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• W2003934384 abstract "Substituted 1,4-dihydropyridines were discovered as a novel and potent series of phosphodiesterase 4 (PDE4) inhibitors. Structure–activity relationships within this series have been carried out and studies revealed that the dihydropyridine core, with indole moiety and 3,4-dimethoxybenzyl group, is a potent analogue for PDE4 inhibition. These novel series of compounds were prepared via a 3-component reaction in a single pot. In vitro biological activity, modeling studies and crystallography data are also reported." @default.
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• W2003934384 date "2013-02-01" @default.
• W2003934384 modified "2023-10-11" @default.
• W2003934384 title "Discovery of novel 1,4-dihydropyridine-based PDE4 inhibitors" @default.
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• W2003934384 doi "https://doi.org/10.1016/j.bmcl.2012.11.121" @default.
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