FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003813423> ?p ?o ?g. }

• W2003813423 endingPage "548" @default.
• W2003813423 startingPage "539" @default.
• W2003813423 abstract "A number of cancer chemotherapeutic agents have been associated with a loss of memory in breast cancer patients although little is known of the causality of this effect. To assess the potential cognitive effects of repeated exposure to chemotherapeutic agents, we administered the selective estrogen receptor modulator tamoxifen or the antimetabolite chemotherapy, methotrexate, and 5-fluorouracil, alone and in combination to mice and tested them in a learning and memory assay. Swiss-Webster male mice were injected with saline, 32 mg/kg tamoxifen, 3.2 or 32 mg/kg methotrexate, 75 mg/kg 5-fluorouracil, 3.2 or 32 mg/kg methotrexate in combination with 75 mg/kg 5-fluorouracil once per week for 3 weeks. On days 23 and 24, mice were tested for acquisition and retention of a nose-poke response in a learning procedure called autoshaping. In addition, the acute effects of tamoxifen were assessed in additional mice in a similar procedure. The chemotherapeutic agents alone and in combination reduced body weight relative to saline treatment over the course of 4 weeks. Repeated treatment with tamoxifen produced both acquisition and retention effects relative to the saline-treated group although acute tamoxifen was without effect except at a behaviorally toxic dose. Repeated treatment with methotrexate in combination with 5-fluorouracil produced effects on retention, but the magnitude of these changes depended on the methotrexate dose. These data demonstrate that repeated administration of tamoxifen or certain combination of methotrexate and 5-fluorouracil may produce deficits in the acquisition or retention of learned responses which suggest potential strategies for prevention or remediation might be considered in vulnerable patient populations." @default.
• W2003813423 created "2016-06-24" @default.
• W2003813423 creator A5040742923 @default.
• W2003813423 creator A5050172136 @default.
• W2003813423 creator A5067718462 @default.
• W2003813423 creator A5077593052 @default.
• W2003813423 date "2011-05-03" @default.
• W2003813423 modified "2023-10-16" @default.
• W2003813423 title "Effects of repeated administration of chemotherapeutic agents tamoxifen, methotrexate, and 5-fluorouracil on the acquisition and retention of a learned response in mice" @default.
• W2003813423 cites W1750906271 @default.
• W2003813423 cites W182334483 @default.
• W2003813423 cites W1847137107 @default.
• W2003813423 cites W1965632938 @default.
• W2003813423 cites W1966022908 @default.
• W2003813423 cites W1966541591 @default.
• W2003813423 cites W1971843598 @default.
• W2003813423 cites W1988794939 @default.
• W2003813423 cites W1989290120 @default.
• W2003813423 cites W1989336541 @default.
• W2003813423 cites W1989789824 @default.
• W2003813423 cites W2002617950 @default.
• W2003813423 cites W2005505522 @default.
• W2003813423 cites W2020840338 @default.
• W2003813423 cites W2027781855 @default.
• W2003813423 cites W2038973587 @default.
• W2003813423 cites W2039493397 @default.
• W2003813423 cites W2041482526 @default.
• W2003813423 cites W2047479351 @default.
• W2003813423 cites W2049180305 @default.
• W2003813423 cites W2053030019 @default.
• W2003813423 cites W2056184703 @default.
• W2003813423 cites W2056804370 @default.
• W2003813423 cites W2057028002 @default.
• W2003813423 cites W2066412951 @default.
• W2003813423 cites W2085894888 @default.
• W2003813423 cites W2089417668 @default.
• W2003813423 cites W2090664057 @default.
• W2003813423 cites W2092544539 @default.
• W2003813423 cites W2096054535 @default.
• W2003813423 cites W2097717839 @default.
• W2003813423 cites W2098757634 @default.
• W2003813423 cites W2109083500 @default.
• W2003813423 cites W2115575621 @default.
• W2003813423 cites W2125955497 @default.
• W2003813423 cites W2130235602 @default.
• W2003813423 cites W2133244075 @default.
• W2003813423 cites W2136923586 @default.
• W2003813423 cites W2139056718 @default.
• W2003813423 cites W2140772483 @default.
• W2003813423 cites W2148153690 @default.
• W2003813423 cites W2150070918 @default.
• W2003813423 cites W2150329556 @default.
• W2003813423 cites W2152709121 @default.
• W2003813423 cites W2159144006 @default.
• W2003813423 cites W2164131844 @default.
• W2003813423 cites W2396377009 @default.
• W2003813423 cites W4239415619 @default.
• W2003813423 doi "https://doi.org/10.1007/s00213-011-2310-8" @default.
• W2003813423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3249240" @default.
• W2003813423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21537942" @default.
• W2003813423 hasPublicationYear "2011" @default.
• W2003813423 type Work @default.
• W2003813423 sameAs 2003813423 @default.
• W2003813423 citedByCount "41" @default.
• W2003813423 countsByYear W20038134232012 @default.
• W2003813423 countsByYear W20038134232013 @default.
• W2003813423 countsByYear W20038134232014 @default.
• W2003813423 countsByYear W20038134232015 @default.
• W2003813423 countsByYear W20038134232016 @default.
• W2003813423 countsByYear W20038134232017 @default.
• W2003813423 countsByYear W20038134232018 @default.
• W2003813423 countsByYear W20038134232019 @default.
• W2003813423 countsByYear W20038134232020 @default.
• W2003813423 countsByYear W20038134232021 @default.
• W2003813423 countsByYear W20038134232022 @default.
• W2003813423 countsByYear W20038134232023 @default.
• W2003813423 crossrefType "journal-article" @default.
• W2003813423 hasAuthorship W2003813423A5040742923 @default.
• W2003813423 hasAuthorship W2003813423A5050172136 @default.
• W2003813423 hasAuthorship W2003813423A5067718462 @default.
• W2003813423 hasAuthorship W2003813423A5077593052 @default.
• W2003813423 hasBestOaLocation W20038134232 @default.
• W2003813423 hasConcept C121608353 @default.
• W2003813423 hasConcept C126322002 @default.
• W2003813423 hasConcept C2776694085 @default.
• W2003813423 hasConcept C2777176818 @default.
• W2003813423 hasConcept C2777397205 @default.
• W2003813423 hasConcept C2778397455 @default.
• W2003813423 hasConcept C2780456651 @default.
• W2003813423 hasConcept C2781059491 @default.
• W2003813423 hasConcept C530470458 @default.
• W2003813423 hasConcept C71924100 @default.
• W2003813423 hasConcept C98274493 @default.
• W2003813423 hasConceptScore W2003813423C121608353 @default.
• W2003813423 hasConceptScore W2003813423C126322002 @default.
• W2003813423 hasConceptScore W2003813423C2776694085 @default.
• W2003813423 hasConceptScore W2003813423C2777176818 @default.
• W2003813423 hasConceptScore W2003813423C2777397205 @default.

• next