FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003992236> ?p ?o ?g. }

• W2003992236 endingPage "37" @default.
• W2003992236 startingPage "26" @default.
• W2003992236 abstract "Cyclic AMP (cAMP) and Ca(2+) are key regulators of exocytosis in many cells, including insulin-secreting beta cells. Glucose-stimulated insulin secretion from beta cells is pulsatile and involves oscillations of the cytoplasmic Ca(2+) concentration ([Ca(2+)](i)), but little is known about the detailed kinetics of cAMP signaling. Using evanescent-wave fluorescence imaging we found that glucose induces pronounced oscillations of cAMP in the submembrane space of single MIN6 cells and primary mouse beta cells. These oscillations were preceded and enhanced by elevations of [Ca(2+)](i). However, conditions raising cytoplasmic ATP could trigger cAMP elevations without accompanying [Ca(2+)](i) rise, indicating that adenylyl cyclase activity may be controlled also by the substrate concentration. The cAMP oscillations correlated with pulsatile insulin release. Whereas elevation of cAMP enhanced secretion, inhibition of adenylyl cyclases suppressed both cAMP oscillations and pulsatile insulin release. We conclude that cell metabolism directly controls cAMP and that glucose-induced cAMP oscillations regulate the magnitude and kinetics of insulin exocytosis." @default.
• W2003992236 created "2016-06-24" @default.
• W2003992236 creator A5020082293 @default.
• W2003992236 creator A5055074357 @default.
• W2003992236 creator A5056946780 @default.
• W2003992236 creator A5059283425 @default.
• W2003992236 creator A5059407062 @default.
• W2003992236 creator A5059968213 @default.
• W2003992236 creator A5061235654 @default.
• W2003992236 creator A5078731683 @default.
• W2003992236 creator A5084125183 @default.
• W2003992236 date "2008-07-01" @default.
• W2003992236 modified "2023-10-13" @default.
• W2003992236 title "Glucose-Induced Cyclic AMP Oscillations Regulate Pulsatile Insulin Secretion" @default.
• W2003992236 cites W1520363389 @default.
• W2003992236 cites W1543532453 @default.
• W2003992236 cites W1743153984 @default.
• W2003992236 cites W1933247863 @default.
• W2003992236 cites W1964988818 @default.
• W2003992236 cites W1965420509 @default.
• W2003992236 cites W1968498807 @default.
• W2003992236 cites W1968823870 @default.
• W2003992236 cites W1975347125 @default.
• W2003992236 cites W1985807238 @default.
• W2003992236 cites W1988101921 @default.
• W2003992236 cites W1988196562 @default.
• W2003992236 cites W1993257524 @default.
• W2003992236 cites W2001042052 @default.
• W2003992236 cites W2001253603 @default.
• W2003992236 cites W2009445873 @default.
• W2003992236 cites W2009770052 @default.
• W2003992236 cites W2011375238 @default.
• W2003992236 cites W2013910844 @default.
• W2003992236 cites W2014716037 @default.
• W2003992236 cites W2016155662 @default.
• W2003992236 cites W2016501481 @default.
• W2003992236 cites W2021617274 @default.
• W2003992236 cites W2023556678 @default.
• W2003992236 cites W2025659430 @default.
• W2003992236 cites W2026045809 @default.
• W2003992236 cites W2036441475 @default.
• W2003992236 cites W2040065594 @default.
• W2003992236 cites W2049927057 @default.
• W2003992236 cites W2051338604 @default.
• W2003992236 cites W2059899106 @default.
• W2003992236 cites W2064224049 @default.
• W2003992236 cites W2065909056 @default.
• W2003992236 cites W2076010563 @default.
• W2003992236 cites W2083049815 @default.
• W2003992236 cites W2088022780 @default.
• W2003992236 cites W2089683741 @default.
• W2003992236 cites W2092996376 @default.
• W2003992236 cites W2105100736 @default.
• W2003992236 cites W2108528688 @default.
• W2003992236 cites W2123410845 @default.
• W2003992236 cites W2125346049 @default.
• W2003992236 cites W2126384224 @default.
• W2003992236 cites W2128167237 @default.
• W2003992236 cites W2132061790 @default.
• W2003992236 cites W2136460746 @default.
• W2003992236 cites W2141063928 @default.
• W2003992236 cites W2141260882 @default.
• W2003992236 cites W2143970143 @default.
• W2003992236 cites W2161546239 @default.
• W2003992236 cites W2164561590 @default.
• W2003992236 cites W2166666951 @default.
• W2003992236 cites W2176847545 @default.
• W2003992236 cites W2218148748 @default.
• W2003992236 cites W2279950559 @default.
• W2003992236 cites W4253422011 @default.
• W2003992236 doi "https://doi.org/10.1016/j.cmet.2008.06.003" @default.
• W2003992236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18590690" @default.
• W2003992236 hasPublicationYear "2008" @default.
• W2003992236 type Work @default.
• W2003992236 sameAs 2003992236 @default.
• W2003992236 citedByCount "174" @default.
• W2003992236 countsByYear W20039922362012 @default.
• W2003992236 countsByYear W20039922362013 @default.
• W2003992236 countsByYear W20039922362014 @default.
• W2003992236 countsByYear W20039922362015 @default.
• W2003992236 countsByYear W20039922362016 @default.
• W2003992236 countsByYear W20039922362017 @default.
• W2003992236 countsByYear W20039922362018 @default.
• W2003992236 countsByYear W20039922362019 @default.
• W2003992236 countsByYear W20039922362020 @default.
• W2003992236 countsByYear W20039922362021 @default.
• W2003992236 countsByYear W20039922362022 @default.
• W2003992236 countsByYear W20039922362023 @default.
• W2003992236 crossrefType "journal-article" @default.
• W2003992236 hasAuthorship W2003992236A5020082293 @default.
• W2003992236 hasAuthorship W2003992236A5055074357 @default.
• W2003992236 hasAuthorship W2003992236A5056946780 @default.
• W2003992236 hasAuthorship W2003992236A5059283425 @default.
• W2003992236 hasAuthorship W2003992236A5059407062 @default.
• W2003992236 hasAuthorship W2003992236A5059968213 @default.
• W2003992236 hasAuthorship W2003992236A5061235654 @default.
• W2003992236 hasAuthorship W2003992236A5078731683 @default.
• W2003992236 hasAuthorship W2003992236A5084125183 @default.

• next