FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003994310> ?p ?o ?g. }

• W2003994310 endingPage "367" @default.
• W2003994310 startingPage "363" @default.
• W2003994310 abstract "Molecular mimicry was proposed as a potential mechanism for streptococcal sequelae leading to rheumatic fever (RF) and rheumatic heart disease (RHD). CD4(+)infiltrating T cells are able to recognize streptococcal M peptides and heart tissue proteins. We analyzed the M5 peptide- and heart-specific responses, cytokine profile and T cell receptor (TCR) BV usage from peripheral and heart-infiltrating T cell lines and clones from patients across the clinical spectrum of ARF/RHD. The patient with ARF displayed a higher frequency of mitral valve infiltrating T cell clones reactive against M5: 1-25, 81-103 and 163-177 regions and several valve-derived proteins than the post-RF and chronic RHD patient (67%; 20% and 27%, respectively). The presence of oligoclonal BV families indicative of oligoclonal T cell expansion among mitral valve-derived T cell lines was increased in the chronic RHD patient. Furthermore, mitral valve T cell lines from all patients produced significant amounts of inflammatory cytokines interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNFalpha) in response to M5(81-96) peptide, with the highest production attained by the chronic RHD patient. These data are consistent with an important role for M5 peptide and host antigen-driven, T1-type CD4(+)T cells in the pathogenesis of RHD and heart lesion progression after recurrence of the streptococcal infection." @default.
• W2003994310 created "2016-06-24" @default.
• W2003994310 creator A5000888675 @default.
• W2003994310 creator A5033255349 @default.
• W2003994310 creator A5038430349 @default.
• W2003994310 creator A5063842988 @default.
• W2003994310 creator A5071449715 @default.
• W2003994310 creator A5087639158 @default.
• W2003994310 date "2001-05-01" @default.
• W2003994310 modified "2023-10-18" @default.
• W2003994310 title "Heart-directed Autoimmunity: the Case of Rheumatic Fever" @default.
• W2003994310 cites W1512303606 @default.
• W2003994310 cites W1550798157 @default.
• W2003994310 cites W1992901089 @default.
• W2003994310 cites W2008866279 @default.
• W2003994310 cites W2015757689 @default.
• W2003994310 cites W2031581962 @default.
• W2003994310 cites W2055210731 @default.
• W2003994310 cites W2062426795 @default.
• W2003994310 cites W2062842869 @default.
• W2003994310 cites W2066822843 @default.
• W2003994310 cites W2070192407 @default.
• W2003994310 cites W2079016503 @default.
• W2003994310 cites W2084946992 @default.
• W2003994310 cites W2094954825 @default.
• W2003994310 cites W2098794031 @default.
• W2003994310 cites W2123200688 @default.
• W2003994310 cites W2165819997 @default.
• W2003994310 cites W2166534473 @default.
• W2003994310 cites W2170119933 @default.
• W2003994310 cites W2270536249 @default.
• W2003994310 doi "https://doi.org/10.1006/jaut.2000.0487" @default.
• W2003994310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11334505" @default.
• W2003994310 hasPublicationYear "2001" @default.
• W2003994310 type Work @default.
• W2003994310 sameAs 2003994310 @default.
• W2003994310 citedByCount "40" @default.
• W2003994310 countsByYear W20039943102012 @default.
• W2003994310 countsByYear W20039943102013 @default.
• W2003994310 countsByYear W20039943102015 @default.
• W2003994310 countsByYear W20039943102016 @default.
• W2003994310 countsByYear W20039943102018 @default.
• W2003994310 countsByYear W20039943102021 @default.
• W2003994310 countsByYear W20039943102023 @default.
• W2003994310 crossrefType "journal-article" @default.
• W2003994310 hasAuthorship W2003994310A5000888675 @default.
• W2003994310 hasAuthorship W2003994310A5033255349 @default.
• W2003994310 hasAuthorship W2003994310A5038430349 @default.
• W2003994310 hasAuthorship W2003994310A5063842988 @default.
• W2003994310 hasAuthorship W2003994310A5071449715 @default.
• W2003994310 hasAuthorship W2003994310A5087639158 @default.
• W2003994310 hasConcept C142724271 @default.
• W2003994310 hasConcept C147483822 @default.
• W2003994310 hasConcept C159654299 @default.
• W2003994310 hasConcept C17991360 @default.
• W2003994310 hasConcept C203014093 @default.
• W2003994310 hasConcept C2776090121 @default.
• W2003994310 hasConcept C2777119779 @default.
• W2003994310 hasConcept C2778690821 @default.
• W2003994310 hasConcept C2780074459 @default.
• W2003994310 hasConcept C2780130043 @default.
• W2003994310 hasConcept C2780942790 @default.
• W2003994310 hasConcept C2781236483 @default.
• W2003994310 hasConcept C71924100 @default.
• W2003994310 hasConcept C8891405 @default.
• W2003994310 hasConceptScore W2003994310C142724271 @default.
• W2003994310 hasConceptScore W2003994310C147483822 @default.
• W2003994310 hasConceptScore W2003994310C159654299 @default.
• W2003994310 hasConceptScore W2003994310C17991360 @default.
• W2003994310 hasConceptScore W2003994310C203014093 @default.
• W2003994310 hasConceptScore W2003994310C2776090121 @default.
• W2003994310 hasConceptScore W2003994310C2777119779 @default.
• W2003994310 hasConceptScore W2003994310C2778690821 @default.
• W2003994310 hasConceptScore W2003994310C2780074459 @default.
• W2003994310 hasConceptScore W2003994310C2780130043 @default.
• W2003994310 hasConceptScore W2003994310C2780942790 @default.
• W2003994310 hasConceptScore W2003994310C2781236483 @default.
• W2003994310 hasConceptScore W2003994310C71924100 @default.
• W2003994310 hasConceptScore W2003994310C8891405 @default.
• W2003994310 hasIssue "3" @default.
• W2003994310 hasLocation W20039943101 @default.
• W2003994310 hasLocation W20039943102 @default.
• W2003994310 hasOpenAccess W2003994310 @default.
• W2003994310 hasPrimaryLocation W20039943101 @default.
• W2003994310 hasRelatedWork W2032179286 @default.
• W2003994310 hasRelatedWork W2095005655 @default.
• W2003994310 hasRelatedWork W2098138696 @default.
• W2003994310 hasRelatedWork W2119331473 @default.
• W2003994310 hasRelatedWork W2169392074 @default.
• W2003994310 hasRelatedWork W2587791839 @default.
• W2003994310 hasRelatedWork W2966805733 @default.
• W2003994310 hasRelatedWork W4293206736 @default.
• W2003994310 hasRelatedWork W4380324272 @default.
• W2003994310 hasRelatedWork W978077797 @default.
• W2003994310 hasVolume "16" @default.
• W2003994310 isParatext "false" @default.
• W2003994310 isRetracted "false" @default.
• W2003994310 magId "2003994310" @default.

• next