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• W2003875732 abstract "We report the crystal structure solution of the Intracellular Protease Inhibitor (IPI) protein from Bacillus subtilis, which has been reported to be an inhibitor of the intracellular subtilisin Isp1 from the same organism. The structure of IPI is a variant of the all-beta, immunoglobulin (Ig) fold. It is possible that IPI is important for protein-protein interactions, of which inhibition of Isp1 is one. The intracellular nature of ISP is questioned, because an alternative ATG codon in the ipi gene would produce a protein with an N-terminal extension containing a signal peptide. It is possible that alternative initiation exists, producing either an intracellular inhibitor or a secreted form that may be associated with the cell surface. Homologues of the IPI protein from other species are multi-domain proteins, containing signal peptides and domains also associated with the bacterial cell-surface. The cysteine peptidase inhibitors chagasin and amoebiasin also have Ig-like folds, but their topology differs significantly from that of IPI, and they share no recent common ancestor. A model of IPI docked to Isp1 shows similarities to other subtilisin:inhibitor complexes, particularly where the inhibitor interacts with the peptidase active site." @default.
• W2003875732 created "2016-06-24" @default.
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• W2003875732 date "2013-01-01" @default.
• W2003875732 modified "2023-09-23" @default.
• W2003875732 title "The first structure in a family of peptidase inhibitors reveals an unusual Ig-like fold." @default.
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• W2003875732 doi "https://doi.org/10.12688/f1000research.2-154.v1" @default.
• W2003875732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3901451" @default.
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• W2003875732 hasPublicationYear "2013" @default.
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