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- W2003996419 abstract "Single-molecule DNA experiments have revealed a number of observations about the mechanical properties of DNA, but little is known about the dynamics of twist and bend in these experiments. To understand these experiments, we develop and solve a stochastic and elastic model for twist dynamics in a DNA molecule that is driven at one end and dissipates torsional energy through viscous drag at the other end. To ensure that torque fluctuations remain finite in our model, we include a term depending on the gradient-squared of twist strain. We find that the boundary conditions of our system quantize the spectrum of DNA twisting modes and modulate the dynamics in a striking way. To see this, we derive a nonequilibrium fluctuation relation for twist and construct the spatiotemporal correlation function. We find that a novel elastic correlation length controls spatial correlations between twist fluctuations. In the middle of a long DNA molecule, twist correlations initially decay as t−1/4 and crossover to t−1/2 decay at longer times. In contrast, in a shorter molecule, correlations decay exponentially with a decay time that depends on the magnitude of the viscous drag. For nearly straight DNA molecules, twist dynamics are unaffected by bending fluctuations at linear order, even though writhing dynamics are modulated by twist at this order. Our model for twist dynamics suggests several new single-molecule experiments, which could shed further light on DNA mechanics and dynamics." @default.
- W2003996419 created "2016-06-24" @default.
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- W2003996419 date "2014-01-01" @default.
- W2003996419 modified "2023-09-26" @default.
- W2003996419 title "Elastic Twist Dynamics of DNA" @default.
- W2003996419 doi "https://doi.org/10.1016/j.bpj.2013.11.1636" @default.
- W2003996419 hasPublicationYear "2014" @default.
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