FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004011941> ?p ?o ?g. }

• W2004011941 endingPage "212" @default.
• W2004011941 startingPage "202" @default.
• W2004011941 abstract "It is well established that reduction of Ca2+ influx through L-type voltage-dependent Ca2+ channel (L-type VDCC), or increase of cytosolic cAMP concentration ([cAMP]c), inhibit contractile activity of smooth muscles in response to transmitters released from sympathetic nerves. Surprisingly, in this work we observed that simultaneous administration of L-type VDCC blocker (verapamil) and [cAMP]c enhancers (rolipram, IBMX and forskolin) potentiated purinergic contractions evoked by electrical field stimulation of rat vas deferens, instead of inhibiting them. These results, including its role in sympathetic transmission, can be considered as a calcium paradox. On the other hand, this potentiation was prevented by reduction of [cAMP]c by inhibition of adenylyl cyclase (SQ 22536) or depletion of Ca2+ storage of sarco-endoplasmic reticulum by blockade of Ca2+ reuptake (thapsigargin). In addition, cytosolic Ca2+ concentration ([Ca2+]c) evaluated by fluorescence microscopy in rat adrenal medullary slices was significantly reduced by verapamil or rolipram. In contrast, simultaneous incubation of adrenal slices with these compounds significantly increased [Ca2+]c. This effect was prevented by thapsigargin. Thus, a reduction of [Ca2+]c due to blockade of Ca2+ influx through L-type VDCC could stimulate adenylyl cyclase activity increasing [cAMP]c thereby stimulating Ca2+ release from endoplasmic reticulum, resulting in augmented transmitter release in sympathetic nerves and contraction." @default.
• W2004011941 created "2016-06-24" @default.
• W2004011941 creator A5001154643 @default.
• W2004011941 creator A5001723284 @default.
• W2004011941 creator A5001930137 @default.
• W2004011941 creator A5029269835 @default.
• W2004011941 creator A5044267709 @default.
• W2004011941 creator A5047973201 @default.
• W2004011941 creator A5056013254 @default.
• W2004011941 date "2013-09-01" @default.
• W2004011941 modified "2023-10-02" @default.
• W2004011941 title "Novel model for “calcium paradox” in sympathetic transmission of smooth muscles: Role of cyclic AMP pathway" @default.
• W2004011941 cites W1963823473 @default.
• W2004011941 cites W1967178738 @default.
• W2004011941 cites W1969837407 @default.
• W2004011941 cites W1973966511 @default.
• W2004011941 cites W1990499518 @default.
• W2004011941 cites W1995179004 @default.
• W2004011941 cites W1997285223 @default.
• W2004011941 cites W2006442989 @default.
• W2004011941 cites W2010888041 @default.
• W2004011941 cites W2025480110 @default.
• W2004011941 cites W2028205689 @default.
• W2004011941 cites W2032237431 @default.
• W2004011941 cites W2032860166 @default.
• W2004011941 cites W2034120137 @default.
• W2004011941 cites W2037815069 @default.
• W2004011941 cites W2039932609 @default.
• W2004011941 cites W2040410541 @default.
• W2004011941 cites W2046491231 @default.
• W2004011941 cites W2047663792 @default.
• W2004011941 cites W2068986363 @default.
• W2004011941 cites W2076668779 @default.
• W2004011941 cites W2077304039 @default.
• W2004011941 cites W2082972941 @default.
• W2004011941 cites W2084301593 @default.
• W2004011941 cites W2085729934 @default.
• W2004011941 cites W2088795713 @default.
• W2004011941 cites W2105951582 @default.
• W2004011941 cites W2112520390 @default.
• W2004011941 cites W2117408254 @default.
• W2004011941 cites W2117800607 @default.
• W2004011941 cites W2127496841 @default.
• W2004011941 cites W2133453220 @default.
• W2004011941 cites W2137229430 @default.
• W2004011941 cites W2141260882 @default.
• W2004011941 cites W2151099056 @default.
• W2004011941 cites W3024219013 @default.
• W2004011941 cites W3026759874 @default.
• W2004011941 doi "https://doi.org/10.1016/j.ceca.2013.06.004" @default.
• W2004011941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23849429" @default.
• W2004011941 hasPublicationYear "2013" @default.
• W2004011941 type Work @default.
• W2004011941 sameAs 2004011941 @default.
• W2004011941 citedByCount "33" @default.
• W2004011941 countsByYear W20040119412014 @default.
• W2004011941 countsByYear W20040119412015 @default.
• W2004011941 countsByYear W20040119412016 @default.
• W2004011941 countsByYear W20040119412017 @default.
• W2004011941 countsByYear W20040119412018 @default.
• W2004011941 countsByYear W20040119412019 @default.
• W2004011941 countsByYear W20040119412020 @default.
• W2004011941 countsByYear W20040119412021 @default.
• W2004011941 countsByYear W20040119412022 @default.
• W2004011941 crossrefType "journal-article" @default.
• W2004011941 hasAuthorship W2004011941A5001154643 @default.
• W2004011941 hasAuthorship W2004011941A5001723284 @default.
• W2004011941 hasAuthorship W2004011941A5001930137 @default.
• W2004011941 hasAuthorship W2004011941A5029269835 @default.
• W2004011941 hasAuthorship W2004011941A5044267709 @default.
• W2004011941 hasAuthorship W2004011941A5047973201 @default.
• W2004011941 hasAuthorship W2004011941A5056013254 @default.
• W2004011941 hasConcept C126322002 @default.
• W2004011941 hasConcept C134018914 @default.
• W2004011941 hasConcept C158617107 @default.
• W2004011941 hasConcept C185592680 @default.
• W2004011941 hasConcept C24998067 @default.
• W2004011941 hasConcept C2776766087 @default.
• W2004011941 hasConcept C2777022698 @default.
• W2004011941 hasConcept C2777146706 @default.
• W2004011941 hasConcept C2779178603 @default.
• W2004011941 hasConcept C2779276759 @default.
• W2004011941 hasConcept C519063684 @default.
• W2004011941 hasConcept C55493867 @default.
• W2004011941 hasConcept C71924100 @default.
• W2004011941 hasConcept C86803240 @default.
• W2004011941 hasConceptScore W2004011941C126322002 @default.
• W2004011941 hasConceptScore W2004011941C134018914 @default.
• W2004011941 hasConceptScore W2004011941C158617107 @default.
• W2004011941 hasConceptScore W2004011941C185592680 @default.
• W2004011941 hasConceptScore W2004011941C24998067 @default.
• W2004011941 hasConceptScore W2004011941C2776766087 @default.
• W2004011941 hasConceptScore W2004011941C2777022698 @default.
• W2004011941 hasConceptScore W2004011941C2777146706 @default.
• W2004011941 hasConceptScore W2004011941C2779178603 @default.
• W2004011941 hasConceptScore W2004011941C2779276759 @default.
• W2004011941 hasConceptScore W2004011941C519063684 @default.
• W2004011941 hasConceptScore W2004011941C55493867 @default.

• next