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- W2003983795 abstract "The 1,3-dipolar cycloaddition reaction between nitrile imines and resin-bound enamines gives resin-bound pyrazoline intermediates. The piperazine resin functions as a traceless linker and allows these intermediates to be cleaved directly from the resin under mild acid conditions to afford 1,4-diarylpyrazoles. Alternatively they may be chemically modified on the resin prior to elimination from the polymer. The cycloaddition–elimination sequence is regiospecific for the 3,4-disubstituted pyrazole isomer and the products are obtained in good to high yield and in high purity." @default.
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- W2003983795 date "2001-10-11" @default.
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- W2003983795 title "Cycloaddition of nitrile imines to resin-bound enamines: a solid phase synthesis of 1,4-diarylpyrazoles" @default.
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- W2003983795 doi "https://doi.org/10.1039/b102913b" @default.
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