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- W2003809583 abstract "The long-acting somatostatin (SMS) analog, SMS 201–995 has beneficial effects on APUDomas. In two Zollinger-Ellison syndrome (ZES) patients we assessed basal acid output (BAO) and 24-h pH under SMS and compared them to controls. We also assessed total gastrin, gastrin 17, insulin, glucagon, C-peptide, and SMS by radioimmunoassay. In the benign gastrinoma, an acid-controlling action of SMS was shown, elevating the 24-h pH threshold over the pH range 1.5–5 of 55–10% compared with control. A parallel inhibition of the gastrins >90% was apparent. We found no beneficial effect on gastric acid secretion and on tumor gastrin in the malignant gastrinoma despite a fourfold higher plasma SMS level. Non-tumor-related peptides were suppressed by approximately 50% and in contrast to gastrin they again reached pre-SMS levels before the next dose of the drug. We conclude that SMS is more effective in benign than in malignant gastrinomas, and may be exclusively so." @default.
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- W2003809583 date "1989-06-01" @default.
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- W2003809583 title "Long-Acting Somatostatin Analog Controls Acid and Gastrin Secretion in Benign, Not in Malignant, Zollinger-Ellison Syndrome" @default.
- W2003809583 doi "https://doi.org/10.1097/00004836-198906000-00007" @default.
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