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- W2003882305 abstract "A hypothesis is presented to account for the puzzling nonspecificity toward the A ring and for slow immune response to oestrogen-4(2)-(4'-carboxyphenylazo)- or 4(2)-azoprotein conjugates which has been described in the literature and was also found in our laboratory. The phenomenon is associated with the presence of tautomeric forms of haptens in the conjugates. High cross-reactivity of antisera to these haptens with C-3 derivatives of the oestrogens and with substances structurally related to their quinonoid forms is explained by the existence of the internal hydrogen bond in o-hydroxyazo-conjugated steroids and by conversion of these haptens to quinonoid structures. The influence of the carrier protein and of the mode of immunization on the proportions of the two tautomeric forms in the conjugates is discussed." @default.
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- W2003882305 date "1980-06-01" @default.
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- W2003882305 title "Specificity of antisera to oestrogen-azo-protein conjugates: The influence of tautomerism and carrier proteins" @default.
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- W2003882305 doi "https://doi.org/10.1016/0022-4731(80)90035-7" @default.
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