FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003940239> ?p ?o ?g. }

• W2003940239 endingPage "28" @default.
• W2003940239 startingPage "20" @default.
• W2003940239 abstract "Carvedilol (Kredex, Coreg) is a multiple action antihypertensive drug that has been shown to protect cell membranes from lipid peroxidative damages. In this study the physical and structural effects of carvedilol on lipid bilayers are investigated by fluorescence techniques, differential scanning calorimetry and other physical methods. Carvedilol binds to liposomal membranes (9:1 DMPC:DMPG) strongly with an apparent binding constant on the order of 104 M−1 in PBS (pH 7.4). The characteristic changes in its intrinsic fluorescence properties when bound to liposomes suggest that this compound is situated in a non-polar environment. The Stern-Volmer and bimolecular quenching constants, determined using nitrate as the fluorescence quencher, for the free and bound carvedilol indicate that the carbazole moiety is at a depth of > 11 Å in the lipid bilayer. Fluorescence anisotropy measurements show that, unlike the membrane probes DPH and TMA-DPH, carvedilol is relatively mobile, and does not have a rigidly-defined molecular orientation in the bilayers. Differential scanning calorimetry results indicate that carvedilol is an effective membrane ‘fluidizer’ as it dose-dependently lowers the gel to liquid crystalline transition temperature and broadens the endothermic transition. Comparative studies of interactions of carbazole, 4-OH carbazole and carvedilol with the model liposomal membranes reveal a possible role of membrane-partitioning in their antioxidant efficacy. These findings are discussed in perspective with the membrane biophysical properties of different classes of therapeutic significant lipid antioxidants in mind." @default.
• W2003940239 created "2016-06-24" @default.
• W2003940239 creator A5003026401 @default.
• W2003940239 creator A5015754493 @default.
• W2003940239 creator A5016691477 @default.
• W2003940239 creator A5022908972 @default.
• W2003940239 creator A5046498981 @default.
• W2003940239 creator A5081027897 @default.
• W2003940239 date "1996-10-01" @default.
• W2003940239 modified "2023-10-10" @default.
• W2003940239 title "Carvedilol-liposome interaction: evidence for strong association with the hydrophobic region of the lipid bilayers" @default.
• W2003940239 cites W1495469243 @default.
• W2003940239 cites W1526223266 @default.
• W2003940239 cites W1554771869 @default.
• W2003940239 cites W1606086259 @default.
• W2003940239 cites W1970250390 @default.
• W2003940239 cites W1973392395 @default.
• W2003940239 cites W1981761946 @default.
• W2003940239 cites W1985752187 @default.
• W2003940239 cites W1991426745 @default.
• W2003940239 cites W1994516163 @default.
• W2003940239 cites W2000949681 @default.
• W2003940239 cites W2005847781 @default.
• W2003940239 cites W2032486494 @default.
• W2003940239 cites W2054526264 @default.
• W2003940239 cites W2062288759 @default.
• W2003940239 cites W2064818706 @default.
• W2003940239 cites W2069033951 @default.
• W2003940239 cites W2076044666 @default.
• W2003940239 cites W2076456149 @default.
• W2003940239 cites W2079380240 @default.
• W2003940239 cites W2083245140 @default.
• W2003940239 cites W2087576911 @default.
• W2003940239 cites W2112448291 @default.
• W2003940239 doi "https://doi.org/10.1016/0005-2736(96)00097-1" @default.
• W2003940239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8865810" @default.
• W2003940239 hasPublicationYear "1996" @default.
• W2003940239 type Work @default.
• W2003940239 sameAs 2003940239 @default.
• W2003940239 citedByCount "67" @default.
• W2003940239 countsByYear W20039402392012 @default.
• W2003940239 countsByYear W20039402392013 @default.
• W2003940239 countsByYear W20039402392014 @default.
• W2003940239 countsByYear W20039402392015 @default.
• W2003940239 countsByYear W20039402392016 @default.
• W2003940239 countsByYear W20039402392017 @default.
• W2003940239 countsByYear W20039402392018 @default.
• W2003940239 countsByYear W20039402392019 @default.
• W2003940239 countsByYear W20039402392020 @default.
• W2003940239 countsByYear W20039402392022 @default.
• W2003940239 crossrefType "journal-article" @default.
• W2003940239 hasAuthorship W2003940239A5003026401 @default.
• W2003940239 hasAuthorship W2003940239A5015754493 @default.
• W2003940239 hasAuthorship W2003940239A5016691477 @default.
• W2003940239 hasAuthorship W2003940239A5022908972 @default.
• W2003940239 hasAuthorship W2003940239A5046498981 @default.
• W2003940239 hasAuthorship W2003940239A5081027897 @default.
• W2003940239 hasBestOaLocation W20039402391 @default.
• W2003940239 hasConcept C111357860 @default.
• W2003940239 hasConcept C121332964 @default.
• W2003940239 hasConcept C121745418 @default.
• W2003940239 hasConcept C12554922 @default.
• W2003940239 hasConcept C126322002 @default.
• W2003940239 hasConcept C185154212 @default.
• W2003940239 hasConcept C185592680 @default.
• W2003940239 hasConcept C192157962 @default.
• W2003940239 hasConcept C2776127813 @default.
• W2003940239 hasConcept C2778198053 @default.
• W2003940239 hasConcept C2780591200 @default.
• W2003940239 hasConcept C39519442 @default.
• W2003940239 hasConcept C39944091 @default.
• W2003940239 hasConcept C41625074 @default.
• W2003940239 hasConcept C55493867 @default.
• W2003940239 hasConcept C62520636 @default.
• W2003940239 hasConcept C71924100 @default.
• W2003940239 hasConcept C75473681 @default.
• W2003940239 hasConcept C76564549 @default.
• W2003940239 hasConcept C8010536 @default.
• W2003940239 hasConcept C86803240 @default.
• W2003940239 hasConcept C91881484 @default.
• W2003940239 hasConcept C97355855 @default.
• W2003940239 hasConceptScore W2003940239C111357860 @default.
• W2003940239 hasConceptScore W2003940239C121332964 @default.
• W2003940239 hasConceptScore W2003940239C121745418 @default.
• W2003940239 hasConceptScore W2003940239C12554922 @default.
• W2003940239 hasConceptScore W2003940239C126322002 @default.
• W2003940239 hasConceptScore W2003940239C185154212 @default.
• W2003940239 hasConceptScore W2003940239C185592680 @default.
• W2003940239 hasConceptScore W2003940239C192157962 @default.
• W2003940239 hasConceptScore W2003940239C2776127813 @default.
• W2003940239 hasConceptScore W2003940239C2778198053 @default.
• W2003940239 hasConceptScore W2003940239C2780591200 @default.
• W2003940239 hasConceptScore W2003940239C39519442 @default.
• W2003940239 hasConceptScore W2003940239C39944091 @default.
• W2003940239 hasConceptScore W2003940239C41625074 @default.
• W2003940239 hasConceptScore W2003940239C55493867 @default.
• W2003940239 hasConceptScore W2003940239C62520636 @default.
• W2003940239 hasConceptScore W2003940239C71924100 @default.

• next