FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003876656> ?p ?o ?g. }

• W2003876656 endingPage "e1004118" @default.
• W2003876656 startingPage "e1004118" @default.
• W2003876656 abstract "Since platelet intracellular calcium mobilization [Ca(t)]i controls granule release, cyclooxygenase-1 and integrin activation, and phosphatidylserine exposure, blood clotting simulations require prediction of platelet [Ca(t)]i in response to combinatorial agonists. Pairwise Agonist Scanning (PAS) deployed all single and pairwise combinations of six agonists (ADP, convulxin, thrombin, U46619, iloprost and GSNO used at 0.1, 1, and 10xEC50; 154 conditions including a null condition) to stimulate platelet P2Y1/P2Y12 GPVI, PAR1/PAR4, TP, IP receptors, and guanylate cyclase, respectively, in Factor Xa-inhibited (250 nM apixaban), diluted platelet rich plasma that had been loaded with the calcium dye Fluo-4 NW. PAS of 10 healthy donors provided [Ca(t)]i data for training 10 neural networks (NN, 2-layer/12-nodes) per donor. Trinary stimulations were then conducted at all 0.1x and 1xEC50 doses (160 conditions) as was a sampling of 45 higher ordered combinations (four to six agonists). The NN-ensemble average was a calcium calculator that accurately predicted [Ca (t)]i beyond the single and binary training set for trinary stimulations (R = 0.924). The 160 trinary synergy scores, a normalized metric of signaling crosstalk, were also well predicted (R = 0.850) as were the calcium dynamics (R = 0.871) and high-dimensional synergy scores (R = 0.695) for the 45 higher ordered conditions. The calculator even predicted sequential addition experiments (n = 54 conditions, R = 0.921). NN-ensemble is a fast calcium calculator, ideal for multiscale clotting simulations that include spatiotemporal concentrations of ADP, collagen, thrombin, thromboxane, prostacyclin, and nitric oxide." @default.
• W2003876656 created "2016-06-24" @default.
• W2003876656 creator A5022452368 @default.
• W2003876656 creator A5065179734 @default.
• W2003876656 date "2015-02-27" @default.
• W2003876656 modified "2023-10-02" @default.
• W2003876656 title "A Human Platelet Calcium Calculator Trained by Pairwise Agonist Scanning" @default.
• W2003876656 cites W131722789 @default.
• W2003876656 cites W1519061284 @default.
• W2003876656 cites W1578980777 @default.
• W2003876656 cites W1604015258 @default.
• W2003876656 cites W1654419898 @default.
• W2003876656 cites W1978605633 @default.
• W2003876656 cites W1986162817 @default.
• W2003876656 cites W1989149221 @default.
• W2003876656 cites W1993695315 @default.
• W2003876656 cites W2005515164 @default.
• W2003876656 cites W2018419722 @default.
• W2003876656 cites W2047137672 @default.
• W2003876656 cites W2061082730 @default.
• W2003876656 cites W2061119986 @default.
• W2003876656 cites W2073966706 @default.
• W2003876656 cites W2078207049 @default.
• W2003876656 cites W2081246578 @default.
• W2003876656 cites W2083203405 @default.
• W2003876656 cites W2101613467 @default.
• W2003876656 cites W2103746902 @default.
• W2003876656 cites W2107361996 @default.
• W2003876656 cites W2115629999 @default.
• W2003876656 cites W2132244872 @default.
• W2003876656 cites W2133370274 @default.
• W2003876656 cites W2141445903 @default.
• W2003876656 cites W2150757437 @default.
• W2003876656 cites W2151862456 @default.
• W2003876656 cites W2154789382 @default.
• W2003876656 cites W2155892324 @default.
• W2003876656 cites W2171278791 @default.
• W2003876656 cites W2171752105 @default.
• W2003876656 cites W2911964244 @default.
• W2003876656 doi "https://doi.org/10.1371/journal.pcbi.1004118" @default.
• W2003876656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4344206" @default.
• W2003876656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25723389" @default.
• W2003876656 hasPublicationYear "2015" @default.
• W2003876656 type Work @default.
• W2003876656 sameAs 2003876656 @default.
• W2003876656 citedByCount "19" @default.
• W2003876656 countsByYear W20038766562016 @default.
• W2003876656 countsByYear W20038766562017 @default.
• W2003876656 countsByYear W20038766562018 @default.
• W2003876656 countsByYear W20038766562019 @default.
• W2003876656 countsByYear W20038766562020 @default.
• W2003876656 countsByYear W20038766562022 @default.
• W2003876656 countsByYear W20038766562023 @default.
• W2003876656 crossrefType "journal-article" @default.
• W2003876656 hasAuthorship W2003876656A5022452368 @default.
• W2003876656 hasAuthorship W2003876656A5065179734 @default.
• W2003876656 hasBestOaLocation W20038766561 @default.
• W2003876656 hasConcept C12554922 @default.
• W2003876656 hasConcept C126322002 @default.
• W2003876656 hasConcept C170493617 @default.
• W2003876656 hasConcept C178790620 @default.
• W2003876656 hasConcept C185592680 @default.
• W2003876656 hasConcept C2778938600 @default.
• W2003876656 hasConcept C3018697912 @default.
• W2003876656 hasConcept C519063684 @default.
• W2003876656 hasConcept C55493867 @default.
• W2003876656 hasConcept C71924100 @default.
• W2003876656 hasConcept C86803240 @default.
• W2003876656 hasConcept C89560881 @default.
• W2003876656 hasConcept C98274493 @default.
• W2003876656 hasConceptScore W2003876656C12554922 @default.
• W2003876656 hasConceptScore W2003876656C126322002 @default.
• W2003876656 hasConceptScore W2003876656C170493617 @default.
• W2003876656 hasConceptScore W2003876656C178790620 @default.
• W2003876656 hasConceptScore W2003876656C185592680 @default.
• W2003876656 hasConceptScore W2003876656C2778938600 @default.
• W2003876656 hasConceptScore W2003876656C3018697912 @default.
• W2003876656 hasConceptScore W2003876656C519063684 @default.
• W2003876656 hasConceptScore W2003876656C55493867 @default.
• W2003876656 hasConceptScore W2003876656C71924100 @default.
• W2003876656 hasConceptScore W2003876656C86803240 @default.
• W2003876656 hasConceptScore W2003876656C89560881 @default.
• W2003876656 hasConceptScore W2003876656C98274493 @default.
• W2003876656 hasIssue "2" @default.
• W2003876656 hasLocation W20038766561 @default.
• W2003876656 hasLocation W20038766562 @default.
• W2003876656 hasLocation W20038766563 @default.
• W2003876656 hasOpenAccess W2003876656 @default.
• W2003876656 hasPrimaryLocation W20038766561 @default.
• W2003876656 hasRelatedWork W1971972263 @default.
• W2003876656 hasRelatedWork W1999185415 @default.
• W2003876656 hasRelatedWork W2085718822 @default.
• W2003876656 hasRelatedWork W2092770098 @default.
• W2003876656 hasRelatedWork W2101566329 @default.
• W2003876656 hasRelatedWork W2163959335 @default.
• W2003876656 hasRelatedWork W2382868805 @default.
• W2003876656 hasRelatedWork W2401678231 @default.
• W2003876656 hasRelatedWork W4248554551 @default.

• next