FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003812977> ?p ?o ?g. }

• W2003812977 endingPage "768" @default.
• W2003812977 startingPage "760" @default.
• W2003812977 abstract "Urinary concentrations of creatine and guanidinoacetic acid divided by creatinine are informative markers for cerebral creatine deficiency syndromes (CDSs). The renal excretion of these substances varies substantially with age and sex, challenging the sensitivity and specificity of postanalytical interpretation.Results from 155 patients with CDS and 12 507 reference individuals were contributed by 5 diagnostic laboratories. They were binned into 104 adjacent age intervals and renormalized with Box-Cox transforms (Ξ). Estimates for central tendency (μ) and dispersion (σ) of Ξ were obtained for each bin. Polynomial regression analysis was used to establish the age dependence of both μ[log(age)] and σ[log(age)]. The regression residuals were then calculated as z-scores = {Ξ - μ[log(age)]}/σ[log(age)]. The process was iterated until all z-scores outside Tukey fences ±3.372 were identified and removed. Continuous percentile charts were then calculated and plotted by retransformation.Statistically significant and biologically relevant subgroups of z-scores were identified. Significantly higher marker values were seen in females than males, necessitating separate reference intervals in both adolescents and adults. Comparison between our reconstructed reference percentiles and current standard age-matched reference intervals highlights an underlying risk of false-positive and false-negative events at certain ages.Disease markers depending strongly on covariates such as age and sex require large numbers of reference individuals to establish peripheral percentiles with sufficient precision. This is feasible only through collaborative data sharing and the use of appropriate statistical methods. Broad application of this approach can be implemented through freely available Web-based software." @default.
• W2003812977 created "2016-06-24" @default.
• W2003812977 creator A5000647338 @default.
• W2003812977 creator A5003908509 @default.
• W2003812977 creator A5011617048 @default.
• W2003812977 creator A5024539929 @default.
• W2003812977 creator A5026927546 @default.
• W2003812977 creator A5035257595 @default.
• W2003812977 creator A5035745178 @default.
• W2003812977 creator A5041317444 @default.
• W2003812977 creator A5044968268 @default.
• W2003812977 creator A5051616038 @default.
• W2003812977 creator A5070458624 @default.
• W2003812977 creator A5079441088 @default.
• W2003812977 creator A5085423423 @default.
• W2003812977 date "2015-05-01" @default.
• W2003812977 modified "2023-10-17" @default.
• W2003812977 title "Continuous Age- and Sex-Adjusted Reference Intervals of Urinary Markers for Cerebral Creatine Deficiency Syndromes: A Novel Approach to the Definition of Reference Intervals" @default.
• W2003812977 cites W1935786512 @default.
• W2003812977 cites W1985893460 @default.
• W2003812977 cites W2007139251 @default.
• W2003812977 cites W2009740675 @default.
• W2003812977 cites W2015465026 @default.
• W2003812977 cites W2021538725 @default.
• W2003812977 cites W2023608174 @default.
• W2003812977 cites W2036569695 @default.
• W2003812977 cites W2039255263 @default.
• W2003812977 cites W2041358155 @default.
• W2003812977 cites W2045347081 @default.
• W2003812977 cites W2062343814 @default.
• W2003812977 cites W2072374346 @default.
• W2003812977 cites W2093832394 @default.
• W2003812977 cites W2101161334 @default.
• W2003812977 cites W2105083626 @default.
• W2003812977 cites W2129691431 @default.
• W2003812977 cites W2132641156 @default.
• W2003812977 cites W2149731191 @default.
• W2003812977 cites W2157114400 @default.
• W2003812977 cites W2171503863 @default.
• W2003812977 cites W2418675761 @default.
• W2003812977 cites W4241996101 @default.
• W2003812977 doi "https://doi.org/10.1373/clinchem.2014.235564" @default.
• W2003812977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25759465" @default.
• W2003812977 hasPublicationYear "2015" @default.
• W2003812977 type Work @default.
• W2003812977 sameAs 2003812977 @default.
• W2003812977 citedByCount "32" @default.
• W2003812977 countsByYear W20038129772016 @default.
• W2003812977 countsByYear W20038129772017 @default.
• W2003812977 countsByYear W20038129772019 @default.
• W2003812977 countsByYear W20038129772020 @default.
• W2003812977 countsByYear W20038129772021 @default.
• W2003812977 countsByYear W20038129772022 @default.
• W2003812977 countsByYear W20038129772023 @default.
• W2003812977 crossrefType "journal-article" @default.
• W2003812977 hasAuthorship W2003812977A5000647338 @default.
• W2003812977 hasAuthorship W2003812977A5003908509 @default.
• W2003812977 hasAuthorship W2003812977A5011617048 @default.
• W2003812977 hasAuthorship W2003812977A5024539929 @default.
• W2003812977 hasAuthorship W2003812977A5026927546 @default.
• W2003812977 hasAuthorship W2003812977A5035257595 @default.
• W2003812977 hasAuthorship W2003812977A5035745178 @default.
• W2003812977 hasAuthorship W2003812977A5041317444 @default.
• W2003812977 hasAuthorship W2003812977A5044968268 @default.
• W2003812977 hasAuthorship W2003812977A5051616038 @default.
• W2003812977 hasAuthorship W2003812977A5070458624 @default.
• W2003812977 hasAuthorship W2003812977A5079441088 @default.
• W2003812977 hasAuthorship W2003812977A5085423423 @default.
• W2003812977 hasBestOaLocation W20038129771 @default.
• W2003812977 hasConcept C105795698 @default.
• W2003812977 hasConcept C107130276 @default.
• W2003812977 hasConcept C122048520 @default.
• W2003812977 hasConcept C126322002 @default.
• W2003812977 hasConcept C2779896295 @default.
• W2003812977 hasConcept C33923547 @default.
• W2003812977 hasConcept C44249647 @default.
• W2003812977 hasConcept C48718317 @default.
• W2003812977 hasConcept C48921125 @default.
• W2003812977 hasConcept C71924100 @default.
• W2003812977 hasConceptScore W2003812977C105795698 @default.
• W2003812977 hasConceptScore W2003812977C107130276 @default.
• W2003812977 hasConceptScore W2003812977C122048520 @default.
• W2003812977 hasConceptScore W2003812977C126322002 @default.
• W2003812977 hasConceptScore W2003812977C2779896295 @default.
• W2003812977 hasConceptScore W2003812977C33923547 @default.
• W2003812977 hasConceptScore W2003812977C44249647 @default.
• W2003812977 hasConceptScore W2003812977C48718317 @default.
• W2003812977 hasConceptScore W2003812977C48921125 @default.
• W2003812977 hasConceptScore W2003812977C71924100 @default.
• W2003812977 hasFunder F4320306143 @default.
• W2003812977 hasIssue "5" @default.
• W2003812977 hasLocation W20038129771 @default.
• W2003812977 hasLocation W20038129772 @default.
• W2003812977 hasOpenAccess W2003812977 @default.
• W2003812977 hasPrimaryLocation W20038129771 @default.
• W2003812977 hasRelatedWork W1569421095 @default.
• W2003812977 hasRelatedWork W1973036726 @default.
• W2003812977 hasRelatedWork W1980718559 @default.

• next