FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003869969> ?p ?o ?g. }

• W2003869969 endingPage "2420" @default.
• W2003869969 startingPage "2415" @default.
• W2003869969 abstract "Osteosarcoma, which is the most common type of highly malignant bone tumor in children and adolescents, has poor diagnosis and 2-year survival rates of 15-20% following surgery or radiotherapy, and has therefore generated marked attention. In order to investigate the potential biomarkers for diagnosing osteosarcoma, the expression profiling data from normal and disease tissues were compared, respectively, and the differentially‑expressed genes were analyzed by three different statistical tests. Interacting proteins were determined and an interaction network was constructed by Search Tool for the Retrieval of Interacting Genes database. Subsequently, the protein interaction network was decomposed and Gene Otology annotation using Cytoscape, Mcode and Bingo, was conducted on the function modules. Finally, three differentially‑expressed genes GJA1, COL1A2 and COL5A2 were identified, and an interaction network was successfully generated with COL1A2 and COL5A2 at the core. From the results, it was observed that COL1A2 and COL5A2 interact with a number of genes of the matrix metalloprotease (MMP) family, including MMP1, MMP2, MMP3 and MMP14, TGFβ and RUNX2. Furthermore, these genes have been confirmed to be important in the tumorigenesis of osteosarcoma. It was hypothesized that the upregulation of the COL gene family may be considered as a diagnostic marker for osteosarcoma and collagen may be administered as a therapy." @default.
• W2003869969 created "2016-06-24" @default.
• W2003869969 creator A5001746337 @default.
• W2003869969 creator A5012319990 @default.
• W2003869969 creator A5021384155 @default.
• W2003869969 creator A5025838203 @default.
• W2003869969 creator A5059911678 @default.
• W2003869969 creator A5074339191 @default.
• W2003869969 creator A5080477696 @default.
• W2003869969 creator A5084677096 @default.
• W2003869969 date "2014-09-08" @default.
• W2003869969 modified "2023-10-14" @default.
• W2003869969 title "Screening of diagnostic markers for osteosarcoma" @default.
• W2003869969 cites W149942538 @default.
• W2003869969 cites W1556555576 @default.
• W2003869969 cites W1760933578 @default.
• W2003869969 cites W1813351829 @default.
• W2003869969 cites W1949259756 @default.
• W2003869969 cites W1973760474 @default.
• W2003869969 cites W1998324511 @default.
• W2003869969 cites W2010254599 @default.
• W2003869969 cites W2016484384 @default.
• W2003869969 cites W2025620210 @default.
• W2003869969 cites W2052649367 @default.
• W2003869969 cites W2056244156 @default.
• W2003869969 cites W2057545775 @default.
• W2003869969 cites W2058768410 @default.
• W2003869969 cites W2069756877 @default.
• W2003869969 cites W2075967489 @default.
• W2003869969 cites W2081438440 @default.
• W2003869969 cites W2090807626 @default.
• W2003869969 cites W2092023745 @default.
• W2003869969 cites W2096863518 @default.
• W2003869969 cites W2097707959 @default.
• W2003869969 cites W2115543187 @default.
• W2003869969 cites W2116599555 @default.
• W2003869969 cites W2125673723 @default.
• W2003869969 cites W2144959880 @default.
• W2003869969 cites W2155142785 @default.
• W2003869969 cites W2157374519 @default.
• W2003869969 cites W2159859242 @default.
• W2003869969 cites W2162401840 @default.
• W2003869969 cites W2164614740 @default.
• W2003869969 cites W2171030481 @default.
• W2003869969 cites W2316067769 @default.
• W2003869969 cites W2325060315 @default.
• W2003869969 cites W4246742253 @default.
• W2003869969 doi "https://doi.org/10.3892/mmr.2014.2546" @default.
• W2003869969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25199469" @default.
• W2003869969 hasPublicationYear "2014" @default.
• W2003869969 type Work @default.
• W2003869969 sameAs 2003869969 @default.
• W2003869969 citedByCount "29" @default.
• W2003869969 countsByYear W20038699692016 @default.
• W2003869969 countsByYear W20038699692017 @default.
• W2003869969 countsByYear W20038699692018 @default.
• W2003869969 countsByYear W20038699692019 @default.
• W2003869969 countsByYear W20038699692020 @default.
• W2003869969 countsByYear W20038699692021 @default.
• W2003869969 countsByYear W20038699692022 @default.
• W2003869969 crossrefType "journal-article" @default.
• W2003869969 hasAuthorship W2003869969A5001746337 @default.
• W2003869969 hasAuthorship W2003869969A5012319990 @default.
• W2003869969 hasAuthorship W2003869969A5021384155 @default.
• W2003869969 hasAuthorship W2003869969A5025838203 @default.
• W2003869969 hasAuthorship W2003869969A5059911678 @default.
• W2003869969 hasAuthorship W2003869969A5074339191 @default.
• W2003869969 hasAuthorship W2003869969A5080477696 @default.
• W2003869969 hasAuthorship W2003869969A5084677096 @default.
• W2003869969 hasBestOaLocation W20038699691 @default.
• W2003869969 hasConcept C104317684 @default.
• W2003869969 hasConcept C127561419 @default.
• W2003869969 hasConcept C129527566 @default.
• W2003869969 hasConcept C150194340 @default.
• W2003869969 hasConcept C18431079 @default.
• W2003869969 hasConcept C2777760704 @default.
• W2003869969 hasConcept C2780699576 @default.
• W2003869969 hasConcept C2781018059 @default.
• W2003869969 hasConcept C29537977 @default.
• W2003869969 hasConcept C502942594 @default.
• W2003869969 hasConcept C54355233 @default.
• W2003869969 hasConcept C555283112 @default.
• W2003869969 hasConcept C60644358 @default.
• W2003869969 hasConcept C67082663 @default.
• W2003869969 hasConcept C70721500 @default.
• W2003869969 hasConcept C86803240 @default.
• W2003869969 hasConceptScore W2003869969C104317684 @default.
• W2003869969 hasConceptScore W2003869969C127561419 @default.
• W2003869969 hasConceptScore W2003869969C129527566 @default.
• W2003869969 hasConceptScore W2003869969C150194340 @default.
• W2003869969 hasConceptScore W2003869969C18431079 @default.
• W2003869969 hasConceptScore W2003869969C2777760704 @default.
• W2003869969 hasConceptScore W2003869969C2780699576 @default.
• W2003869969 hasConceptScore W2003869969C2781018059 @default.
• W2003869969 hasConceptScore W2003869969C29537977 @default.
• W2003869969 hasConceptScore W2003869969C502942594 @default.
• W2003869969 hasConceptScore W2003869969C54355233 @default.
• W2003869969 hasConceptScore W2003869969C555283112 @default.

• next