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• W2003959098 abstract "Villus tip cells and crypt cells of rat jejunal mucosa were separated by the planning procedure of Imondi et al. and were studied with respect to their activities of the enzymes of the gamma-glutamyl cycle and glutathione content. The villus tip cells exhibit much higher gamma-glutamyl transpeptidase activities than do the crypt cells: thus, gamma-glutamyl trnaspeptidase appears to be a villus-specific enzyme. gamma-Glutamyl cyclotransferase and the enzymes required for glutathione synthesis are not specifically localized to either the crypt or villus tip cells but are present in both. The crypt cells have a high concentration of glutathione (4-5 mM) comparable to the levels found in liver and kidney; in contrast, the villus tip cells have much lower concentrations. On fasting, the glutathione concentration decreased markedly in both villus tip and crypt cells; feeding of protein, but not of sucrose, led to increased glutathione concentrations. The migration of cells from the undifferentiated crypt cell region to the villus tip is associated with structural and biochemical changes that equip the cell for its mature functional activities, which include transport. The present findings indicate that such cellular differentiation and migration is associated with a marked increase in gamma-glutamyl transpeptidase activity and in the utilization of glutathione." @default.
• W2003959098 created "2016-06-24" @default.
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• W2003959098 date "1976-02-01" @default.
• W2003959098 modified "2023-09-24" @default.
• W2003959098 title "Glutathione and gamma-glutamyl cycle enzymes in crypt and villus tip cells of rat jejunal mucosa." @default.
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• W2003959098 doi "https://doi.org/10.1073/pnas.73.2.420" @default.
• W2003959098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/335920" @default.
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