C27081682 @default.
• W2003808139 hasConcept C2776316342 @default.
• W2003808139 hasConcept C2776393945 @default.
• W2003808139 hasConcept C2776476923 @default.
• W2003808139 hasConcept C2777617518 @default.
• W2003808139 hasConcept C2777700855 @default.
• W2003808139 hasConcept C2777744392 @default.
• W2003808139 hasConcept C2777785397 @default.
• W2003808139 hasConcept C2778537899 @default.
• W2003808139 hasConcept C2781413609 @default.
• W2003808139 hasConcept C29456083 @default.
• W2003808139 hasConcept C71924100 @default.
• W2003808139 hasConceptScore W2003808139C121332964 @default.
• W2003808139 hasConceptScore W2003808139C126322002 @default.
• W2003808139 hasConceptScore W2003808139C1276947 @default.
• W2003808139 hasConceptScore W2003808139C141071460 @default.
• W2003808139 hasConceptScore W2003808139C142724271 @default.
• W2003808139 hasConceptScore W2003808139C168563851 @default.
• W2003808139 hasConceptScore W2003808139C204787440 @default.
• W2003808139 hasConceptScore W2003808139C27081682 @default.
• W2003808139 hasConceptScore W2003808139C2776316342 @default.
• W2003808139 hasConceptScore W2003808139C2776393945 @default.
• W2003808139 hasConceptScore W2003808139C2776476923 @default.
• W2003808139 hasConceptScore W2003808139C2777617518 @default.
• W2003808139 hasConceptScore W2003808139C2777700855 @default.
• W2003808139 hasConceptScore W2003808139C2777744392 @default.
• W2003808139 hasConceptScore W2003808139C2777785397 @default.
• W2003808139 hasConceptScore W2003808139C2778537899 @default.
• W2003808139 hasConceptScore W2003808139C2781413609 @default.
• W2003808139 hasConceptScore W2003808139C29456083 @default.
• W2003808139 hasConceptScore W2003808139C71924100 @default.
• W2003808139 hasIssue "9-10" @default.
• W2003808139 hasLocation W20038081391 @default.
• W2003808139 hasLocation W20038081392 @default.
• W2003808139 hasOpenAccess W2003808139 @default.
• W2003808139 hasPrimaryLocation W20038081391 @default.
• W2003808139 hasRelatedWork W1893941921 @default.
• W2003808139 hasRelatedWork W2003808139 @default.

• next