FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003809857> ?p ?o ?g. }

• W2003809857 endingPage "60" @default.
• W2003809857 startingPage "47" @default.
• W2003809857 abstract "In animal models, exposure of the brain, heart, or kidneys to sublethal ischemia induces tolerance for subsequent ischemia. However, the ability of human renal cells to undergo hypoxic preconditioning has not been evaluated. In addition, it is unclear if renal ischemic preconditioning induces resistance at the cellular level, or if preconditioning is a result of altered postischemic hemodynamics or the azotemic environment. In this study, we tested the ability of cultured human proximal tubular epithelial cells (PTEC) to undergo hypoxic preconditioning at the cellular level. Hypoxia was induced by incubating cells in an anaerobic incubator in glucose-free buffer (combined oxygen-glucose deprivation; COGD). Cell injury was assessed by lactate dehydrogenase (LDH) efflux, release of arachidonic acid metabolites, and light microscopy. PTEC preconditioned with 12 h of COGD and a 24-h recovery period had less LDH efflux than control PTEC after subsequent exposure to 20 h of COGD (15.0 ± 2.5% vs. 44.0 ± 3.4%, p < 0.05). Preconditioned PTEC also retained relatively normal morphology and had less release of arachidonic acid metab olites than control PTEC. Because renal ischemia is characterized predominately by tubular injury with relative sparing of the glomerulus, we determined if PTEC are more susceptible to hypoxic injury than glomerular cells. For further comparison, we also assessed the susceptibility to hypoxia of the porcine tubular epithelial cell line LLC-PK1. After exposure to 18 h ofCOGD, LDH efflux from PTEC (25.5 ± 3.3%, mean ± SEM) was lower than from LLCPK1 cells (47.6 ± 4.0%; p < 0.01), but not mesangial cells (22.7 ± 5.0%) or glomerular endothelial cells (38.2 ± 6.2%). In conclusion, we have demonstrated that cultured PTEC are as resistant to hypoxic injury as glomerular cells, and that PTEC attain cytoresistance after hypoxic preconditioning. Characterization of the molecular changes that occur in human PTEC after hypoxic preconditioning may reveal innate survival mechanisms that can be manipulated to promote protection from renal ischemia in patients." @default.
• W2003809857 created "2016-06-24" @default.
• W2003809857 creator A5015229618 @default.
• W2003809857 creator A5059246094 @default.
• W2003809857 date "1997-01-01" @default.
• W2003809857 modified "2023-10-12" @default.
• W2003809857 title "Susceptibility of Human Proximal Tubular Cells to Hypoxia: Effect of Hypoxic Preconditioning and Comparison to Glomerular Cells" @default.
• W2003809857 cites W1922925354 @default.
• W2003809857 cites W1960899122 @default.
• W2003809857 cites W1978221784 @default.
• W2003809857 cites W1984612664 @default.
• W2003809857 cites W1989655755 @default.
• W2003809857 cites W1989779461 @default.
• W2003809857 cites W1996633032 @default.
• W2003809857 cites W1999839467 @default.
• W2003809857 cites W2007330950 @default.
• W2003809857 cites W2010018722 @default.
• W2003809857 cites W2018215233 @default.
• W2003809857 cites W2019117547 @default.
• W2003809857 cites W2021917270 @default.
• W2003809857 cites W2023651646 @default.
• W2003809857 cites W2029578870 @default.
• W2003809857 cites W2034383633 @default.
• W2003809857 cites W2037469233 @default.
• W2003809857 cites W2043155095 @default.
• W2003809857 cites W2046278838 @default.
• W2003809857 cites W2047568877 @default.
• W2003809857 cites W2061741968 @default.
• W2003809857 cites W2063123103 @default.
• W2003809857 cites W2070399370 @default.
• W2003809857 cites W2076203177 @default.
• W2003809857 cites W2076632262 @default.
• W2003809857 cites W2081606516 @default.
• W2003809857 cites W2084599608 @default.
• W2003809857 cites W2089809656 @default.
• W2003809857 cites W2093525170 @default.
• W2003809857 cites W2096035742 @default.
• W2003809857 cites W2101882892 @default.
• W2003809857 cites W2114051360 @default.
• W2003809857 cites W2117398210 @default.
• W2003809857 cites W2123110565 @default.
• W2003809857 cites W2126975410 @default.
• W2003809857 cites W2417763973 @default.
• W2003809857 doi "https://doi.org/10.3109/08860229709026259" @default.
• W2003809857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9044451" @default.
• W2003809857 hasPublicationYear "1997" @default.
• W2003809857 type Work @default.
• W2003809857 sameAs 2003809857 @default.
• W2003809857 citedByCount "44" @default.
• W2003809857 countsByYear W20038098572012 @default.
• W2003809857 countsByYear W20038098572015 @default.
• W2003809857 countsByYear W20038098572018 @default.
• W2003809857 countsByYear W20038098572020 @default.
• W2003809857 countsByYear W20038098572022 @default.
• W2003809857 countsByYear W20038098572023 @default.
• W2003809857 crossrefType "journal-article" @default.
• W2003809857 hasAuthorship W2003809857A5015229618 @default.
• W2003809857 hasAuthorship W2003809857A5059246094 @default.
• W2003809857 hasConcept C126322002 @default.
• W2003809857 hasConcept C134018914 @default.
• W2003809857 hasConcept C178790620 @default.
• W2003809857 hasConcept C181199279 @default.
• W2003809857 hasConcept C185592680 @default.
• W2003809857 hasConcept C2777318727 @default.
• W2003809857 hasConcept C2778078955 @default.
• W2003809857 hasConcept C2780091579 @default.
• W2003809857 hasConcept C540031477 @default.
• W2003809857 hasConcept C541997718 @default.
• W2003809857 hasConcept C55493867 @default.
• W2003809857 hasConcept C71924100 @default.
• W2003809857 hasConcept C7836513 @default.
• W2003809857 hasConcept C86803240 @default.
• W2003809857 hasConcept C98274493 @default.
• W2003809857 hasConceptScore W2003809857C126322002 @default.
• W2003809857 hasConceptScore W2003809857C134018914 @default.
• W2003809857 hasConceptScore W2003809857C178790620 @default.
• W2003809857 hasConceptScore W2003809857C181199279 @default.
• W2003809857 hasConceptScore W2003809857C185592680 @default.
• W2003809857 hasConceptScore W2003809857C2777318727 @default.
• W2003809857 hasConceptScore W2003809857C2778078955 @default.
• W2003809857 hasConceptScore W2003809857C2780091579 @default.
• W2003809857 hasConceptScore W2003809857C540031477 @default.
• W2003809857 hasConceptScore W2003809857C541997718 @default.
• W2003809857 hasConceptScore W2003809857C55493867 @default.
• W2003809857 hasConceptScore W2003809857C71924100 @default.
• W2003809857 hasConceptScore W2003809857C7836513 @default.
• W2003809857 hasConceptScore W2003809857C86803240 @default.
• W2003809857 hasConceptScore W2003809857C98274493 @default.
• W2003809857 hasIssue "1" @default.
• W2003809857 hasLocation W20038098571 @default.
• W2003809857 hasLocation W20038098572 @default.
• W2003809857 hasOpenAccess W2003809857 @default.
• W2003809857 hasPrimaryLocation W20038098571 @default.
• W2003809857 hasRelatedWork W2009454127 @default.
• W2003809857 hasRelatedWork W2032738451 @default.
• W2003809857 hasRelatedWork W2042033030 @default.
• W2003809857 hasRelatedWork W2070511355 @default.
• W2003809857 hasRelatedWork W2082456910 @default.

• next