FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004010919> ?p ?o ?g. }

• W2004010919 endingPage "274" @default.
• W2004010919 startingPage "189" @default.
• W2004010919 abstract "The γ-aminobutyric acid type A (GABAA) receptor represents an elementary switching mechanism integral to the functioning of the central nervous system and a locus for the action of many mood-and emotion-altering agents such as benzodiazepines, barbiturates, steroids, and alcohol. Anxiety, sleep disorders, and convulsive disorders have been effectively treated with therapeutic agents that enhance the action of GABA at the GABAA receptor or increase the concentration of GABA in nervous tissue. The GABAA receptor is a multimeric membrane-spanning ligand-gated ion channel that admits chloride upon binding of the neurotransmitter GABA and is modulated by many endogenous and therapeutically important agents. Since GABA is the major inhibitory neurotransmitter in the CNS, modulation of its response has profound implications for brain functioning. The GABAA receptor is virtually the only site of action for the centrally acting benzodiazepines, the most widely prescribed of the anti-anxiety medications. Increasing evidence points to an important role for GABA in epilepsy and various neuropsychiatric disorders. Recent advances in molecular biology and complementary information derived from pharmacology, biochemistry, electrophysiology, anatomy and cell biology, and behavior have led to a phenomenal growth in our understanding of the structure, function, regulation, and evolution of the GABAA receptor. Benzodiazepines, barbiturates, steroids, polyvalent cations, and ethanol act as positive or negative modulators of receptor function. The description of a receptor gene superfamily comprising the subunits of the GABAA, nicotinic acetylcholine, and glycine receptors has led to a new way of thinking about gene expression and receptor assembly in the nervous system. Seventeen genetically distinct subunit subtypes (αl-α6, βl-β4, γl-γ4,δ, pl-p2) and alternatively spliced variants contribute to the molecular architecture of the GABAA receptor. Mysteriously, certain preferred combinations of subunits, most notably the αlβ2γ2 arrangement, are widely codistributed, while the expression of other subunits, such as βl or α6, is severely restricted to specific neurons in the hippocampal formation or cerebellar cortex. Nervous tissue has the capacity to exert control over receptor number, allosteric uncoupling, subunit mRNA levels, and posttranslational modifications." @default.
• W2004010919 created "2016-06-24" @default.
• W2004010919 creator A5000768396 @default.
• W2004010919 creator A5030434757 @default.
• W2004010919 creator A5072309242 @default.
• W2004010919 date "1995-11-01" @default.
• W2004010919 modified "2023-09-25" @default.
• W2004010919 title "From ion currents to genomic analysis: Recent advances in GABAA receptor research" @default.
• W2004010919 cites W111125735 @default.
• W2004010919 cites W119108515 @default.
• W2004010919 cites W121927115 @default.
• W2004010919 cites W1452571266 @default.
• W2004010919 cites W1490321355 @default.
• W2004010919 cites W1496753504 @default.
• W2004010919 cites W1499258600 @default.
• W2004010919 cites W1500719964 @default.
• W2004010919 cites W1504992746 @default.
• W2004010919 cites W1514573559 @default.
• W2004010919 cites W1524203275 @default.
• W2004010919 cites W1528268403 @default.
• W2004010919 cites W1528288950 @default.
• W2004010919 cites W1528357034 @default.
• W2004010919 cites W1528717760 @default.
• W2004010919 cites W1537557435 @default.
• W2004010919 cites W1544104924 @default.
• W2004010919 cites W1544963 @default.
• W2004010919 cites W1549549440 @default.
• W2004010919 cites W1551449526 @default.
• W2004010919 cites W1551663317 @default.
• W2004010919 cites W1552345748 @default.
• W2004010919 cites W1559776259 @default.
• W2004010919 cites W1563037009 @default.
• W2004010919 cites W1565551672 @default.
• W2004010919 cites W1567146715 @default.
• W2004010919 cites W1570041854 @default.
• W2004010919 cites W1570185216 @default.
• W2004010919 cites W1574744729 @default.
• W2004010919 cites W1575659173 @default.
• W2004010919 cites W158476466 @default.
• W2004010919 cites W1587275242 @default.
• W2004010919 cites W1593349864 @default.
• W2004010919 cites W1595197310 @default.
• W2004010919 cites W1597869519 @default.
• W2004010919 cites W1599442582 @default.
• W2004010919 cites W1606910143 @default.
• W2004010919 cites W1606994795 @default.
• W2004010919 cites W1607645391 @default.
• W2004010919 cites W1608074109 @default.
• W2004010919 cites W1616776977 @default.
• W2004010919 cites W1657090468 @default.
• W2004010919 cites W1676198809 @default.
• W2004010919 cites W1722211492 @default.
• W2004010919 cites W1727542344 @default.
• W2004010919 cites W1756054 @default.
• W2004010919 cites W177013919 @default.
• W2004010919 cites W1779844881 @default.
• W2004010919 cites W1784526106 @default.
• W2004010919 cites W1794897677 @default.
• W2004010919 cites W1798308120 @default.
• W2004010919 cites W1814468920 @default.
• W2004010919 cites W1815276265 @default.
• W2004010919 cites W1828083423 @default.
• W2004010919 cites W1837741502 @default.
• W2004010919 cites W1872667629 @default.
• W2004010919 cites W1877334982 @default.
• W2004010919 cites W1899918478 @default.
• W2004010919 cites W1908131908 @default.
• W2004010919 cites W1944090432 @default.
• W2004010919 cites W1964367807 @default.
• W2004010919 cites W1964459462 @default.
• W2004010919 cites W1964753656 @default.
• W2004010919 cites W1964790247 @default.
• W2004010919 cites W1965198682 @default.
• W2004010919 cites W1965201203 @default.
• W2004010919 cites W1965666249 @default.
• W2004010919 cites W1966087347 @default.
• W2004010919 cites W1966644055 @default.
• W2004010919 cites W1966896681 @default.
• W2004010919 cites W1966947502 @default.
• W2004010919 cites W1968420491 @default.
• W2004010919 cites W1968513558 @default.
• W2004010919 cites W1968531633 @default.
• W2004010919 cites W1968898388 @default.
• W2004010919 cites W1969156296 @default.
• W2004010919 cites W1969298023 @default.
• W2004010919 cites W1969504133 @default.
• W2004010919 cites W1969683921 @default.
• W2004010919 cites W1969880037 @default.
• W2004010919 cites W1970429382 @default.
• W2004010919 cites W1970739803 @default.
• W2004010919 cites W1970990763 @default.
• W2004010919 cites W1971126847 @default.
• W2004010919 cites W1971170321 @default.
• W2004010919 cites W1971273652 @default.
• W2004010919 cites W1972352419 @default.
• W2004010919 cites W1972572613 @default.
• W2004010919 cites W1972823445 @default.
• W2004010919 cites W1972995375 @default.

• next