Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003902215> ?p ?o ?g. }
- W2003902215 endingPage "e54387" @default.
- W2003902215 startingPage "e54387" @default.
- W2003902215 abstract "Opportunistic fungal pathogens may cause an array of superficial infections or serious invasive infections, especially in immunocompromised patients. Cryptococcus neoformans is a pathogen causing cryptococcosis in HIV/AIDS patients, but treatment is limited due to the relative lack of potent antifungal agents. Photodynamic inactivation (PDI) uses the combination of non-toxic dyes called photosensitizers and harmless visible light, which produces singlet oxygen and other reactive oxygen species that produce cell inactivation and death. We report the use of five structurally unrelated photosensitizers (methylene blue, Rose Bengal, selenium derivative of a Nile blue dye, a cationic fullerene and a conjugate between poly-L-lysine and chlorin(e6)) combined with appropriate wavelengths of light to inactivate C. neoformans. Mutants lacking capsule and laccase, and culture conditions that favoured melanin production were used to probe the mechanisms of PDI and the effect of virulence factors. The presence of cell wall, laccase and melanin tended to protect against PDI, but the choice of the appropriate photosensitizers and dosimetry was able to overcome this resistance." @default.
- W2003902215 created "2016-06-24" @default.
- W2003902215 creator A5001374433 @default.
- W2003902215 creator A5011903299 @default.
- W2003902215 creator A5013703533 @default.
- W2003902215 creator A5019738419 @default.
- W2003902215 creator A5024297883 @default.
- W2003902215 creator A5039014202 @default.
- W2003902215 creator A5049808068 @default.
- W2003902215 creator A5067107112 @default.
- W2003902215 creator A5078631010 @default.
- W2003902215 date "2013-01-18" @default.
- W2003902215 modified "2023-09-23" @default.
- W2003902215 title "Effect of Virulence Factors on the Photodynamic Inactivation of Cryptococcus neoformans" @default.
- W2003902215 cites W1499601028 @default.
- W2003902215 cites W1504567645 @default.
- W2003902215 cites W1586957091 @default.
- W2003902215 cites W1596848781 @default.
- W2003902215 cites W1848489979 @default.
- W2003902215 cites W1862362509 @default.
- W2003902215 cites W1963735411 @default.
- W2003902215 cites W1966135389 @default.
- W2003902215 cites W1971292240 @default.
- W2003902215 cites W1972998785 @default.
- W2003902215 cites W1975320008 @default.
- W2003902215 cites W1986172847 @default.
- W2003902215 cites W1987745901 @default.
- W2003902215 cites W1999941292 @default.
- W2003902215 cites W2006156314 @default.
- W2003902215 cites W2009481357 @default.
- W2003902215 cites W2019098068 @default.
- W2003902215 cites W2026889493 @default.
- W2003902215 cites W2033438418 @default.
- W2003902215 cites W2037184390 @default.
- W2003902215 cites W2039976914 @default.
- W2003902215 cites W2043173006 @default.
- W2003902215 cites W2043933728 @default.
- W2003902215 cites W2055593282 @default.
- W2003902215 cites W2060900395 @default.
- W2003902215 cites W2062406170 @default.
- W2003902215 cites W2063124840 @default.
- W2003902215 cites W2064843864 @default.
- W2003902215 cites W2068643257 @default.
- W2003902215 cites W2071501438 @default.
- W2003902215 cites W2078907613 @default.
- W2003902215 cites W2078980546 @default.
- W2003902215 cites W2083968901 @default.
- W2003902215 cites W2087198999 @default.
- W2003902215 cites W2094848014 @default.
- W2003902215 cites W2098169836 @default.
- W2003902215 cites W2101141539 @default.
- W2003902215 cites W2104014765 @default.
- W2003902215 cites W2107124262 @default.
- W2003902215 cites W2109687620 @default.
- W2003902215 cites W2112148102 @default.
- W2003902215 cites W2115286984 @default.
- W2003902215 cites W2115427608 @default.
- W2003902215 cites W2116435169 @default.
- W2003902215 cites W2124117726 @default.
- W2003902215 cites W2142161768 @default.
- W2003902215 cites W2142641565 @default.
- W2003902215 cites W2143121658 @default.
- W2003902215 cites W2144566133 @default.
- W2003902215 cites W2144630525 @default.
- W2003902215 cites W2146948622 @default.
- W2003902215 cites W2150296897 @default.
- W2003902215 cites W2151077290 @default.
- W2003902215 cites W2155044817 @default.
- W2003902215 cites W2155995139 @default.
- W2003902215 cites W2157375389 @default.
- W2003902215 cites W2158005927 @default.
- W2003902215 cites W2158040399 @default.
- W2003902215 cites W2161143301 @default.
- W2003902215 cites W2165821599 @default.
- W2003902215 cites W2171349847 @default.
- W2003902215 cites W2171485788 @default.
- W2003902215 cites W2171932911 @default.
- W2003902215 cites W4210875411 @default.
- W2003902215 cites W4246512332 @default.
- W2003902215 cites W51514869 @default.
- W2003902215 doi "https://doi.org/10.1371/journal.pone.0054387" @default.
- W2003902215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3548784" @default.
- W2003902215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23349872" @default.
- W2003902215 hasPublicationYear "2013" @default.
- W2003902215 type Work @default.
- W2003902215 sameAs 2003902215 @default.
- W2003902215 citedByCount "29" @default.
- W2003902215 countsByYear W20039022152015 @default.
- W2003902215 countsByYear W20039022152016 @default.
- W2003902215 countsByYear W20039022152017 @default.
- W2003902215 countsByYear W20039022152018 @default.
- W2003902215 countsByYear W20039022152019 @default.
- W2003902215 countsByYear W20039022152020 @default.
- W2003902215 countsByYear W20039022152021 @default.
- W2003902215 countsByYear W20039022152022 @default.
- W2003902215 countsByYear W20039022152023 @default.
- W2003902215 crossrefType "journal-article" @default.
- W2003902215 hasAuthorship W2003902215A5001374433 @default.