Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003917068> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2003917068 abstract "1 MK 421 and its lysine analogue are two new inhibitors of angiotensin converting enzyme. Ten mg of both compounds were each given p.o. to 12 normotensive volunteers to determine their effect on the various components of the renin angiotensin aldosterone system. 2 Plasma converting enzyme activity decreased to very low levels within 3 to 4 h to recover only slowly over the next 72 h. Plasma angiotensin II and aldosterone also fell but returned to baseline within 24 h, whereas plasma renin activity rose reflecting the low angiotensin II levels. 3 There was a close correlation between both angiotensin II and aldosterone levels and the logarithm of plasma converting enzyme activity demonstrating that angiotensin II and aldosterone fell only when converting enzyme activity was reduced to very low levels. 4 Mean hourly urinary sodium excretion increased markedly 6 to 10 h post-drug, while blood pressure decreased slightly. Both drugs were well tolerated. 5 Thus 10 mg of MK 421 or its lysine analogue given orally are effective and long acting angiotensin converting enzyme inhibitors." @default.
- W2003917068 created "2016-06-24" @default.
- W2003917068 creator A5001428503 @default.
- W2003917068 creator A5006015206 @default.
- W2003917068 creator A5058234638 @default.
- W2003917068 creator A5060042484 @default.
- W2003917068 creator A5067780716 @default.
- W2003917068 creator A5068813714 @default.
- W2003917068 creator A5072851099 @default.
- W2003917068 creator A5076320186 @default.
- W2003917068 date "2004-12-01" @default.
- W2003917068 modified "2023-10-15" @default.
- W2003917068 title "Effect of a new angiotensin converting enzyme inhibitor MK 421 and its lysine analogue on the components of the renin system in healthy subjects" @default.
- W2003917068 cites W1986897111 @default.
- W2003917068 cites W2060153114 @default.
- W2003917068 cites W2081093605 @default.
- W2003917068 cites W2083720135 @default.
- W2003917068 cites W2090095827 @default.
- W2003917068 cites W2166029232 @default.
- W2003917068 cites W2172225485 @default.
- W2003917068 cites W2316814104 @default.
- W2003917068 cites W2322461415 @default.
- W2003917068 cites W2325797916 @default.
- W2003917068 cites W2395720993 @default.
- W2003917068 doi "https://doi.org/10.1111/j.1365-2125.2004.02294.x" @default.
- W2003917068 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1884670" @default.
- W2003917068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6268131" @default.
- W2003917068 hasPublicationYear "2004" @default.
- W2003917068 type Work @default.
- W2003917068 sameAs 2003917068 @default.
- W2003917068 citedByCount "70" @default.
- W2003917068 countsByYear W20039170682014 @default.
- W2003917068 countsByYear W20039170682015 @default.
- W2003917068 countsByYear W20039170682016 @default.
- W2003917068 countsByYear W20039170682020 @default.
- W2003917068 countsByYear W20039170682022 @default.
- W2003917068 crossrefType "journal-article" @default.
- W2003917068 hasAuthorship W2003917068A5001428503 @default.
- W2003917068 hasAuthorship W2003917068A5006015206 @default.
- W2003917068 hasAuthorship W2003917068A5058234638 @default.
- W2003917068 hasAuthorship W2003917068A5060042484 @default.
- W2003917068 hasAuthorship W2003917068A5067780716 @default.
- W2003917068 hasAuthorship W2003917068A5068813714 @default.
- W2003917068 hasAuthorship W2003917068A5072851099 @default.
- W2003917068 hasAuthorship W2003917068A5076320186 @default.
- W2003917068 hasBestOaLocation W20039170682 @default.
- W2003917068 hasConcept C126322002 @default.
- W2003917068 hasConcept C134018914 @default.
- W2003917068 hasConcept C138976137 @default.
- W2003917068 hasConcept C181199279 @default.
- W2003917068 hasConcept C185592680 @default.
- W2003917068 hasConcept C198710026 @default.
- W2003917068 hasConcept C27016395 @default.
- W2003917068 hasConcept C2776980637 @default.
- W2003917068 hasConcept C2778525890 @default.
- W2003917068 hasConcept C28212737 @default.
- W2003917068 hasConcept C2908929049 @default.
- W2003917068 hasConcept C55493867 @default.
- W2003917068 hasConcept C71924100 @default.
- W2003917068 hasConcept C84393581 @default.
- W2003917068 hasConceptScore W2003917068C126322002 @default.
- W2003917068 hasConceptScore W2003917068C134018914 @default.
- W2003917068 hasConceptScore W2003917068C138976137 @default.
- W2003917068 hasConceptScore W2003917068C181199279 @default.
- W2003917068 hasConceptScore W2003917068C185592680 @default.
- W2003917068 hasConceptScore W2003917068C198710026 @default.
- W2003917068 hasConceptScore W2003917068C27016395 @default.
- W2003917068 hasConceptScore W2003917068C2776980637 @default.
- W2003917068 hasConceptScore W2003917068C2778525890 @default.
- W2003917068 hasConceptScore W2003917068C28212737 @default.
- W2003917068 hasConceptScore W2003917068C2908929049 @default.
- W2003917068 hasConceptScore W2003917068C55493867 @default.
- W2003917068 hasConceptScore W2003917068C71924100 @default.
- W2003917068 hasConceptScore W2003917068C84393581 @default.
- W2003917068 hasLocation W20039170681 @default.
- W2003917068 hasLocation W20039170682 @default.
- W2003917068 hasLocation W20039170683 @default.
- W2003917068 hasLocation W20039170684 @default.
- W2003917068 hasOpenAccess W2003917068 @default.
- W2003917068 hasPrimaryLocation W20039170681 @default.
- W2003917068 hasRelatedWork W146935509 @default.
- W2003917068 hasRelatedWork W1550989882 @default.
- W2003917068 hasRelatedWork W1965610155 @default.
- W2003917068 hasRelatedWork W2076569737 @default.
- W2003917068 hasRelatedWork W2167664552 @default.
- W2003917068 hasRelatedWork W2363957081 @default.
- W2003917068 hasRelatedWork W2390714419 @default.
- W2003917068 hasRelatedWork W2402685963 @default.
- W2003917068 hasRelatedWork W2406547830 @default.
- W2003917068 hasRelatedWork W2417665051 @default.
- W2003917068 isParatext "false" @default.
- W2003917068 isRetracted "false" @default.
- W2003917068 magId "2003917068" @default.
- W2003917068 workType "article" @default.