FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003883380> ?p ?o ?g. }

• W2003883380 endingPage "2324" @default.
• W2003883380 startingPage "2315" @default.
• W2003883380 abstract "By integrating gene profiling and immunohistochemical data with functional experiments in cell lines in this study we show for the first time that doublecortin (DCX) domain containing 2 (DCDC2), a protein belonging to the DCX family and involved in neuronal cell migration, is aberrantly expressed in prostate tumors whereas absent in normal prostate. Furthermore, in patients treated with radical prostatectomy, high levels of DCDC2 RNA were significantly associated with increased biochemical relapse (LogRank Mantel-Cox=0.012). Mechanistically, we found that the ETS transcription factor ESE3/EHF, which is expressed in normal prostate and frequently lost in prostate tumors, maintained DCDC2 repressed by binding to a novel identified ETS binding site in the gene promoter. Consistently, in prostate tumors and in cellular models of gain and loss of ESE3/EHF, the expression of DCDC2 and ESE3/EHF were inversely correlated. In prostate cancer cells, DCDC2 colocalized with microtubules and promoted cell migration and resistance to the microtubule-targeting drug taxol. Collectively, this study establishes DCDC2 as a novel ESE3/EHF oncogenic target in prostate cancer. These findings may be relevant for the clinical management of prostate cancer as DCDC2 may signal tumors more prone to relapse and resistant to taxol treatment." @default.
• W2003883380 created "2016-06-24" @default.
• W2003883380 creator A5003180276 @default.
• W2003883380 creator A5006430726 @default.
• W2003883380 creator A5007812683 @default.
• W2003883380 creator A5020359831 @default.
• W2003883380 creator A5053317832 @default.
• W2003883380 creator A5070168468 @default.
• W2003883380 creator A5074144174 @default.
• W2003883380 creator A5074276689 @default.
• W2003883380 creator A5080453671 @default.
• W2003883380 creator A5080617518 @default.
• W2003883380 creator A5086203994 @default.
• W2003883380 creator A5087459166 @default.
• W2003883380 date "2012-06-25" @default.
• W2003883380 modified "2023-10-17" @default.
• W2003883380 title "Aberrant expression of the neuronal-specific protein DCDC2 promotes malignant phenotypes and is associated with prostate cancer progression" @default.
• W2003883380 cites W1591187753 @default.
• W2003883380 cites W1940044602 @default.
• W2003883380 cites W1963749564 @default.
• W2003883380 cites W1970343267 @default.
• W2003883380 cites W1976677295 @default.
• W2003883380 cites W1982009630 @default.
• W2003883380 cites W1982538300 @default.
• W2003883380 cites W1988073586 @default.
• W2003883380 cites W2009080513 @default.
• W2003883380 cites W2021741261 @default.
• W2003883380 cites W2024490679 @default.
• W2003883380 cites W2027216886 @default.
• W2003883380 cites W2031266198 @default.
• W2003883380 cites W2033951671 @default.
• W2003883380 cites W2037834300 @default.
• W2003883380 cites W2040941510 @default.
• W2003883380 cites W2049205984 @default.
• W2003883380 cites W2049908093 @default.
• W2003883380 cites W2062393124 @default.
• W2003883380 cites W2063377436 @default.
• W2003883380 cites W2063511140 @default.
• W2003883380 cites W2068745192 @default.
• W2003883380 cites W2082462837 @default.
• W2003883380 cites W2087207490 @default.
• W2003883380 cites W2087321474 @default.
• W2003883380 cites W2093855538 @default.
• W2003883380 cites W2105606962 @default.
• W2003883380 cites W2105632506 @default.
• W2003883380 cites W2113602122 @default.
• W2003883380 cites W2121158863 @default.
• W2003883380 cites W2127841477 @default.
• W2003883380 cites W2148233030 @default.
• W2003883380 cites W2156104877 @default.
• W2003883380 cites W4211195653 @default.
• W2003883380 doi "https://doi.org/10.1038/onc.2012.245" @default.
• W2003883380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22733135" @default.
• W2003883380 hasPublicationYear "2012" @default.
• W2003883380 type Work @default.
• W2003883380 sameAs 2003883380 @default.
• W2003883380 citedByCount "21" @default.
• W2003883380 countsByYear W20038833802013 @default.
• W2003883380 countsByYear W20038833802015 @default.
• W2003883380 countsByYear W20038833802016 @default.
• W2003883380 countsByYear W20038833802017 @default.
• W2003883380 countsByYear W20038833802018 @default.
• W2003883380 countsByYear W20038833802019 @default.
• W2003883380 countsByYear W20038833802020 @default.
• W2003883380 countsByYear W20038833802021 @default.
• W2003883380 countsByYear W20038833802022 @default.
• W2003883380 countsByYear W20038833802023 @default.
• W2003883380 crossrefType "journal-article" @default.
• W2003883380 hasAuthorship W2003883380A5003180276 @default.
• W2003883380 hasAuthorship W2003883380A5006430726 @default.
• W2003883380 hasAuthorship W2003883380A5007812683 @default.
• W2003883380 hasAuthorship W2003883380A5020359831 @default.
• W2003883380 hasAuthorship W2003883380A5053317832 @default.
• W2003883380 hasAuthorship W2003883380A5070168468 @default.
• W2003883380 hasAuthorship W2003883380A5074144174 @default.
• W2003883380 hasAuthorship W2003883380A5074276689 @default.
• W2003883380 hasAuthorship W2003883380A5080453671 @default.
• W2003883380 hasAuthorship W2003883380A5080617518 @default.
• W2003883380 hasAuthorship W2003883380A5086203994 @default.
• W2003883380 hasAuthorship W2003883380A5087459166 @default.
• W2003883380 hasBestOaLocation W20038833801 @default.
• W2003883380 hasConcept C104317684 @default.
• W2003883380 hasConcept C121608353 @default.
• W2003883380 hasConcept C134018914 @default.
• W2003883380 hasConcept C145059251 @default.
• W2003883380 hasConcept C2776235491 @default.
• W2003883380 hasConcept C2776464000 @default.
• W2003883380 hasConcept C2780192828 @default.
• W2003883380 hasConcept C2781461022 @default.
• W2003883380 hasConcept C502942594 @default.
• W2003883380 hasConcept C529278444 @default.
• W2003883380 hasConcept C54355233 @default.
• W2003883380 hasConcept C86803240 @default.
• W2003883380 hasConceptScore W2003883380C104317684 @default.
• W2003883380 hasConceptScore W2003883380C121608353 @default.
• W2003883380 hasConceptScore W2003883380C134018914 @default.
• W2003883380 hasConceptScore W2003883380C145059251 @default.
• W2003883380 hasConceptScore W2003883380C2776235491 @default.

• next