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- W2004000958 abstract "The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid change from IFNgamma production to the immunosuppressive mediator interleukin 10 (IL-10). This mechanism may contribute to the low levels of T cell responses observed to this pathogen in malaria-endemic areas." @default.
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- W2004000958 date "1999-06-01" @default.
- W2004000958 modified "2023-09-26" @default.
- W2004000958 title "Interleukin 10–Mediated Immunosuppression by a Variant CD4 T Cell Epitope of Plasmodium falciparum" @default.
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- W2004000958 doi "https://doi.org/10.1016/s1074-7613(00)80064-3" @default.
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