FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003993233> ?p ?o ?g. }

• W2003993233 endingPage "3644" @default.
• W2003993233 startingPage "3635" @default.
• W2003993233 abstract "Export of cargo from the endoplasmic reticulum (ER) is the first membrane trafficking step in the secretory pathway. To date, all cargo proteins appear to use a common set of machinery for the initial stages of export, namely the COPII coat complex. Recent data from both yeast and mammalian systems have emerged suggesting that specific cargoes could be sorted from one another at the point of exit from the endoplasmic reticulum or immediately afterwards. Here, we have examined the mechanisms used for export of different types of cargo molecule from the endoplasmic reticulum. All cargoes examined utilise the COPII machinery, but specific differences are seen in the accumulation of cargo into ER-derived pre-budding complexes following expression of a GTP-restricted mutant of the Sar1p GTPase. Glycosylphosphatidylinositol (GPI)-anchored GFP is seen to be restricted to the ER under these conditions whereas other cargoes, including ts045-G and lumFP accumulate in pre-budding complexes. Following exit, GPI-FP, lumFP and ts045-G-FP all travel to the Golgi in the same vesicular tubular clusters (VTCs). These data show a differential requirement for efficient GTP hydrolysis by the Sar1p GTPase in export of cargo from the ER." @default.
• W2003993233 created "2016-06-24" @default.
• W2003993233 creator A5004412496 @default.
• W2003993233 creator A5017298007 @default.
• W2003993233 date "2004-07-15" @default.
• W2003993233 modified "2023-10-16" @default.
• W2003993233 title "Differential effects of a GTP-restricted mutant of Sar1p on segregation of cargo during export from the endoplasmic reticulum" @default.
• W2003993233 cites W1499112972 @default.
• W2003993233 cites W1503628938 @default.
• W2003993233 cites W1523680394 @default.
• W2003993233 cites W1535587662 @default.
• W2003993233 cites W1769996142 @default.
• W2003993233 cites W1895206111 @default.
• W2003993233 cites W1914535079 @default.
• W2003993233 cites W1943315667 @default.
• W2003993233 cites W1964906411 @default.
• W2003993233 cites W1969963064 @default.
• W2003993233 cites W1971476311 @default.
• W2003993233 cites W1975811004 @default.
• W2003993233 cites W1982615333 @default.
• W2003993233 cites W1991736711 @default.
• W2003993233 cites W2002426370 @default.
• W2003993233 cites W2006287134 @default.
• W2003993233 cites W2016851915 @default.
• W2003993233 cites W2029152767 @default.
• W2003993233 cites W2029843133 @default.
• W2003993233 cites W2029983725 @default.
• W2003993233 cites W2041674095 @default.
• W2003993233 cites W2066976004 @default.
• W2003993233 cites W2074897257 @default.
• W2003993233 cites W2077652151 @default.
• W2003993233 cites W2093546518 @default.
• W2003993233 cites W2094503700 @default.
• W2003993233 cites W2097707959 @default.
• W2003993233 cites W2097996196 @default.
• W2003993233 cites W2107312415 @default.
• W2003993233 cites W2109975639 @default.
• W2003993233 cites W2116944145 @default.
• W2003993233 cites W2119548436 @default.
• W2003993233 cites W2131544701 @default.
• W2003993233 cites W2134245600 @default.
• W2003993233 cites W2134403233 @default.
• W2003993233 cites W2134576488 @default.
• W2003993233 cites W2135998691 @default.
• W2003993233 cites W2138062841 @default.
• W2003993233 cites W2140167060 @default.
• W2003993233 cites W2143992953 @default.
• W2003993233 cites W2149743336 @default.
• W2003993233 cites W2153776880 @default.
• W2003993233 cites W2156303060 @default.
• W2003993233 cites W2159362830 @default.
• W2003993233 cites W2162194520 @default.
• W2003993233 cites W2169825983 @default.
• W2003993233 cites W2171495269 @default.
• W2003993233 cites W2181827540 @default.
• W2003993233 cites W2186139098 @default.
• W2003993233 cites W232306754 @default.
• W2003993233 cites W2460719811 @default.
• W2003993233 doi "https://doi.org/10.1242/jcs.01269" @default.
• W2003993233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15252131" @default.
• W2003993233 hasPublicationYear "2004" @default.
• W2003993233 type Work @default.
• W2003993233 sameAs 2003993233 @default.
• W2003993233 citedByCount "35" @default.
• W2003993233 countsByYear W20039932332012 @default.
• W2003993233 countsByYear W20039932332014 @default.
• W2003993233 countsByYear W20039932332015 @default.
• W2003993233 countsByYear W20039932332016 @default.
• W2003993233 countsByYear W20039932332020 @default.
• W2003993233 countsByYear W20039932332021 @default.
• W2003993233 crossrefType "journal-article" @default.
• W2003993233 hasAuthorship W2003993233A5004412496 @default.
• W2003993233 hasAuthorship W2003993233A5017298007 @default.
• W2003993233 hasConcept C102568950 @default.
• W2003993233 hasConcept C104317684 @default.
• W2003993233 hasConcept C118716 @default.
• W2003993233 hasConcept C119062480 @default.
• W2003993233 hasConcept C143065580 @default.
• W2003993233 hasConcept C158617107 @default.
• W2003993233 hasConcept C181199279 @default.
• W2003993233 hasConcept C190062978 @default.
• W2003993233 hasConcept C206912223 @default.
• W2003993233 hasConcept C207332259 @default.
• W2003993233 hasConcept C2777867350 @default.
• W2003993233 hasConcept C2910636507 @default.
• W2003993233 hasConcept C46617944 @default.
• W2003993233 hasConcept C55493867 @default.
• W2003993233 hasConcept C6492254 @default.
• W2003993233 hasConcept C86803240 @default.
• W2003993233 hasConcept C95444343 @default.
• W2003993233 hasConceptScore W2003993233C102568950 @default.
• W2003993233 hasConceptScore W2003993233C104317684 @default.
• W2003993233 hasConceptScore W2003993233C118716 @default.
• W2003993233 hasConceptScore W2003993233C119062480 @default.
• W2003993233 hasConceptScore W2003993233C143065580 @default.
• W2003993233 hasConceptScore W2003993233C158617107 @default.
• W2003993233 hasConceptScore W2003993233C181199279 @default.
• W2003993233 hasConceptScore W2003993233C190062978 @default.

• next