Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003886367> ?p ?o ?g. }
- W2003886367 endingPage "531" @default.
- W2003886367 startingPage "524" @default.
- W2003886367 abstract "Solution conformations of three series of model peptides, homochiral Ac-Pro-L-Xaa-NHCH3 and heterochiral Ac-Pro-D-Xaa-NHCH3 (Xaa = Val, Phe, Leu, Abu, Ala) as well as alpha,beta-unsaturated Ac-Pro-delta Xaa-NHCH3 [delta Xaa = delta Val, (Z)-delta Phe, (Z)-delta Leu, (Z)-delta Abu] were investigated in CDCl3 and CH2Cl2 by 1H-, 13C-NMR, and FTIR spectroscopy. NH stretching absorption spectra, solvent shifts delta delta for NH (Xaa) and NHCH3 on going from CDCl3 to (CD3)2SO, diagnostic interresidue proton NOEs, and trans-cis isomer ratios were examined. These studies performed showed the essential difference in conformational propensities between homochiral peptides (L-Xaa) on the one hand and heterochiral (D-Xaa) and alpha,beta-dehydropeptides (delta Xaa) on the other. Former compounds are conformationally flexible with an inverse gamma-bend, a beta-turn, and open forms in an equilibrium depending on the nature of the Xaa side chain. Conformational preferences of heterochiral and alpha,beta-dehydropeptides are very similar, with the type-II beta-turn as the dominating structure. There is no apparent correlation between conformational properties and the nature of the Xaa side chain within the two groups. The beta-turn formation propensity seems to be somewhat greater in alpha,beta-unsaturated than in heterochiral peptides, but an estimation of beta-folded conformers is risky." @default.
- W2003886367 created "2016-06-24" @default.
- W2003886367 creator A5001241149 @default.
- W2003886367 creator A5003460809 @default.
- W2003886367 creator A5053178308 @default.
- W2003886367 date "2009-01-12" @default.
- W2003886367 modified "2023-10-10" @default.
- W2003886367 title "Conformational investigation of αβ-dehydropeptides" @default.
- W2003886367 cites W1510963724 @default.
- W2003886367 cites W1544623810 @default.
- W2003886367 cites W1586022877 @default.
- W2003886367 cites W1966682957 @default.
- W2003886367 cites W1973034892 @default.
- W2003886367 cites W1978173701 @default.
- W2003886367 cites W1985131473 @default.
- W2003886367 cites W1987984233 @default.
- W2003886367 cites W1988835590 @default.
- W2003886367 cites W1992562420 @default.
- W2003886367 cites W2001378596 @default.
- W2003886367 cites W2001977650 @default.
- W2003886367 cites W2004900056 @default.
- W2003886367 cites W2007935246 @default.
- W2003886367 cites W2008450056 @default.
- W2003886367 cites W2009709411 @default.
- W2003886367 cites W2013043801 @default.
- W2003886367 cites W2015824215 @default.
- W2003886367 cites W2019391108 @default.
- W2003886367 cites W2027991801 @default.
- W2003886367 cites W2033226266 @default.
- W2003886367 cites W2034137054 @default.
- W2003886367 cites W2043278611 @default.
- W2003886367 cites W2052659665 @default.
- W2003886367 cites W2057634910 @default.
- W2003886367 cites W2057987904 @default.
- W2003886367 cites W2061005076 @default.
- W2003886367 cites W2061449889 @default.
- W2003886367 cites W2063969111 @default.
- W2003886367 cites W2068640833 @default.
- W2003886367 cites W2074531881 @default.
- W2003886367 cites W2075321603 @default.
- W2003886367 cites W2079500765 @default.
- W2003886367 cites W2080089001 @default.
- W2003886367 cites W2096075706 @default.
- W2003886367 cites W2131513351 @default.
- W2003886367 cites W2152936660 @default.
- W2003886367 cites W2484084472 @default.
- W2003886367 cites W2484502677 @default.
- W2003886367 cites W2622142360 @default.
- W2003886367 cites W2623699088 @default.
- W2003886367 cites W2950331531 @default.
- W2003886367 cites W295484251 @default.
- W2003886367 cites W4323284750 @default.
- W2003886367 cites W4323285570 @default.
- W2003886367 cites W4323285571 @default.
- W2003886367 doi "https://doi.org/10.1111/j.1399-3011.1992.tb00436.x" @default.
- W2003886367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1286936" @default.
- W2003886367 hasPublicationYear "2009" @default.
- W2003886367 type Work @default.
- W2003886367 sameAs 2003886367 @default.
- W2003886367 citedByCount "33" @default.
- W2003886367 countsByYear W20038863672013 @default.
- W2003886367 countsByYear W20038863672015 @default.
- W2003886367 countsByYear W20038863672017 @default.
- W2003886367 countsByYear W20038863672019 @default.
- W2003886367 countsByYear W20038863672021 @default.
- W2003886367 crossrefType "journal-article" @default.
- W2003886367 hasAuthorship W2003886367A5001241149 @default.
- W2003886367 hasAuthorship W2003886367A5003460809 @default.
- W2003886367 hasAuthorship W2003886367A5053178308 @default.
- W2003886367 hasConcept C178790620 @default.
- W2003886367 hasConcept C185592680 @default.
- W2003886367 hasConcept C18705241 @default.
- W2003886367 hasConcept C199360897 @default.
- W2003886367 hasConcept C204921945 @default.
- W2003886367 hasConcept C2776174256 @default.
- W2003886367 hasConcept C2780471494 @default.
- W2003886367 hasConcept C32909587 @default.
- W2003886367 hasConcept C41008148 @default.
- W2003886367 hasConcept C521977710 @default.
- W2003886367 hasConcept C55493867 @default.
- W2003886367 hasConcept C71240020 @default.
- W2003886367 hasConcept C8010536 @default.
- W2003886367 hasConcept C85641259 @default.
- W2003886367 hasConceptScore W2003886367C178790620 @default.
- W2003886367 hasConceptScore W2003886367C185592680 @default.
- W2003886367 hasConceptScore W2003886367C18705241 @default.
- W2003886367 hasConceptScore W2003886367C199360897 @default.
- W2003886367 hasConceptScore W2003886367C204921945 @default.
- W2003886367 hasConceptScore W2003886367C2776174256 @default.
- W2003886367 hasConceptScore W2003886367C2780471494 @default.
- W2003886367 hasConceptScore W2003886367C32909587 @default.
- W2003886367 hasConceptScore W2003886367C41008148 @default.
- W2003886367 hasConceptScore W2003886367C521977710 @default.
- W2003886367 hasConceptScore W2003886367C55493867 @default.
- W2003886367 hasConceptScore W2003886367C71240020 @default.
- W2003886367 hasConceptScore W2003886367C8010536 @default.
- W2003886367 hasConceptScore W2003886367C85641259 @default.
- W2003886367 hasIssue "6" @default.