FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003923036> ?p ?o ?g. }

• W2003923036 endingPage "16942" @default.
• W2003923036 startingPage "16917" @default.
• W2003923036 abstract "Increased generation of reactive oxygen species (ROS) is a significant pathological feature in the brains of patients with Alzheimer’s disease (AD). Experimental evidence indicates that inhibition of brain ROS could be beneficial in slowing the neurodegenerative process triggered by amyloid-beta (Abeta) aggregates. The angiotensin II AT1 receptor is a significant source of brain ROS, and AD patients have an increased brain angiotensin-converting enzyme (ACE) level, which could account for an excessive angiotensin-dependent AT1-induced ROS generation. Therefore, we analyzed the impact of ACE inhibition on signs of neurodegeneration of aged Tg2576 mice as a transgenic animal model of AD. Whole genome microarray gene expression profiling and biochemical analyses demonstrated that the centrally active ACE inhibitor captopril normalized the excessive hippocampal ACE activity of AD mice. Concomitantly, the development of signs of neurodegeneration was retarded by six months of captopril treatment. The neuroprotective profile triggered by captopril was accompanied by reduced amyloidogenic processing of the amyloid precursor protein (APP), and decreased hippocampal ROS, which is known to enhance Abeta generation by increased activation of beta- and gamma-secretases. Taken together, our data present strong evidence that ACE inhibition with a widely used cardiovascular drug could interfere with Abeta-dependent neurodegeneration." @default.
• W2003923036 created "2016-06-24" @default.
• W2003923036 creator A5035742650 @default.
• W2003923036 creator A5038986573 @default.
• W2003923036 creator A5052474412 @default.
• W2003923036 creator A5052651149 @default.
• W2003923036 date "2013-08-16" @default.
• W2003923036 modified "2023-09-26" @default.
• W2003923036 title "ACE Inhibition with Captopril Retards the Development of Signs of Neurodegeneration in an Animal Model of Alzheimer’s Disease" @default.
• W2003923036 cites W1522338605 @default.
• W2003923036 cites W1550180955 @default.
• W2003923036 cites W1966621863 @default.
• W2003923036 cites W1969501720 @default.
• W2003923036 cites W1970838218 @default.
• W2003923036 cites W1977489043 @default.
• W2003923036 cites W1979612107 @default.
• W2003923036 cites W1982516779 @default.
• W2003923036 cites W1984994164 @default.
• W2003923036 cites W1996241810 @default.
• W2003923036 cites W1999061258 @default.
• W2003923036 cites W2001210466 @default.
• W2003923036 cites W2002181764 @default.
• W2003923036 cites W2006436888 @default.
• W2003923036 cites W2006870885 @default.
• W2003923036 cites W2011727503 @default.
• W2003923036 cites W2012358869 @default.
• W2003923036 cites W2032920422 @default.
• W2003923036 cites W2033016640 @default.
• W2003923036 cites W2033332566 @default.
• W2003923036 cites W2033710792 @default.
• W2003923036 cites W2036894466 @default.
• W2003923036 cites W2039057614 @default.
• W2003923036 cites W2044179716 @default.
• W2003923036 cites W2046847750 @default.
• W2003923036 cites W2048718653 @default.
• W2003923036 cites W2049582465 @default.
• W2003923036 cites W2051214521 @default.
• W2003923036 cites W2052321977 @default.
• W2003923036 cites W2052427120 @default.
• W2003923036 cites W2053431736 @default.
• W2003923036 cites W2056167556 @default.
• W2003923036 cites W2058342150 @default.
• W2003923036 cites W2060052435 @default.
• W2003923036 cites W2064502152 @default.
• W2003923036 cites W2067432590 @default.
• W2003923036 cites W2069140826 @default.
• W2003923036 cites W2084951515 @default.
• W2003923036 cites W2089443438 @default.
• W2003923036 cites W2094350545 @default.
• W2003923036 cites W2099240139 @default.
• W2003923036 cites W2102520727 @default.
• W2003923036 cites W2106274713 @default.
• W2003923036 cites W2125167727 @default.
• W2003923036 cites W2129139391 @default.
• W2003923036 cites W2133361358 @default.
• W2003923036 cites W2133836953 @default.
• W2003923036 cites W2139059737 @default.
• W2003923036 cites W2146172783 @default.
• W2003923036 cites W2160571418 @default.
• W2003923036 cites W2165474925 @default.
• W2003923036 cites W2167645268 @default.
• W2003923036 cites W2167886264 @default.
• W2003923036 cites W2332445905 @default.
• W2003923036 cites W2417218934 @default.
• W2003923036 cites W2429791019 @default.
• W2003923036 doi "https://doi.org/10.3390/ijms140816917" @default.
• W2003923036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3759943" @default.
• W2003923036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23959119" @default.
• W2003923036 hasPublicationYear "2013" @default.
• W2003923036 type Work @default.
• W2003923036 sameAs 2003923036 @default.
• W2003923036 citedByCount "77" @default.
• W2003923036 countsByYear W20039230362014 @default.
• W2003923036 countsByYear W20039230362015 @default.
• W2003923036 countsByYear W20039230362016 @default.
• W2003923036 countsByYear W20039230362017 @default.
• W2003923036 countsByYear W20039230362018 @default.
• W2003923036 countsByYear W20039230362019 @default.
• W2003923036 countsByYear W20039230362020 @default.
• W2003923036 countsByYear W20039230362021 @default.
• W2003923036 countsByYear W20039230362022 @default.
• W2003923036 countsByYear W20039230362023 @default.
• W2003923036 crossrefType "journal-article" @default.
• W2003923036 hasAuthorship W2003923036A5035742650 @default.
• W2003923036 hasAuthorship W2003923036A5038986573 @default.
• W2003923036 hasAuthorship W2003923036A5052474412 @default.
• W2003923036 hasAuthorship W2003923036A5052651149 @default.
• W2003923036 hasBestOaLocation W20039230361 @default.
• W2003923036 hasConcept C126322002 @default.
• W2003923036 hasConcept C134018914 @default.
• W2003923036 hasConcept C170493617 @default.
• W2003923036 hasConcept C185592680 @default.
• W2003923036 hasConcept C25498285 @default.
• W2003923036 hasConcept C2776151105 @default.
• W2003923036 hasConcept C2776156579 @default.
• W2003923036 hasConcept C2776925932 @default.
• W2003923036 hasConcept C2779134260 @default.
• W2003923036 hasConcept C2779479957 @default.

• next