FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003818435> ?p ?o ?g. }

• W2003818435 endingPage "2674" @default.
• W2003818435 startingPage "2664" @default.
• W2003818435 abstract "We previously reported the safety and efficacy in animal experiments of transcutaneous immunization (TCI) using a self-dissolving microneedle patch (MicroHyala; MH) made of hyaluronic acid and collagen. However, this MH was an unsuitable TCI device for the human skin, as collagen is suspected to induce inflammation. In this study, we developed an improved collagen-free MH (new-MH) and conducted clinical study to evaluate the fundamental properties and safety in human. Microneedle dissolution, skin irritation, and antigen-specific antibody production about new-MH were measured in mice and/or rats. On the basis of the results, the clinical study was conducted in healthy volunteers to evaluate local and systemic adverse events caused by new-MH application. We confirmed that the microneedles of new-MH, as well as those on our old-MH that contained collagen, could easily pierce stratum corneum without severe skin irritation, and that TCI using new-MH efficiently increased antibody titer with comparable to TCI using old-MH. Application of new-MH caused no severe adverse reactions in 20 healthy volunteers enrolled in a clinical study. These results verified that new-MH is a safe TCI device in human, and greatly encouraged us to advance PI/PII clinical studies of antigen-loaded new-MH." @default.
• W2003818435 created "2016-06-24" @default.
• W2003818435 creator A5000674250 @default.
• W2003818435 creator A5012563609 @default.
• W2003818435 creator A5018050076 @default.
• W2003818435 creator A5034746360 @default.
• W2003818435 creator A5051132319 @default.
• W2003818435 creator A5055701247 @default.
• W2003818435 creator A5066600229 @default.
• W2003818435 creator A5069468154 @default.
• W2003818435 creator A5072978499 @default.
• W2003818435 creator A5081922960 @default.
• W2003818435 date "2013-06-18" @default.
• W2003818435 modified "2023-10-17" @default.
• W2003818435 title "Development and Clinical Study of a Self-Dissolving Microneedle Patch for Transcutaneous Immunization Device" @default.
• W2003818435 cites W1599778534 @default.
• W2003818435 cites W1978627569 @default.
• W2003818435 cites W1981760171 @default.
• W2003818435 cites W1986713756 @default.
• W2003818435 cites W1996484138 @default.
• W2003818435 cites W1997246404 @default.
• W2003818435 cites W2002280961 @default.
• W2003818435 cites W2004752806 @default.
• W2003818435 cites W2012518985 @default.
• W2003818435 cites W2013315584 @default.
• W2003818435 cites W2021970178 @default.
• W2003818435 cites W2025588860 @default.
• W2003818435 cites W2026053680 @default.
• W2003818435 cites W2033198837 @default.
• W2003818435 cites W2066691015 @default.
• W2003818435 cites W2075001207 @default.
• W2003818435 cites W2081159973 @default.
• W2003818435 cites W2081385502 @default.
• W2003818435 cites W2089115481 @default.
• W2003818435 cites W2089143024 @default.
• W2003818435 cites W2090889765 @default.
• W2003818435 cites W2093014785 @default.
• W2003818435 cites W2093577750 @default.
• W2003818435 cites W2094028486 @default.
• W2003818435 cites W2099598044 @default.
• W2003818435 cites W2119384523 @default.
• W2003818435 cites W2124215162 @default.
• W2003818435 cites W2157261600 @default.
• W2003818435 cites W2885377581 @default.
• W2003818435 doi "https://doi.org/10.1007/s11095-013-1092-6" @default.
• W2003818435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23775442" @default.
• W2003818435 hasPublicationYear "2013" @default.
• W2003818435 type Work @default.
• W2003818435 sameAs 2003818435 @default.
• W2003818435 citedByCount "83" @default.
• W2003818435 countsByYear W20038184352014 @default.
• W2003818435 countsByYear W20038184352015 @default.
• W2003818435 countsByYear W20038184352016 @default.
• W2003818435 countsByYear W20038184352017 @default.
• W2003818435 countsByYear W20038184352018 @default.
• W2003818435 countsByYear W20038184352019 @default.
• W2003818435 countsByYear W20038184352020 @default.
• W2003818435 countsByYear W20038184352021 @default.
• W2003818435 countsByYear W20038184352022 @default.
• W2003818435 countsByYear W20038184352023 @default.
• W2003818435 crossrefType "journal-article" @default.
• W2003818435 hasAuthorship W2003818435A5000674250 @default.
• W2003818435 hasAuthorship W2003818435A5012563609 @default.
• W2003818435 hasAuthorship W2003818435A5018050076 @default.
• W2003818435 hasAuthorship W2003818435A5034746360 @default.
• W2003818435 hasAuthorship W2003818435A5051132319 @default.
• W2003818435 hasAuthorship W2003818435A5055701247 @default.
• W2003818435 hasAuthorship W2003818435A5066600229 @default.
• W2003818435 hasAuthorship W2003818435A5069468154 @default.
• W2003818435 hasAuthorship W2003818435A5072978499 @default.
• W2003818435 hasAuthorship W2003818435A5081922960 @default.
• W2003818435 hasBestOaLocation W20038184351 @default.
• W2003818435 hasConcept C105702510 @default.
• W2003818435 hasConcept C141071460 @default.
• W2003818435 hasConcept C142724271 @default.
• W2003818435 hasConcept C159654299 @default.
• W2003818435 hasConcept C16005928 @default.
• W2003818435 hasConcept C197934379 @default.
• W2003818435 hasConcept C203014093 @default.
• W2003818435 hasConcept C22889606 @default.
• W2003818435 hasConcept C2777063393 @default.
• W2003818435 hasConcept C2777459323 @default.
• W2003818435 hasConcept C2777529286 @default.
• W2003818435 hasConcept C2778370115 @default.
• W2003818435 hasConcept C3019129585 @default.
• W2003818435 hasConcept C3019592751 @default.
• W2003818435 hasConcept C32611913 @default.
• W2003818435 hasConcept C54355233 @default.
• W2003818435 hasConcept C71924100 @default.
• W2003818435 hasConcept C86803240 @default.
• W2003818435 hasConcept C98274493 @default.
• W2003818435 hasConceptScore W2003818435C105702510 @default.
• W2003818435 hasConceptScore W2003818435C141071460 @default.
• W2003818435 hasConceptScore W2003818435C142724271 @default.
• W2003818435 hasConceptScore W2003818435C159654299 @default.
• W2003818435 hasConceptScore W2003818435C16005928 @default.
• W2003818435 hasConceptScore W2003818435C197934379 @default.
• W2003818435 hasConceptScore W2003818435C203014093 @default.

• next