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- W2003944281 abstract "Significance Expression of a productively rearranged T-cell receptor (TCR)-β chain induces a program of αβ T-lineage differentiation, whereas thymocytes that productively rearranged TCR-γ and TCR-δ typically give rise to γδ-lineage T cells. However, given that all three TCR gene loci simultaneously undergo gene rearrangements, the possibility exists that a developing thymocyte may express a γδ-TCR together with a TCR-β or pre-TCR complex, and it is not clear to what this outcome would give rise in terms of T-lineage differentiation. Our findings point to a striking conclusion, in that rather than transmitting signals that exclusively promote αβ-lineage commitment/differentiation, the pre-TCR can function in concert with the γδ-TCR to promote γδ commitment/differentiation, a result that supports a signal strength model of αβ/γδ-lineage choice." @default.
- W2003944281 created "2016-06-24" @default.
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- W2003944281 date "2014-03-31" @default.
- W2003944281 modified "2023-09-24" @default.
- W2003944281 title "Enforcement of γδ-lineage commitment by the pre–T-cell receptor in precursors with weak γδ-TCR signals" @default.
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- W2003944281 doi "https://doi.org/10.1073/pnas.1312872111" @default.
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