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• W2003820110 abstract "The lipid phosphatase SHIP2 (SH2 domain containing inositol 5-phosphatase 2) has recently been shown to be a potent negative regulator of insulin signaling and insulin sensitivity in vivo. We show here that SHIP2 is expressed in Chinese hamster ovary cells overexpressing the insulin receptor (CHO-IR cells) and tyrosine phosphorylated upon insulin stimulation. We show that SHIP2, which is recruited in anti-phosphotyrosine immunoprecipitates in insulin-stimulated cells, accounts for the insulin sensitivity or apparent increase in activity reported by Guilherme et al. (J. Biol. Chem. 271, 29533-29536, 1996). Overexpression of SHIP2 led to a decrease of the insulin-dependent PIP3 production as well as Akt/PKB activation and MAPK stimulation." @default.
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• W2003820110 date "2001-04-01" @default.
• W2003820110 modified "2023-10-14" @default.
• W2003820110 title "The SH2 Domain Containing Inositol 5-Phosphatase SHIP2 Controls Phosphatidylinositol 3,4,5-Trisphosphate Levels in CHO-IR Cells Stimulated by Insulin" @default.
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• W2003820110 doi "https://doi.org/10.1006/bbrc.2001.4639" @default.
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