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• W2003933209 abstract "Clinical observations reveal that an augmented pace of T-cell recovery after chemotherapy correlates with improved tumor-free survival, suggesting the add-back of T cells after chemotherapy may improve outcomes. To evaluate adoptive immunotherapy treatment for B-lineage non-Hodgkin lymphoma (NHL), we expanded T cells from client-owned canines diagnosed with NHL on artificial antigen presenting cells (aAPC) in the presence of human interleukin (IL)-2 and IL-21. Graded doses of autologous T cells were infused after CHOP chemotherapy and persisted for 49 days, homed to tumor, and significantly improved survival. Serum thymidine kinase changes predicted T-cell engraftment, while anti-tumor effects correlated with neutrophil-to-lymphocyte ratios and granzyme B expression in manufactured T cells. Therefore, chemotherapy can be used to modulate infused T-cell responses to enhance anti-tumor effects. The companion canine model has translational implications for human immunotherapy which can be readily exploited since clinical-grade canine and human T cells are propagated using identical approaches." @default.
• W2003933209 created "2016-06-24" @default.
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• W2003933209 date "2012-02-13" @default.
• W2003933209 modified "2023-10-15" @default.
• W2003933209 title "Adoptive T-cell therapy improves treatment of canine non–Hodgkin lymphoma post chemotherapy" @default.
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• W2003933209 doi "https://doi.org/10.1038/srep00249" @default.
• W2003933209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3278154" @default.
• W2003933209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22355761" @default.
• W2003933209 hasPublicationYear "2012" @default.
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