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- W2003992813 abstract "Glioblastoma (GBM) is an aggressive cancer with dismal survival rates and few new treatment options. Fluorescenceguided resection of GBM followed by photodynamic therapy (PDT) has shown promise in several chemo- orradiotherapy non-responsive GBM treatments clinically. PDT is an emerging light and photosensitizer (PS) mediatedcytotoxic method. However, as with other therapeutic modalities, the outcomes are variable largely due to the nonpersonalizationof dose parameters. The variability can be attributed to the differences in heterogeneous photosensitizeraccumulation in tumors. Building upon our previous findings on utilizing PS fluorescence for designing tumor-specificPDT dose, we explore the use of photoacoustic imaging, a technique that provides contrast based on the tissue opticalabsorption properties, to obtain 3D information on the tumoral photosensitizer accumulation. The findings of this studywill form the basis for customized photodynamic therapy for glioblastoma and have the potential to serve as a platformfor treatment of other cancers." @default.
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- W2003992813 date "2013-03-13" @default.
- W2003992813 modified "2023-09-29" @default.
- W2003992813 title "Towards image-guided photodynamic therapy of Glioblastoma" @default.
- W2003992813 doi "https://doi.org/10.1117/12.2010684" @default.
- W2003992813 hasPublicationYear "2013" @default.
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