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- W2003906008 abstract "Characterization and quantitative analysis of oxidation plays an important role in biopharmaceutical development. This study demonstrates an approach to the assessment of susceptible to oxidation methionine residues in monoclonal antibodies and recombinant proteins. A method for the determination of oxidation levels by peptide mapping with mass spectrometric (MS) detection is described and its advantages compared to the UV detection are presented. Good linearity and reproducibility for determination of oxidation with MS detection are demonstrated (R2 > 0.99; RSDs of 4-9%). Aspects of method transfer to quality control group (QC) are discussed. As well, a quick and easy flow injection/MS method is proposed to substitute for peptide map analysis. Peptide coverage, linearity, reproducibility, robustness, sensitivity and quantitative oxidation results are compared for the flow injection/MS and LC/MS approaches." @default.
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- W2003906008 date "2006-08-01" @default.
- W2003906008 modified "2023-10-13" @default.
- W2003906008 title "Determination of protein oxidation by mass spectrometry and method transfer to quality control" @default.
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- W2003906008 doi "https://doi.org/10.1016/j.chroma.2006.04.046" @default.
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