FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003849655> ?p ?o ?g. }

• W2003849655 endingPage "959" @default.
• W2003849655 startingPage "944" @default.
• W2003849655 abstract "Elisidepsin (PM02734, Irvalec®) is a synthetic marine-derived cyclic peptide of the Kahalalide F family currently in phase II clinical development. Elisidepsin was shown to induce rapid oncosis in ErbB3-expressing cells. Other predictive factors of elisidepsin sensitivity remained unknown. A panel of 23 cancer cell lines of different origin was assessed for elisidepsin cytotoxicity and correlated with mutational state, mRNA and protein expression of selected genes. Elisidepsin showed potent and broad cytotoxic effects in our cancer cell line panel, being active at concentrations ranging from 0.4 to 2 μM that may be relevant for clinical settings. We have shown that elisidepsin is more active in cells harboring epithelial phenotype with high E-cadherin and low vimentin expression. In addition, high ErbB3 and Muc1 expression was correlated with sensitivity to elisidepsin, whereas the presence of KRAS activating mutations was associated with resistance. In DU-PM cells with acquired resistance to elisidepsin, ErbB3 expression was decreased, while Bcl2 was increased. DU-PM cells displayed higher sensitivity to ErbB1-inhibitors suggesting possible cross-talk of ErbB1 and ErbB3 signaling pathways. Combinations of elisidepsin with lapatinib and several chemotherapies including 5-FU and oxaliplatin resulted in synergistic effects that offer the potential of clinical use of elisidepsin in combination settings." @default.
• W2003849655 created "2016-06-24" @default.
• W2003849655 creator A5002864173 @default.
• W2003849655 creator A5013952219 @default.
• W2003849655 creator A5020206768 @default.
• W2003849655 creator A5035047505 @default.
• W2003849655 creator A5037675253 @default.
• W2003849655 creator A5037964830 @default.
• W2003849655 creator A5042876168 @default.
• W2003849655 creator A5063395534 @default.
• W2003849655 creator A5082106706 @default.
• W2003849655 date "2013-03-20" @default.
• W2003849655 modified "2023-10-14" @default.
• W2003849655 title "Predictive Factors of Sensitivity to Elisidepsin, a Novel Kahalalide F-Derived Marine Compound" @default.
• W2003849655 cites W1517548121 @default.
• W2003849655 cites W1972237128 @default.
• W2003849655 cites W1975658757 @default.
• W2003849655 cites W1979866869 @default.
• W2003849655 cites W1993804787 @default.
• W2003849655 cites W2017453518 @default.
• W2003849655 cites W2040964625 @default.
• W2003849655 cites W2041021320 @default.
• W2003849655 cites W2045228443 @default.
• W2003849655 cites W2059498883 @default.
• W2003849655 cites W2062983115 @default.
• W2003849655 cites W2077945404 @default.
• W2003849655 cites W2079078449 @default.
• W2003849655 cites W2088240599 @default.
• W2003849655 cites W2100751052 @default.
• W2003849655 cites W2109116257 @default.
• W2003849655 cites W2114918609 @default.
• W2003849655 cites W2128124261 @default.
• W2003849655 cites W2142472437 @default.
• W2003849655 cites W2142681992 @default.
• W2003849655 cites W2164914395 @default.
• W2003849655 cites W2246542333 @default.
• W2003849655 cites W2426974342 @default.
• W2003849655 cites W3023108205 @default.
• W2003849655 doi "https://doi.org/10.3390/md11030944" @default.
• W2003849655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3705381" @default.
• W2003849655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23519149" @default.
• W2003849655 hasPublicationYear "2013" @default.
• W2003849655 type Work @default.
• W2003849655 sameAs 2003849655 @default.
• W2003849655 citedByCount "35" @default.
• W2003849655 countsByYear W20038496552013 @default.
• W2003849655 countsByYear W20038496552014 @default.
• W2003849655 countsByYear W20038496552015 @default.
• W2003849655 countsByYear W20038496552016 @default.
• W2003849655 countsByYear W20038496552017 @default.
• W2003849655 countsByYear W20038496552018 @default.
• W2003849655 countsByYear W20038496552019 @default.
• W2003849655 countsByYear W20038496552020 @default.
• W2003849655 countsByYear W20038496552021 @default.
• W2003849655 countsByYear W20038496552022 @default.
• W2003849655 countsByYear W20038496552023 @default.
• W2003849655 crossrefType "journal-article" @default.
• W2003849655 hasAuthorship W2003849655A5002864173 @default.
• W2003849655 hasAuthorship W2003849655A5013952219 @default.
• W2003849655 hasAuthorship W2003849655A5020206768 @default.
• W2003849655 hasAuthorship W2003849655A5035047505 @default.
• W2003849655 hasAuthorship W2003849655A5037675253 @default.
• W2003849655 hasAuthorship W2003849655A5037964830 @default.
• W2003849655 hasAuthorship W2003849655A5042876168 @default.
• W2003849655 hasAuthorship W2003849655A5063395534 @default.
• W2003849655 hasAuthorship W2003849655A5082106706 @default.
• W2003849655 hasBestOaLocation W20038496551 @default.
• W2003849655 hasConcept C104317684 @default.
• W2003849655 hasConcept C109316439 @default.
• W2003849655 hasConcept C115456853 @default.
• W2003849655 hasConcept C121608353 @default.
• W2003849655 hasConcept C127716648 @default.
• W2003849655 hasConcept C153911025 @default.
• W2003849655 hasConcept C154317977 @default.
• W2003849655 hasConcept C185592680 @default.
• W2003849655 hasConcept C202751555 @default.
• W2003849655 hasConcept C2777329042 @default.
• W2003849655 hasConcept C2779251935 @default.
• W2003849655 hasConcept C2779438470 @default.
• W2003849655 hasConcept C2779786085 @default.
• W2003849655 hasConcept C2780962732 @default.
• W2003849655 hasConcept C2781187634 @default.
• W2003849655 hasConcept C502942594 @default.
• W2003849655 hasConcept C526805850 @default.
• W2003849655 hasConcept C530470458 @default.
• W2003849655 hasConcept C54355233 @default.
• W2003849655 hasConcept C62478195 @default.
• W2003849655 hasConcept C81885089 @default.
• W2003849655 hasConcept C86803240 @default.
• W2003849655 hasConcept C95444343 @default.
• W2003849655 hasConcept C96232424 @default.
• W2003849655 hasConceptScore W2003849655C104317684 @default.
• W2003849655 hasConceptScore W2003849655C109316439 @default.
• W2003849655 hasConceptScore W2003849655C115456853 @default.
• W2003849655 hasConceptScore W2003849655C121608353 @default.
• W2003849655 hasConceptScore W2003849655C127716648 @default.
• W2003849655 hasConceptScore W2003849655C153911025 @default.
• W2003849655 hasConceptScore W2003849655C154317977 @default.

• next