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- W2003899223 abstract "There is a growing interest in plant polyphenols (including flavanols) that exhibit pleiotropic biological activities such as antiinflammatory, antioxidant, and anticancer effects. Here, we report for the first time the inhibition of MDA-MB-231 breast cancer cell viability and invasiveness by an evening primrose flavanol preparation (EPFP). We observed a decrease in MDA-MB-231 viability of 50% vs. a control after 72 h of incubation with EPFP at a concentration of 58 μM gallic acid equivalents (GAE) and an inhibition of their invasiveness of 65% vs. a control at 75 μM GAE after 48 h of incubation. EPFP caused a 10-fold reduction in matrix metalloproteinase-9 (MMP-9) activity at 100 μM GAE. Furthermore, through modulation of mRNA expression, EPFP reduced the expression levels of the following proteins: antiapoptotic Bcl-2, angiogenic vascular endothelial growth factor (VEGF), and 2 transcription factors (c-Jun, c-Fos). Moreover, analysis by flow cytometry revealed that EPFP induced apoptosis in MDA-MB-231 cells. In conclusion, our data shows that EPFP inhibits cell viability by increasing apoptosis and decreases cell invasiveness by decreasing angiogenesis." @default.
- W2003899223 created "2016-06-24" @default.
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- W2003899223 date "2013-11-01" @default.
- W2003899223 modified "2023-09-27" @default.
- W2003899223 title "Procyanidins from Evening Primrose (<i>Oenothera paradoxa</i>) Defatted Seeds Inhibit Invasiveness of Breast Cancer Cells and Modulate the Expression of Selected Genes Involved in Angiogenesis, Metastasis, and Apoptosis" @default.
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- W2003899223 doi "https://doi.org/10.1080/01635581.2013.830314" @default.
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