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• W2003970086 abstract "1 The pharmacokinetics and pharmacodynamics of lansoprazole, an antisecretory and antiulcer agent, were evaluated in 12 older (>60 years) and 12 younger (<60 years) healthy men. 2 Doses of lansoprazole (15 or 30 mg) or placebo were each given once daily for 7 consecutive days in this randomized, double-blind, three-way crossover study. Plasma concentrations and urinary excretion of lansoprazole and its metabolites, and gastric acid secretion were monitored after dosing on days 1 and 7 of each treatment period. 3 Within each age group, lansoprazole pharmacokinetics were linear. The mean clearance and elimination half-life of lansoprazole were about 40% lower and higher, respectively, in the older subjects (CL0: 12–14 vs 20–24 1 h−1; t1/2;, z: 1.90–2.19 vs 1.26–1.44 h). 4 At each dose level, acid secretion was more inhibited in the older group. However, the AUC associated with a 50% decrease in acid secretion was similar (849 vs 892 ng ml−1 h) for both age groups. Multiple dosing decreased the maximum possible inhibition more in the older group than in the younger group. 5 Since the decrease in acid output associated with equivalent AUCs on day 1 was similar for the two age groups, the greater difference between day 1 and day 7 secretion in the older group indicates that recovery of secretory activity may decline with increasing age." @default.
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• W2003970086 date "1993-11-01" @default.
• W2003970086 modified "2023-09-29" @default.
• W2003970086 title "Age-related differences in the pharmacokinetics and pharmacodynamics of lansoprazole" @default.
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• W2003970086 doi "https://doi.org/10.1111/j.1365-2125.1993.tb00386.x" @default.
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