FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003993752> ?p ?o ?g. }

• W2003993752 endingPage "4333" @default.
• W2003993752 startingPage "4328" @default.
• W2003993752 abstract "Allosteric proteins use energy derived from ligand binding to promote a global change in conformation. The gating equilibrium constant of acetylcholine receptor-channels (AChRs) is influenced by ligands, mutations, and membrane voltage. We engineered AChRs to have specific values of this constant by combining these perturbations, and then calculated the corresponding values for a reference condition. AChRs were designed to have specific rate and equilibrium constants simply by adding multiple, energetically independent mutations with known effects on gating. Mutations and depolarization (to remove channel block) changed the diliganded gating equilibrium constant only by changing the unliganded gating equilibrium constant (E(0)) and did not alter the energy from ligand binding. All of the tested perturbations were approximately energetically independent. We conclude that naturally occurring mutations mainly adjust E(0) and cause human disease because they generate AChRs that have physiologically inappropriate values of this constant. The results suggest that the energy associated with a structural change of a side chain in the gating isomerization is dissipated locally and is mainly independent of rigid body or normal mode motions of the protein. Gating rate and equilibrium constants are estimated for seven different AChR agonists using a stepwise engineering approach." @default.
• W2003993752 created "2016-06-24" @default.
• W2003993752 creator A5020091222 @default.
• W2003993752 creator A5022887305 @default.
• W2003993752 creator A5045534329 @default.
• W2003993752 creator A5050511467 @default.
• W2003993752 creator A5064835126 @default.
• W2003993752 date "2011-03-01" @default.
• W2003993752 modified "2023-10-02" @default.
• W2003993752 title "Design and control of acetylcholine receptor conformational change" @default.
• W2003993752 cites W1632324362 @default.
• W2003993752 cites W1965359689 @default.
• W2003993752 cites W1977242895 @default.
• W2003993752 cites W1981857440 @default.
• W2003993752 cites W1998093640 @default.
• W2003993752 cites W2000860313 @default.
• W2003993752 cites W2003468829 @default.
• W2003993752 cites W2012605007 @default.
• W2003993752 cites W2017754929 @default.
• W2003993752 cites W2019143250 @default.
• W2003993752 cites W2025874457 @default.
• W2003993752 cites W2026193902 @default.
• W2003993752 cites W2032892621 @default.
• W2003993752 cites W2042940622 @default.
• W2003993752 cites W2050224291 @default.
• W2003993752 cites W2074890710 @default.
• W2003993752 cites W2077981340 @default.
• W2003993752 cites W2083375544 @default.
• W2003993752 cites W2085913208 @default.
• W2003993752 cites W2089817117 @default.
• W2003993752 cites W2094929016 @default.
• W2003993752 cites W2101014022 @default.
• W2003993752 cites W2121222517 @default.
• W2003993752 cites W2124927907 @default.
• W2003993752 cites W2125278854 @default.
• W2003993752 cites W2128177218 @default.
• W2003993752 cites W2130881414 @default.
• W2003993752 cites W2143014450 @default.
• W2003993752 cites W2148421905 @default.
• W2003993752 cites W2159006731 @default.
• W2003993752 cites W2164750874 @default.
• W2003993752 cites W2170963483 @default.
• W2003993752 cites W4298752002 @default.
• W2003993752 doi "https://doi.org/10.1073/pnas.1016617108" @default.
• W2003993752 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3060238" @default.
• W2003993752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21368211" @default.
• W2003993752 hasPublicationYear "2011" @default.
• W2003993752 type Work @default.
• W2003993752 sameAs 2003993752 @default.
• W2003993752 citedByCount "48" @default.
• W2003993752 countsByYear W20039937522012 @default.
• W2003993752 countsByYear W20039937522013 @default.
• W2003993752 countsByYear W20039937522014 @default.
• W2003993752 countsByYear W20039937522015 @default.
• W2003993752 countsByYear W20039937522016 @default.
• W2003993752 countsByYear W20039937522017 @default.
• W2003993752 countsByYear W20039937522019 @default.
• W2003993752 countsByYear W20039937522020 @default.
• W2003993752 countsByYear W20039937522021 @default.
• W2003993752 countsByYear W20039937522022 @default.
• W2003993752 countsByYear W20039937522023 @default.
• W2003993752 crossrefType "journal-article" @default.
• W2003993752 hasAuthorship W2003993752A5020091222 @default.
• W2003993752 hasAuthorship W2003993752A5022887305 @default.
• W2003993752 hasAuthorship W2003993752A5045534329 @default.
• W2003993752 hasAuthorship W2003993752A5050511467 @default.
• W2003993752 hasAuthorship W2003993752A5064835126 @default.
• W2003993752 hasBestOaLocation W20039937521 @default.
• W2003993752 hasConcept C10710636 @default.
• W2003993752 hasConcept C116569031 @default.
• W2003993752 hasConcept C119599485 @default.
• W2003993752 hasConcept C12554922 @default.
• W2003993752 hasConcept C127413603 @default.
• W2003993752 hasConcept C147789679 @default.
• W2003993752 hasConcept C166342909 @default.
• W2003993752 hasConcept C170493617 @default.
• W2003993752 hasConcept C185592680 @default.
• W2003993752 hasConcept C194544171 @default.
• W2003993752 hasConcept C2777339483 @default.
• W2003993752 hasConcept C55493867 @default.
• W2003993752 hasConcept C71240020 @default.
• W2003993752 hasConcept C80161118 @default.
• W2003993752 hasConcept C81370116 @default.
• W2003993752 hasConcept C86803240 @default.
• W2003993752 hasConceptScore W2003993752C10710636 @default.
• W2003993752 hasConceptScore W2003993752C116569031 @default.
• W2003993752 hasConceptScore W2003993752C119599485 @default.
• W2003993752 hasConceptScore W2003993752C12554922 @default.
• W2003993752 hasConceptScore W2003993752C127413603 @default.
• W2003993752 hasConceptScore W2003993752C147789679 @default.
• W2003993752 hasConceptScore W2003993752C166342909 @default.
• W2003993752 hasConceptScore W2003993752C170493617 @default.
• W2003993752 hasConceptScore W2003993752C185592680 @default.
• W2003993752 hasConceptScore W2003993752C194544171 @default.
• W2003993752 hasConceptScore W2003993752C2777339483 @default.
• W2003993752 hasConceptScore W2003993752C55493867 @default.
• W2003993752 hasConceptScore W2003993752C71240020 @default.
• W2003993752 hasConceptScore W2003993752C80161118 @default.

• next