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• W2003816758 abstract "Rabbit platelet membranes, preincubated with 3H-labeled platelet activating factor ([3H]PAF), were solubilized with 2% digitonin. Sedimentation of the detergent extract in a sucrose density gradient revealed a major labeled component with a sedimentation coefficient (s20,omega) of 10.5 S, which was substantially diminished when an excess of unlabeled PAF or L-652,731, (trans-2,5-bis(3,4,5-trimethoxyphenyl)tetrahydrofuran), (PAF antagonist) was present in the preincubation mixture, suggesting that the 10.5 S component is a specific receptor-bound [3H]PAF complex. Gel filtration of the [3H]PAF-receptor complex on Sephacryl S-300 revealed a single radiolabeled fraction with an apparent Stokes' radius of 4.9 nm. The apparent molecular weight and the frictional ratio of the agonist-receptor complex were computed to be 220,000 and 1.13, respectively. Dissociation of [3H]PAF from the radioligand-receptor complex was facilitated by Na+ and Li+, whereas K+ and Cs+ were ineffective. The guanine nucleotide, GTP, was also found to promote the dissociation in a manner that is additive with the effect of Na+, suggestive of the coupling of a guanine nucleotide binding protein to the solubilized PAF-receptor complex." @default.
• W2003816758 created "2016-06-24" @default.
• W2003816758 creator A5010806811 @default.
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• W2003816758 date "1988-06-01" @default.
• W2003816758 modified "2023-10-16" @default.
• W2003816758 title "Characterization of3H-labelled platelet activating factor receptor complex solubilized from rabbit platelet membranes" @default.
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• W2003816758 doi "https://doi.org/10.1016/0167-4889(88)90168-1" @default.
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• W2003816758 hasPublicationYear "1988" @default.
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