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- W2003932503 abstract "We report on the outcomes of patients with metastatic oesophago-gastric (OG) cancer progressing after first-line platinum-based chemotherapy (PBCT) who received a re-challenge schedule of PBCT (r-PBCT) as second-line therapy.Patients with metastatic OG cancer treated with first-line PBCT (n = 138) between January 2009 and June 2013 were selected for the purpose of the study. Treatment-related outcomes were assessed including response rates, progression-free survival (PFS) and overall survival (OS).43 (32%) patients progressed (group A: platinum resistant (PR)) and 95 (68%) patients showed a response (group B: platinum sensitive (PS)) or had stable disease after first-line PBCT. Approximately 20% (9/43) of the patients in group A received second-line chemotherapy compared to 50% (38/80) in group B. Most patients (39/47) received r-PBCT, and the remaining patients (8/47) were treated with irinotecan-based chemotherapy. More than 50% (20/39) of the patients achieved disease control, with median PFS and OS of 3 months (95% confidence interval (CI) = 2.0-4.0 months) and 5.7 months (95% CI = 4.7-6.7 months) after commencement of r-PBCT. The actuarial median OS of patients responding to second-line or second and third lines of r-PBCT was 26.7 and 30.1 months, respectively.In platinum responders, r-PBCT appears to be an appropriate second-line option with survival outcomes comparable to those of other agents." @default.
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- W2003932503 date "2015-01-01" @default.
- W2003932503 modified "2023-09-23" @default.
- W2003932503 title "Retention of Platinum Sensitivity till Late Stages of Tumour Progression May Imply Improved Prognosis of Oesophageal and Gastric Cancers" @default.
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- W2003932503 doi "https://doi.org/10.1159/000371506" @default.
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