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• W2003886430 abstract "Context: Fexofenadine hydrochloride (FXD) is a slightly soluble, bitter-tasting, drug having an oral bioavailability of 35%. The maximum plasma concentration is reached 2.6 h (Tmax) post-dose.Objective: Developing taste-masked FXD orodispersible tablets (ODTs) to increase extent of drug absorption and reduce Tmax.Methods: Taste masking was achieved via solid dispersion (SD) with chitosan (CS) or sodium alginate (ALG). Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffraction were performed to identify physicochemical interactions and FXD crystallinity. Taste-masked FXD-ODTs were developed via addition of superdisintegrants (croscarmellose sodium or sodium starch glycolate, 5% and 10%, w/w) or sublimable agents (camphor, menthol or thymol; 10% and 20%, w/w) to FXD-SDs. ODTs were evaluated for weight variation, drug-content, friability, wetting, disintegration and drug release. Camphor-based (20%, w/w) FXD-ODT (F12) was optimized (F23) by incorporation of a more hydrophilic lubricant (Pruv®), visualized via scanning electron microscopy and evaluated for FXD pharmacokinetics in healthy volunteers relative to Allegra® tablets.Results: Based on gustatory sensation test, FXD–CS (1:1) and FXD–ALG (1:0.5) SDs were selected. Taste-masked FXD-ODTs had appropriate physicochemical properties. Drug release profiles of F23 and the phenylalanine-containing Allegra® ODT were similar (f2 = 96). Pores were observed following camphor sublimation. The pharmacokinetic studies proved F23 ability to increase extent of FXD absorption and reduce Tmax." @default.
• W2003886430 created "2016-06-24" @default.
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• W2003886430 date "2014-02-03" @default.
• W2003886430 modified "2023-09-26" @default.
• W2003886430 title "Phenylalanine-free taste-masked orodispersible tablets of fexofenadine hydrochloride: development,<i>in vitro</i>evaluation and<i>in vivo</i>estimation of the drug pharmacokinetics in healthy human volunteers" @default.
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• W2003886430 doi "https://doi.org/10.3109/10837450.2014.882942" @default.
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