FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003876192> ?p ?o ?g. }

• W2003876192 endingPage "219" @default.
• W2003876192 startingPage "211" @default.
• W2003876192 abstract "Recurrent small cell lung cancer is a recalcitrant malgnancy. The application of genomic technologies has begun to elucidate the large number of genetic abnormalities in SCLC. Several cell surface receptors are known to be overexpressed by SCLC in clinic specimens and cell in culture including GPCRs such as the bradykinin receptor, the chemokine receptor CXCR4, the vasopression receeptor and the three bomebsin receptors. The glucose transporter GLUT1, the tetraspanin family member PETA/CD151 and the immunoglobulin superfamily member ALCAM/CD166 are also overexpressed by SCLC. NCAM/CD56 is overexpressed by nearly all SCLC and is currently the target for an antibody drug conjugate in Phase II trial. Although SCLC is not considered a RTK driven disease, IGF1R and FGFRs are often overexpressed by SCLC. SCLC abberantly expresses several developmental transcription factors including ASCL1, SOX2, 4, and 11, OCT4, NANOG, PAX5; however, overexpression of MYC may be a driver in SCLC. Like other cancers, SCLC expresses survival factors and uses aerobic glycolysis as a major source of ATP. The drawback of many ponteial targets overexpressed by SCLC is expression of the same proteins by normal tissues. We are slowly learning more about the molecular abnormalities that occur in SCLC; however, therapeutic impact from new findings remains a goal to work toward." @default.
• W2003876192 created "2016-06-24" @default.
• W2003876192 creator A5040137655 @default.
• W2003876192 date "2014-01-01" @default.
• W2003876192 modified "2023-10-16" @default.
• W2003876192 title "Targets in small cell lung cancer" @default.
• W2003876192 cites W1550321605 @default.
• W2003876192 cites W1859579038 @default.
• W2003876192 cites W1965350162 @default.
• W2003876192 cites W1966492254 @default.
• W2003876192 cites W1970222178 @default.
• W2003876192 cites W1971874657 @default.
• W2003876192 cites W1973281664 @default.
• W2003876192 cites W1989422925 @default.
• W2003876192 cites W1992449688 @default.
• W2003876192 cites W1994147646 @default.
• W2003876192 cites W1996883110 @default.
• W2003876192 cites W1997099893 @default.
• W2003876192 cites W1997317582 @default.
• W2003876192 cites W1997762751 @default.
• W2003876192 cites W2001619812 @default.
• W2003876192 cites W2005179811 @default.
• W2003876192 cites W2007333388 @default.
• W2003876192 cites W2012731100 @default.
• W2003876192 cites W2015473806 @default.
• W2003876192 cites W2016722600 @default.
• W2003876192 cites W2018448673 @default.
• W2003876192 cites W2023171799 @default.
• W2003876192 cites W2030025739 @default.
• W2003876192 cites W2032226546 @default.
• W2003876192 cites W2033474014 @default.
• W2003876192 cites W2037548653 @default.
• W2003876192 cites W2038498611 @default.
• W2003876192 cites W2049622129 @default.
• W2003876192 cites W2051598928 @default.
• W2003876192 cites W2052176791 @default.
• W2003876192 cites W2052339653 @default.
• W2003876192 cites W2054121852 @default.
• W2003876192 cites W2061828956 @default.
• W2003876192 cites W2064608769 @default.
• W2003876192 cites W2065946901 @default.
• W2003876192 cites W2071133953 @default.
• W2003876192 cites W2072035809 @default.
• W2003876192 cites W2073031201 @default.
• W2003876192 cites W2081921364 @default.
• W2003876192 cites W2091347388 @default.
• W2003876192 cites W2092335849 @default.
• W2003876192 cites W2092880963 @default.
• W2003876192 cites W2093176773 @default.
• W2003876192 cites W2097977881 @default.
• W2003876192 cites W2098161852 @default.
• W2003876192 cites W2098672118 @default.
• W2003876192 cites W2098696935 @default.
• W2003876192 cites W2106465830 @default.
• W2003876192 cites W2107975811 @default.
• W2003876192 cites W2113472355 @default.
• W2003876192 cites W2114076439 @default.
• W2003876192 cites W2115346329 @default.
• W2003876192 cites W2116798922 @default.
• W2003876192 cites W2119595387 @default.
• W2003876192 cites W2122241065 @default.
• W2003876192 cites W2122816217 @default.
• W2003876192 cites W2125871683 @default.
• W2003876192 cites W2126701902 @default.
• W2003876192 cites W2126709547 @default.
• W2003876192 cites W2144233009 @default.
• W2003876192 cites W2147590200 @default.
• W2003876192 cites W2153052764 @default.
• W2003876192 cites W2153216820 @default.
• W2003876192 cites W2159194061 @default.
• W2003876192 cites W2161467139 @default.
• W2003876192 cites W2161577298 @default.
• W2003876192 cites W2164741305 @default.
• W2003876192 cites W2165471177 @default.
• W2003876192 cites W2167068682 @default.
• W2003876192 cites W2167869412 @default.
• W2003876192 cites W2184873303 @default.
• W2003876192 cites W2329191693 @default.
• W2003876192 doi "https://doi.org/10.1016/j.bcp.2013.09.014" @default.
• W2003876192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24091017" @default.
• W2003876192 hasPublicationYear "2014" @default.
• W2003876192 type Work @default.
• W2003876192 sameAs 2003876192 @default.
• W2003876192 citedByCount "61" @default.
• W2003876192 countsByYear W20038761922014 @default.
• W2003876192 countsByYear W20038761922015 @default.
• W2003876192 countsByYear W20038761922016 @default.
• W2003876192 countsByYear W20038761922017 @default.
• W2003876192 countsByYear W20038761922018 @default.
• W2003876192 countsByYear W20038761922019 @default.
• W2003876192 countsByYear W20038761922020 @default.
• W2003876192 countsByYear W20038761922021 @default.
• W2003876192 countsByYear W20038761922022 @default.
• W2003876192 countsByYear W20038761922023 @default.
• W2003876192 crossrefType "journal-article" @default.
• W2003876192 hasAuthorship W2003876192A5040137655 @default.
• W2003876192 hasBestOaLocation W20038761921 @default.
• W2003876192 hasConcept C104317684 @default.

• next