Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003977592> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2003977592 endingPage "298" @default.
- W2003977592 startingPage "294" @default.
- W2003977592 abstract "[3H]Glycine blinding studies have been performed to further characterize polyamine interactions with the rat brain N-methyl-D-asparate (NMDA) receptor. Strychnine-insensitive [3H]glycine binding to washed cortical membranes was enhanced by spermine, spermidine, and hirudonin. Spermine stimulation of binding was additive with that produced by the NMDA receptor agonist L-glutamate. A high concentration of the L-glutamate antagonist 2-amino-5-phosphonovaleric acid reduced, but did not eliminate, spermine effects. Saturation experiments indicated that L-glutamate and spermine enhancement of binding was due to an increase in [3H]glycine binding affinity. Kinetic studies showed that optimal concentrations of spermine and L-glutamate reduced [3H]glycine association and dissociation rates by approximately fivefold and 30-fold, respectively. In competition experiments, the presence of L-glutamate and spermine had differential effects on the affinites of compounds that act as either agonists or antagonists at the glycine site of the NMDA receptor. The affinities of the agonists glycine, D-serine, and Dalanine, were increased about fivefold, while antagonist (HA-966, 7-chlorokynurenic acid) inhibitory potencies were unchanged. These data support our previous results showing that the NMDA receptor possesses a novel polyamine recognition site and demonstrate that these compounds directly modulate glycine's interactions with the receptor complex." @default.
- W2003977592 created "2016-06-24" @default.
- W2003977592 creator A5045313930 @default.
- W2003977592 creator A5071947883 @default.
- W2003977592 date "1990-01-01" @default.
- W2003977592 modified "2023-09-26" @default.
- W2003977592 title "Polyamines regulate glycine interaction with the N-methyl-D-aspartate receptor" @default.
- W2003977592 cites W15678485 @default.
- W2003977592 cites W159198934 @default.
- W2003977592 cites W1775749144 @default.
- W2003977592 cites W1964030958 @default.
- W2003977592 cites W1995056605 @default.
- W2003977592 cites W1997568797 @default.
- W2003977592 cites W1998347917 @default.
- W2003977592 cites W2012296805 @default.
- W2003977592 cites W2013933144 @default.
- W2003977592 cites W2018883950 @default.
- W2003977592 cites W2033877263 @default.
- W2003977592 cites W2034671642 @default.
- W2003977592 cites W2036137643 @default.
- W2003977592 cites W2036209909 @default.
- W2003977592 cites W2037380629 @default.
- W2003977592 cites W2044981704 @default.
- W2003977592 cites W2048152070 @default.
- W2003977592 cites W2067494870 @default.
- W2003977592 cites W2074791486 @default.
- W2003977592 cites W2075150500 @default.
- W2003977592 cites W2075970322 @default.
- W2003977592 cites W2078842109 @default.
- W2003977592 cites W2081678712 @default.
- W2003977592 cites W2111571310 @default.
- W2003977592 cites W2151399298 @default.
- W2003977592 cites W2170029299 @default.
- W2003977592 cites W967081 @default.
- W2003977592 doi "https://doi.org/10.1002/syn.890050406" @default.
- W2003977592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1972818" @default.
- W2003977592 hasPublicationYear "1990" @default.
- W2003977592 type Work @default.
- W2003977592 sameAs 2003977592 @default.
- W2003977592 citedByCount "77" @default.
- W2003977592 countsByYear W20039775922012 @default.
- W2003977592 countsByYear W20039775922013 @default.
- W2003977592 countsByYear W20039775922016 @default.
- W2003977592 countsByYear W20039775922019 @default.
- W2003977592 countsByYear W20039775922020 @default.
- W2003977592 crossrefType "journal-article" @default.
- W2003977592 hasAuthorship W2003977592A5045313930 @default.
- W2003977592 hasAuthorship W2003977592A5071947883 @default.
- W2003977592 hasConcept C170493617 @default.
- W2003977592 hasConcept C181199279 @default.
- W2003977592 hasConcept C185592680 @default.
- W2003977592 hasConcept C2776109719 @default.
- W2003977592 hasConcept C2777497464 @default.
- W2003977592 hasConcept C2777756961 @default.
- W2003977592 hasConcept C2778938600 @default.
- W2003977592 hasConcept C2780115381 @default.
- W2003977592 hasConcept C515207424 @default.
- W2003977592 hasConcept C55493867 @default.
- W2003977592 hasConcept C61174792 @default.
- W2003977592 hasConcept C67018056 @default.
- W2003977592 hasConcept C71240020 @default.
- W2003977592 hasConceptScore W2003977592C170493617 @default.
- W2003977592 hasConceptScore W2003977592C181199279 @default.
- W2003977592 hasConceptScore W2003977592C185592680 @default.
- W2003977592 hasConceptScore W2003977592C2776109719 @default.
- W2003977592 hasConceptScore W2003977592C2777497464 @default.
- W2003977592 hasConceptScore W2003977592C2777756961 @default.
- W2003977592 hasConceptScore W2003977592C2778938600 @default.
- W2003977592 hasConceptScore W2003977592C2780115381 @default.
- W2003977592 hasConceptScore W2003977592C515207424 @default.
- W2003977592 hasConceptScore W2003977592C55493867 @default.
- W2003977592 hasConceptScore W2003977592C61174792 @default.
- W2003977592 hasConceptScore W2003977592C67018056 @default.
- W2003977592 hasConceptScore W2003977592C71240020 @default.
- W2003977592 hasIssue "4" @default.
- W2003977592 hasLocation W20039775921 @default.
- W2003977592 hasLocation W20039775922 @default.
- W2003977592 hasOpenAccess W2003977592 @default.
- W2003977592 hasPrimaryLocation W20039775921 @default.
- W2003977592 hasRelatedWork W1489257408 @default.
- W2003977592 hasRelatedWork W1981217765 @default.
- W2003977592 hasRelatedWork W2003977592 @default.
- W2003977592 hasRelatedWork W2018708466 @default.
- W2003977592 hasRelatedWork W2022953737 @default.
- W2003977592 hasRelatedWork W2083978084 @default.
- W2003977592 hasRelatedWork W2109675090 @default.
- W2003977592 hasRelatedWork W213470323 @default.
- W2003977592 hasRelatedWork W2320607179 @default.
- W2003977592 hasRelatedWork W2443580346 @default.
- W2003977592 hasVolume "5" @default.
- W2003977592 isParatext "false" @default.
- W2003977592 isRetracted "false" @default.
- W2003977592 magId "2003977592" @default.
- W2003977592 workType "article" @default.