FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004013202> ?p ?o ?g. }

• W2004013202 endingPage "358" @default.
• W2004013202 startingPage "351" @default.
• W2004013202 abstract "Growing evidence suggests an involvement of brain membrane phospholipid metabolism in a variety of neurodegenerative and psychiatric conditions. This has prompted the use of drugs (e.g., CDPcholine) aimed at elevating the rate of neural membrane synthesis. However, no information is available regarding the human brain enzymes of phospholipid synthesis which these drugs affect. Thus, the objective of our study was to characterize the enzymes involved, in particular, whether differences existed in the relative affinity of substrates for the enzymes of phosphatidylethanolamine (PE) compared to those of phosphatidylcholine (PC) synthesis. The concentration of choline in rapidly frozen human brain biopsies ranged from 32-186 nmol/g tissue, a concentration similar to that determined previously for ethanolamine. Since human brain ethanolamine kinase possessed a much lower affinity for ethanolamine (Km = 460 microM) than choline kinase did for choline (Km = 17 microM), the activity of ethanolamine kinase in vivo may be more dependent on substrate availability than that of choline kinase. In addition, whereas ethanolamine kinase was inhibited by choline, and to a lesser extent by phosphocholine, choline kinase activity was unaffected by the presence of ethanolamine, or phosphoethanolamine, and only weakly inhibited by phosphocholine. Phosphoethanolamine cytidylyltransferase (PECT) and phosphocholine cytidylyltransferase (PCCT) also displayed dissimilar characteristics, with PECT and PCCT being located predominantly in the cytosolic and particulate fractions, respectively. Both PECT and PCCT exhibited a low affinity for CTP (Km approximately 1.2 mM), suggesting that the activities of these enzymes, and by implication, the rate of phospholipid synthesis, are highly dependent upon the cellular concentration of CTP. In conclusion our data indicate different regulatory properties of PE and PC synthesis in human brain, and suggest that the rate of PE synthesis may be more dependent upon substrate (ethanolamine) availability than that of PC synthesis." @default.
• W2004013202 created "2016-06-24" @default.
• W2004013202 creator A5000210550 @default.
• W2004013202 creator A5021103203 @default.
• W2004013202 creator A5043499047 @default.
• W2004013202 creator A5071124477 @default.
• W2004013202 creator A5086674512 @default.
• W2004013202 creator A5091533768 @default.
• W2004013202 date "1997-04-01" @default.
• W2004013202 modified "2023-09-27" @default.
• W2004013202 title "Phospholipid biosynthetic enzymes in human brain" @default.
• W2004013202 cites W130914049 @default.
• W2004013202 cites W1539431389 @default.
• W2004013202 cites W1565344536 @default.
• W2004013202 cites W1596003471 @default.
• W2004013202 cites W1895560631 @default.
• W2004013202 cites W1965452878 @default.
• W2004013202 cites W1970536605 @default.
• W2004013202 cites W1980606866 @default.
• W2004013202 cites W1982415357 @default.
• W2004013202 cites W1994370147 @default.
• W2004013202 cites W1994801999 @default.
• W2004013202 cites W1995954863 @default.
• W2004013202 cites W1998738075 @default.
• W2004013202 cites W2010316443 @default.
• W2004013202 cites W2025488960 @default.
• W2004013202 cites W2032054466 @default.
• W2004013202 cites W2038113019 @default.
• W2004013202 cites W2043988433 @default.
• W2004013202 cites W2048530944 @default.
• W2004013202 cites W2052857020 @default.
• W2004013202 cites W2053254124 @default.
• W2004013202 cites W2053490836 @default.
• W2004013202 cites W2056246499 @default.
• W2004013202 cites W2057515919 @default.
• W2004013202 cites W2065892543 @default.
• W2004013202 cites W2070804893 @default.
• W2004013202 cites W2084676131 @default.
• W2004013202 cites W2084810576 @default.
• W2004013202 cites W2085007671 @default.
• W2004013202 cites W2086891165 @default.
• W2004013202 cites W2088428258 @default.
• W2004013202 cites W2089307642 @default.
• W2004013202 cites W2094264684 @default.
• W2004013202 cites W2095341695 @default.
• W2004013202 cites W2101077067 @default.
• W2004013202 cites W2143127986 @default.
• W2004013202 cites W2145992999 @default.
• W2004013202 cites W2148512456 @default.
• W2004013202 cites W2166835169 @default.
• W2004013202 cites W2168526937 @default.
• W2004013202 cites W2170113921 @default.
• W2004013202 cites W4211252642 @default.
• W2004013202 cites W942881620 @default.
• W2004013202 doi "https://doi.org/10.1007/s11745-997-0044-x" @default.
• W2004013202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9113621" @default.
• W2004013202 hasPublicationYear "1997" @default.
• W2004013202 type Work @default.
• W2004013202 sameAs 2004013202 @default.
• W2004013202 citedByCount "62" @default.
• W2004013202 countsByYear W20040132022012 @default.
• W2004013202 countsByYear W20040132022013 @default.
• W2004013202 countsByYear W20040132022014 @default.
• W2004013202 countsByYear W20040132022015 @default.
• W2004013202 countsByYear W20040132022016 @default.
• W2004013202 countsByYear W20040132022017 @default.
• W2004013202 countsByYear W20040132022018 @default.
• W2004013202 countsByYear W20040132022019 @default.
• W2004013202 countsByYear W20040132022020 @default.
• W2004013202 countsByYear W20040132022021 @default.
• W2004013202 countsByYear W20040132022022 @default.
• W2004013202 crossrefType "journal-article" @default.
• W2004013202 hasAuthorship W2004013202A5000210550 @default.
• W2004013202 hasAuthorship W2004013202A5021103203 @default.
• W2004013202 hasAuthorship W2004013202A5043499047 @default.
• W2004013202 hasAuthorship W2004013202A5071124477 @default.
• W2004013202 hasAuthorship W2004013202A5086674512 @default.
• W2004013202 hasAuthorship W2004013202A5091533768 @default.
• W2004013202 hasConcept C181199279 @default.
• W2004013202 hasConcept C184235292 @default.
• W2004013202 hasConcept C185592680 @default.
• W2004013202 hasConcept C2776330855 @default.
• W2004013202 hasConcept C2776923060 @default.
• W2004013202 hasConcept C2778918659 @default.
• W2004013202 hasConcept C2779216040 @default.
• W2004013202 hasConcept C2780601828 @default.
• W2004013202 hasConcept C2781123555 @default.
• W2004013202 hasConcept C2781170229 @default.
• W2004013202 hasConcept C41625074 @default.
• W2004013202 hasConcept C55493867 @default.
• W2004013202 hasConcept C86803240 @default.
• W2004013202 hasConceptScore W2004013202C181199279 @default.
• W2004013202 hasConceptScore W2004013202C184235292 @default.
• W2004013202 hasConceptScore W2004013202C185592680 @default.
• W2004013202 hasConceptScore W2004013202C2776330855 @default.
• W2004013202 hasConceptScore W2004013202C2776923060 @default.
• W2004013202 hasConceptScore W2004013202C2778918659 @default.
• W2004013202 hasConceptScore W2004013202C2779216040 @default.

• next