Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003819574> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2003819574 endingPage "169" @default.
- W2003819574 startingPage "161" @default.
- W2003819574 abstract "By differential hybridization, three complementary DNAs designated as S3, S2, and SA were isolated, and the corresponding messenger RNAs (mRNAs) were differentially expressed between the kidneys of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. S3 is identical to cytochrome P450 IV A2. SA encoded a protein of 546 amino acid residues, and its carboxyl terminal region had a slight homology to luciferase. No homologous sequence has been reported in S2 sequences. S3 mRNA was about four times more abundantly expressed in the kidneys of 28-day-old SHR than in those of age-matched WKY rats, but there was no difference at age 16 weeks. A low NaCl diet positively modulated the expression of the S3 gene. S2 mRNA was almost undetectable in the kidneys of 28-day-old WKY rats but was clearly detected in those of age-matched SHR. The expression level of S2 mRNA in the livers of 16-week-old SHR was about five times higher than that of age-matched WKY rats. The expression of S2 mRNA in the livers was modulated by dietary NaCl and captopril. SA mRNA was more than 10 times more abundantly expressed in the kidneys of SHR than in those of WKY rats from age 4 weeks. With the administration of captopril, the expressions of SA mRNA in the livers of SHR were positively modulated. Because these three genes are not only differentially expressed between SHR and WKY rats but also related to sodium metabolism or blood pressure control, the identification of these genes may provide important probes to examine the mechanisms of hypertension." @default.
- W2003819574 created "2016-06-24" @default.
- W2003819574 creator A5039090244 @default.
- W2003819574 creator A5088216068 @default.
- W2003819574 date "1991-02-01" @default.
- W2003819574 modified "2023-10-13" @default.
- W2003819574 title "Isolation of preferentially expressed genes in the kidneys of hypertensive rats." @default.
- W2003819574 cites W16259457 @default.
- W2003819574 cites W1726146786 @default.
- W2003819574 cites W1987329604 @default.
- W2003819574 cites W2027063965 @default.
- W2003819574 cites W2035370019 @default.
- W2003819574 cites W2045348184 @default.
- W2003819574 cites W2045822258 @default.
- W2003819574 cites W2060333964 @default.
- W2003819574 cites W2084234371 @default.
- W2003819574 cites W2091239909 @default.
- W2003819574 cites W2092885497 @default.
- W2003819574 cites W2093542639 @default.
- W2003819574 cites W2096611980 @default.
- W2003819574 cites W2097794242 @default.
- W2003819574 cites W2155193020 @default.
- W2003819574 doi "https://doi.org/10.1161/01.hyp.17.2.161" @default.
- W2003819574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1991648" @default.
- W2003819574 hasPublicationYear "1991" @default.
- W2003819574 type Work @default.
- W2003819574 sameAs 2003819574 @default.
- W2003819574 citedByCount "161" @default.
- W2003819574 countsByYear W20038195742014 @default.
- W2003819574 countsByYear W20038195742015 @default.
- W2003819574 countsByYear W20038195742017 @default.
- W2003819574 countsByYear W20038195742018 @default.
- W2003819574 countsByYear W20038195742019 @default.
- W2003819574 countsByYear W20038195742020 @default.
- W2003819574 countsByYear W20038195742022 @default.
- W2003819574 countsByYear W20038195742023 @default.
- W2003819574 crossrefType "journal-article" @default.
- W2003819574 hasAuthorship W2003819574A5039090244 @default.
- W2003819574 hasAuthorship W2003819574A5088216068 @default.
- W2003819574 hasBestOaLocation W20038195741 @default.
- W2003819574 hasConcept C104317684 @default.
- W2003819574 hasConcept C105580179 @default.
- W2003819574 hasConcept C126322002 @default.
- W2003819574 hasConcept C134018914 @default.
- W2003819574 hasConcept C150194340 @default.
- W2003819574 hasConcept C2778086073 @default.
- W2003819574 hasConcept C2779479957 @default.
- W2003819574 hasConcept C2780091579 @default.
- W2003819574 hasConcept C55493867 @default.
- W2003819574 hasConcept C71924100 @default.
- W2003819574 hasConcept C84393581 @default.
- W2003819574 hasConcept C86803240 @default.
- W2003819574 hasConceptScore W2003819574C104317684 @default.
- W2003819574 hasConceptScore W2003819574C105580179 @default.
- W2003819574 hasConceptScore W2003819574C126322002 @default.
- W2003819574 hasConceptScore W2003819574C134018914 @default.
- W2003819574 hasConceptScore W2003819574C150194340 @default.
- W2003819574 hasConceptScore W2003819574C2778086073 @default.
- W2003819574 hasConceptScore W2003819574C2779479957 @default.
- W2003819574 hasConceptScore W2003819574C2780091579 @default.
- W2003819574 hasConceptScore W2003819574C55493867 @default.
- W2003819574 hasConceptScore W2003819574C71924100 @default.
- W2003819574 hasConceptScore W2003819574C84393581 @default.
- W2003819574 hasConceptScore W2003819574C86803240 @default.
- W2003819574 hasIssue "2" @default.
- W2003819574 hasLocation W20038195741 @default.
- W2003819574 hasLocation W20038195742 @default.
- W2003819574 hasOpenAccess W2003819574 @default.
- W2003819574 hasPrimaryLocation W20038195741 @default.
- W2003819574 hasRelatedWork W1994918206 @default.
- W2003819574 hasRelatedWork W2062844910 @default.
- W2003819574 hasRelatedWork W2125928046 @default.
- W2003819574 hasRelatedWork W2137280317 @default.
- W2003819574 hasRelatedWork W2362348557 @default.
- W2003819574 hasRelatedWork W2370319703 @default.
- W2003819574 hasRelatedWork W2370778587 @default.
- W2003819574 hasRelatedWork W2413002684 @default.
- W2003819574 hasRelatedWork W4301147648 @default.
- W2003819574 hasRelatedWork W1992235670 @default.
- W2003819574 hasVolume "17" @default.
- W2003819574 isParatext "false" @default.
- W2003819574 isRetracted "false" @default.
- W2003819574 magId "2003819574" @default.
- W2003819574 workType "article" @default.