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- W2003855587 abstract "Peripheral injections of resiniferatoxin (RTX) can be used to achieve analgesia by temporarily removing TRPV1-expressing pain fibers. A goal of the present study was to determine the minimal amount of RTX needed to obtain hypoalgesia. Additionally, we sought to determine whether C-fibers and A-delta type II fibers are differentially affected by RTX. Using a laser to stimulate rat hind paws, we observed that 0.5 ng failed to induce hypoalgesia, whereas 5.0 ng and 50 ng resulted in C-fiber hypoalgesia for nearly 2 weeks. When observing A-delta type II fiber response, both 5 and 50 ng injections resulted in potent hypoalgesia within the first week whereas no hypoalgesia was observed with the vehicle and 0.5 ng injections. Unexpectedly, A-delta type II hypoalgesia remained for as long as 2 months, although there was a partial return of behavior. Molecularly, we observed that mRNA encoding ATF-3 and galanin, markers of regeneration, were dramatically increased in the dorsal root ganglia (DRG) 24 h and 10d after RTX injection. In contrast, the transcript encoding MCP-1, a putative indicator of nociception when induced in DRG, was significantly elevated by 24 h but returned immediately thereafter. In the spinal cord, increased expression of c-Fos protein was detected by 6h but returned to baseline by 24 h. Taken together, these data indicate that the more prolonged hypoalgesic response for A-delta type II is due to a slowed regeneration as compared to C-fibers." @default.
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- W2003855587 date "2010-04-01" @default.
- W2003855587 modified "2023-09-25" @default.
- W2003855587 title "Prolonged analgesic effect of RTX on A-delta type II fibers following peripheral administration" @default.
- W2003855587 doi "https://doi.org/10.1016/j.jpain.2010.01.170" @default.
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