FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003853612> ?p ?o ?g. }

• W2003853612 endingPage "104" @default.
• W2003853612 startingPage "89" @default.
• W2003853612 abstract "We have identified an avian oncovirus-specific polypeptide of 120,000 dalton molecular weight (P120) in extracts of uninfected chick embryo fibroblast cells (CEF). P120 can be detected in CEF positive for the expression of avian oncovirus group-specific antigen (gs+), but its presence cannot be correlated with phenotypic expression of endogenous oncovirus envelope glycoprotein (chf). Immune precipitation experiments indicate that P120 contains antigenic determinants of the virion core proteins (products of the gag gene) and reverse transcriptase, but not of the envelope glycoprotein gp85. Double-label ion-exchange chromatography of tryptic digests of P120 reveals that this polypeptide contains amino acid sequences related to the virion core proteins p270, p19 and p12 of the chicken endogenous virus RAV-0, but lacks the tryptic peptides of p15. In addition, P120 contains three tryptic peptides which appear to be present in both the α and β subunits of reverse transcriptase. The order of the tryptic peptides on P120 was determined using the pactamycin procedure. The data demonstrate that the P120 tryptic peptides which are presumed to be related to reverse transcriptase lie between the gag region and the carboxy terminus of the protein. Our data are consistent with the idea that P120 is equivalent to a gag-pol polyprotein that is missing both p15 and significant portions of reverse transcriptase. In pulse-chase experiments, P120 does not appear to be specifically cleaved to generate virion structural proteins. Furthermore, we have been unable to detect P120 in RAV-0 producing line 7 and line 15 CEF. Instead, only Pr76gag (the direct precusor to virion core proteins in productively infected cells) is observed in these cells. Thus P120 is unlikely to act as a functional intermediate in virus maturation. We have also observed that infection of gs+ CEF with exogenous avian sarcoma and leukemia viruses results in a significant but variable decrease in the level of P120." @default.
• W2003853612 created "2016-06-24" @default.
• W2003853612 creator A5006668202 @default.
• W2003853612 creator A5040551965 @default.
• W2003853612 creator A5082542184 @default.
• W2003853612 date "1978-05-01" @default.
• W2003853612 modified "2023-10-01" @default.
• W2003853612 title "Identification of an avian oncovirus polyprotein in uninfected chick cells" @default.
• W2003853612 cites W1492044589 @default.
• W2003853612 cites W1524374483 @default.
• W2003853612 cites W1542870322 @default.
• W2003853612 cites W1548257670 @default.
• W2003853612 cites W1556158097 @default.
• W2003853612 cites W1559803121 @default.
• W2003853612 cites W1563272873 @default.
• W2003853612 cites W1578211649 @default.
• W2003853612 cites W1588885776 @default.
• W2003853612 cites W1636224566 @default.
• W2003853612 cites W1641258988 @default.
• W2003853612 cites W1732105733 @default.
• W2003853612 cites W1750012585 @default.
• W2003853612 cites W1822663461 @default.
• W2003853612 cites W1964149773 @default.
• W2003853612 cites W1965030902 @default.
• W2003853612 cites W1967867764 @default.
• W2003853612 cites W1969473460 @default.
• W2003853612 cites W1972991811 @default.
• W2003853612 cites W1983109752 @default.
• W2003853612 cites W1989618944 @default.
• W2003853612 cites W1992893612 @default.
• W2003853612 cites W1993107089 @default.
• W2003853612 cites W2004730835 @default.
• W2003853612 cites W2007302020 @default.
• W2003853612 cites W2014027374 @default.
• W2003853612 cites W2015101848 @default.
• W2003853612 cites W2020175571 @default.
• W2003853612 cites W2023333602 @default.
• W2003853612 cites W2030458738 @default.
• W2003853612 cites W2039234170 @default.
• W2003853612 cites W2041655318 @default.
• W2003853612 cites W2043694838 @default.
• W2003853612 cites W2047056225 @default.
• W2003853612 cites W2063085217 @default.
• W2003853612 cites W2063470561 @default.
• W2003853612 cites W2070680229 @default.
• W2003853612 cites W2076423417 @default.
• W2003853612 cites W2100837269 @default.
• W2003853612 cites W2101849912 @default.
• W2003853612 cites W2106671927 @default.
• W2003853612 cites W2114805139 @default.
• W2003853612 cites W2137072736 @default.
• W2003853612 cites W2162212719 @default.
• W2003853612 cites W2165492599 @default.
• W2003853612 doi "https://doi.org/10.1016/0092-8674(78)90304-5" @default.
• W2003853612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/78765" @default.
• W2003853612 hasPublicationYear "1978" @default.
• W2003853612 type Work @default.
• W2003853612 sameAs 2003853612 @default.
• W2003853612 citedByCount "51" @default.
• W2003853612 crossrefType "journal-article" @default.
• W2003853612 hasAuthorship W2003853612A5006668202 @default.
• W2003853612 hasAuthorship W2003853612A5040551965 @default.
• W2003853612 hasAuthorship W2003853612A5082542184 @default.
• W2003853612 hasConcept C104317684 @default.
• W2003853612 hasConcept C108625454 @default.
• W2003853612 hasConcept C121346293 @default.
• W2003853612 hasConcept C141231307 @default.
• W2003853612 hasConcept C147483822 @default.
• W2003853612 hasConcept C153911025 @default.
• W2003853612 hasConcept C156719811 @default.
• W2003853612 hasConcept C159047783 @default.
• W2003853612 hasConcept C515207424 @default.
• W2003853612 hasConcept C54355233 @default.
• W2003853612 hasConcept C55493867 @default.
• W2003853612 hasConcept C67705224 @default.
• W2003853612 hasConcept C86803240 @default.
• W2003853612 hasConceptScore W2003853612C104317684 @default.
• W2003853612 hasConceptScore W2003853612C108625454 @default.
• W2003853612 hasConceptScore W2003853612C121346293 @default.
• W2003853612 hasConceptScore W2003853612C141231307 @default.
• W2003853612 hasConceptScore W2003853612C147483822 @default.
• W2003853612 hasConceptScore W2003853612C153911025 @default.
• W2003853612 hasConceptScore W2003853612C156719811 @default.
• W2003853612 hasConceptScore W2003853612C159047783 @default.
• W2003853612 hasConceptScore W2003853612C515207424 @default.
• W2003853612 hasConceptScore W2003853612C54355233 @default.
• W2003853612 hasConceptScore W2003853612C55493867 @default.
• W2003853612 hasConceptScore W2003853612C67705224 @default.
• W2003853612 hasConceptScore W2003853612C86803240 @default.
• W2003853612 hasIssue "1" @default.
• W2003853612 hasLocation W20038536121 @default.
• W2003853612 hasLocation W20038536122 @default.
• W2003853612 hasOpenAccess W2003853612 @default.
• W2003853612 hasPrimaryLocation W20038536121 @default.
• W2003853612 hasRelatedWork W1516164909 @default.
• W2003853612 hasRelatedWork W1527215315 @default.
• W2003853612 hasRelatedWork W1648368577 @default.
• W2003853612 hasRelatedWork W1966013139 @default.

• next