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- W2004013641 abstract "Interferon-α (IFN-α) is used for the treatment of Chronic Hepatitis C Viral infection, however it causes as side effect the development of depression in about the 30–40% of patients. Here we aimed at identify putative biological processes underlying depression development. We recruited 54 HCV patients undertaking IFN-α treatment. Blood was collected using PAXgene Blood RNA Tubes at baseline, TW4, 12 and 24 and depression was diagnosed using the M.I.N.I. We conducted microarray gene expression analyses in the blood of patients at week 0, 4 and 12/24. Statistical analyses, to identify genes and pathways differentially modulated by IFN-α treatment and in relation to depression development, were conducted by Partek Genomic Suite and Ariadne Pathway Software. Atotal number of 754 genes was modulated in the whole sample of patients (p < 0.001, 1.4 < FC < −1.4). Further analyses were performed by comparing the transcriptomic profile of patients that developed depression versus patients that did not develop depression, at treatment week 4 versus baseline, in order to identify genes and pathways modulated by IFN-α in relation with depression development. We found that, at week 4, 489 genes were modulated by IFN-α only in patients that developed depression, 57 genes were modulated by IFN-α only in patients without IFN-α-induced depression and 258 genes were in common between the two groups of patients. A pathway analyses revealed a down-regulation of the notch and neurotrophin signaling, and an up-regulation of natural killer cells mediated cell cytotoxicity and toll like receptor pathways. This study suggests that patients developing IFN-α induced depression have an immune system more reactive to the effect of the treatment and support the involvement of neuroplastic and inflammatory system as processes underlying depression development." @default.
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- W2004013641 date "2014-09-01" @default.
- W2004013641 modified "2023-09-27" @default.
- W2004013641 title "11. Transcriptomic analyses in the blood of HCV infected patients during IFN-a therapy: Identification of mechanisms underlying depression development" @default.
- W2004013641 doi "https://doi.org/10.1016/j.bbi.2014.06.031" @default.
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