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• W2004000017 abstract "Cytokines and growth factors have been proposed to act as in vivo modulators of amnion prostaglandin production at parturition. To characterize the effects of the ‘anti-inflammatory’ cytokine interleukin (IL)-4 on amnion prostaglandin production, amnion epithelium-derived WISH cells were treated with IL-4 in the presence/absence of IL-1β, tumour necrosis factor-α (TNF-α) or epidermal growth factor (EGF). IL-4 (0.08–10 ng/ml) potently inhibited cytokine-stimulated PGE2production over 16 h (maximal inhibition 66% at 2.0 ng/ml IL-4). Delaying addition of IL-4 (1 ng/ml) by up to 8 h after IL-1β addition only slightly attenuated its inhibitory effects, from 65% to 50%. EGF-stimulated PGE2production was either not inhibited or slightly stimulated by IL-4. Immunoblotting studies revealed that IL-4 (10 ng/ml) significantly suppressed prostaglandin-H synthase-2 (PGHS-2) levels in cells stimulated with IL-1β and TNF-α over 16 h, but had no consistent effects on cytosolic phospholipase A2(cPLA2) levels under any condition. In the presence of arachidonic acid (10 μM), IL-4 again inhibited cytokine-stimulated, but not EGF-stimulated, PGE2production. The presence of IL-4 also failed to alter the amount of arachidonic acid released in response to EGF. These findings suggest a role and potential therapeutic application for IL-4 in inhibiting amnion PGHS-2 expression and hence prostaglandin production in infection-driven preterm labour, but not labour in the absence of inflammatory initiators." @default.
• W2004000017 created "2016-06-24" @default.
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• W2004000017 date "1999-04-01" @default.
• W2004000017 modified "2023-09-23" @default.
• W2004000017 title "Interleukin-4 differentially regulates prostaglandin production in amnion-derived WISH cells stimulated with pro-inflammatory cytokines and epidermal growth factor" @default.
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• W2004000017 doi "https://doi.org/10.1054/plef.1999.0033" @default.
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