FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003991622> ?p ?o ?g. }

• W2003991622 endingPage "197" @default.
• W2003991622 startingPage "192" @default.
• W2003991622 abstract "BackgroundCD11b belongs to the integrin family and is expressed on neutrophils, monocytes, natural killer cells, and a subset of lymphocytes. Although CD11b expressed on neutrophils and monocytes has been extensively investigated and has been reported to play an important role in the migration of these subsets of leukocytes, the function of CD11b expressed on a subset of B cells has not yet been clarified.ObjectiveTo elucidate the functional activity of CD11b expressed on B cells, we characterized the CD11b-expressing cells among the B-cell population and investigated their migratory ability.MethodsIsolated peripheral blood CD19+ B cells were analyzed by flow cytometry. The migratory ability of B cells was evaluated by the transwell assay, and the contribution of CD11b to this ability was investigated by using an anti-CD11b blocking mAb.ResultsThe majority of CD27−IgD+ naive B cells were CD11b−, whereas most CD27+ memory cells were CD11b+. Among the CD27+ memory cells, expression of CD11b was stronger on the IgD− cells than on the IgD+ cells. In the transwell assay, the migrating cells were predominantly CD27+IgD− cells, most of which expressed CD11b. The addition of an anti-CD11b blocking mAb resulted in the significant reduction of the number of migrating B cells.ConclusionMemory B cells express CD11b and, in contrast with naive B cells, have high migratory ability. CD11b plays an essential role in the homing process of memory cells. CD11b belongs to the integrin family and is expressed on neutrophils, monocytes, natural killer cells, and a subset of lymphocytes. Although CD11b expressed on neutrophils and monocytes has been extensively investigated and has been reported to play an important role in the migration of these subsets of leukocytes, the function of CD11b expressed on a subset of B cells has not yet been clarified. To elucidate the functional activity of CD11b expressed on B cells, we characterized the CD11b-expressing cells among the B-cell population and investigated their migratory ability. Isolated peripheral blood CD19+ B cells were analyzed by flow cytometry. The migratory ability of B cells was evaluated by the transwell assay, and the contribution of CD11b to this ability was investigated by using an anti-CD11b blocking mAb. The majority of CD27−IgD+ naive B cells were CD11b−, whereas most CD27+ memory cells were CD11b+. Among the CD27+ memory cells, expression of CD11b was stronger on the IgD− cells than on the IgD+ cells. In the transwell assay, the migrating cells were predominantly CD27+IgD− cells, most of which expressed CD11b. The addition of an anti-CD11b blocking mAb resulted in the significant reduction of the number of migrating B cells. Memory B cells express CD11b and, in contrast with naive B cells, have high migratory ability. CD11b plays an essential role in the homing process of memory cells." @default.
• W2003991622 created "2016-06-24" @default.
• W2003991622 creator A5008164044 @default.
• W2003991622 creator A5012712597 @default.
• W2003991622 creator A5027839397 @default.
• W2003991622 creator A5030266738 @default.
• W2003991622 creator A5031399771 @default.
• W2003991622 creator A5040731065 @default.
• W2003991622 creator A5058457727 @default.
• W2003991622 creator A5059967481 @default.
• W2003991622 creator A5061490794 @default.
• W2003991622 creator A5077597600 @default.
• W2003991622 creator A5089365235 @default.
• W2003991622 date "2005-07-01" @default.
• W2003991622 modified "2023-10-16" @default.
• W2003991622 title "CD11b-mediated migratory property of peripheral blood B cells" @default.
• W2003991622 cites W1490715552 @default.
• W2003991622 cites W1491020406 @default.
• W2003991622 cites W1863355121 @default.
• W2003991622 cites W1864980226 @default.
• W2003991622 cites W1866019784 @default.
• W2003991622 cites W1915418173 @default.
• W2003991622 cites W1966286149 @default.
• W2003991622 cites W1979640049 @default.
• W2003991622 cites W1982836586 @default.
• W2003991622 cites W1989139783 @default.
• W2003991622 cites W1994135361 @default.
• W2003991622 cites W2003205622 @default.
• W2003991622 cites W2003298736 @default.
• W2003991622 cites W2013280517 @default.
• W2003991622 cites W2037876636 @default.
• W2003991622 cites W2042626190 @default.
• W2003991622 cites W2063229653 @default.
• W2003991622 cites W2063229662 @default.
• W2003991622 cites W2085233986 @default.
• W2003991622 cites W2100336468 @default.
• W2003991622 cites W2116370657 @default.
• W2003991622 cites W2136581630 @default.
• W2003991622 cites W2146981926 @default.
• W2003991622 cites W2153450942 @default.
• W2003991622 cites W2163206714 @default.
• W2003991622 cites W2164431774 @default.
• W2003991622 cites W2167808722 @default.
• W2003991622 cites W24380480 @default.
• W2003991622 cites W4211183850 @default.
• W2003991622 cites W4313169499 @default.
• W2003991622 doi "https://doi.org/10.1016/j.jaci.2005.03.021" @default.
• W2003991622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15990794" @default.
• W2003991622 hasPublicationYear "2005" @default.
• W2003991622 type Work @default.
• W2003991622 sameAs 2003991622 @default.
• W2003991622 citedByCount "52" @default.
• W2003991622 countsByYear W20039916222013 @default.
• W2003991622 countsByYear W20039916222014 @default.
• W2003991622 countsByYear W20039916222015 @default.
• W2003991622 countsByYear W20039916222016 @default.
• W2003991622 countsByYear W20039916222017 @default.
• W2003991622 countsByYear W20039916222018 @default.
• W2003991622 countsByYear W20039916222019 @default.
• W2003991622 countsByYear W20039916222020 @default.
• W2003991622 countsByYear W20039916222021 @default.
• W2003991622 countsByYear W20039916222022 @default.
• W2003991622 countsByYear W20039916222023 @default.
• W2003991622 crossrefType "journal-article" @default.
• W2003991622 hasAuthorship W2003991622A5008164044 @default.
• W2003991622 hasAuthorship W2003991622A5012712597 @default.
• W2003991622 hasAuthorship W2003991622A5027839397 @default.
• W2003991622 hasAuthorship W2003991622A5030266738 @default.
• W2003991622 hasAuthorship W2003991622A5031399771 @default.
• W2003991622 hasAuthorship W2003991622A5040731065 @default.
• W2003991622 hasAuthorship W2003991622A5058457727 @default.
• W2003991622 hasAuthorship W2003991622A5059967481 @default.
• W2003991622 hasAuthorship W2003991622A5061490794 @default.
• W2003991622 hasAuthorship W2003991622A5077597600 @default.
• W2003991622 hasAuthorship W2003991622A5089365235 @default.
• W2003991622 hasBestOaLocation W20039916221 @default.
• W2003991622 hasConcept C139563560 @default.
• W2003991622 hasConcept C153911025 @default.
• W2003991622 hasConcept C159654299 @default.
• W2003991622 hasConcept C171779818 @default.
• W2003991622 hasConcept C185592680 @default.
• W2003991622 hasConcept C200180986 @default.
• W2003991622 hasConcept C203014093 @default.
• W2003991622 hasConcept C2776090121 @default.
• W2003991622 hasConcept C2778453870 @default.
• W2003991622 hasConcept C2778957590 @default.
• W2003991622 hasConcept C48010095 @default.
• W2003991622 hasConcept C553184892 @default.
• W2003991622 hasConcept C67662055 @default.
• W2003991622 hasConcept C86803240 @default.
• W2003991622 hasConcept C8891405 @default.
• W2003991622 hasConcept C95444343 @default.
• W2003991622 hasConceptScore W2003991622C139563560 @default.
• W2003991622 hasConceptScore W2003991622C153911025 @default.
• W2003991622 hasConceptScore W2003991622C159654299 @default.
• W2003991622 hasConceptScore W2003991622C171779818 @default.
• W2003991622 hasConceptScore W2003991622C185592680 @default.
• W2003991622 hasConceptScore W2003991622C200180986 @default.

• next